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11,12-De(methylenedioxy)danuphylline
11,12-De(methylenedioxy)danuphylline
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 11,12-De(methylenedioxy)danuphylline
Price:
CAS No.: 888482-17-5
Catalog No.: CFN97456
Molecular Formula: C23H26N2O6
Molecular Weight: 426.5 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Cryst.
Source: The branches of Kopsia officinalis
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Standard reference
In vitro:
Helvetica Chimica Acta.2006 March;89(3):515–519.
Three New Indole Alkaloids from the Leaves of Kopsia officinalis.[Reference: WebLink]

METHODS AND RESULTS:
Three new indole alkaloids, 11,12-De(methylenedioxy)danuphylline (1), methyl (2β,11β,12β,19α)-6,7-didehydro-8,21-dioxo-11,21-cycloaspidospermidine-2-carboxylate (2), and (2β,5β)-aspidofractinin-16-ol (3) were isolated from Kopsia officinalis, together with 16 known compounds. Their structures were determined by spectroscopic methods.
CONCLUSIONS:
The isolated known compound (−)-12-methoxykopsinaline displayed antimanic effects in Drosophila, with an IC50 value of 12.5 μg/ml.
11,12-De(methylenedioxy)danuphylline Description
Source: The branches of Kopsia officinalis
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.3447 mL 11.7233 mL 23.4467 mL 46.8933 mL 58.6166 mL
5 mM 0.4689 mL 2.3447 mL 4.6893 mL 9.3787 mL 11.7233 mL
10 mM 0.2345 mL 1.1723 mL 2.3447 mL 4.6893 mL 5.8617 mL
50 mM 0.0469 mL 0.2345 mL 0.4689 mL 0.9379 mL 1.1723 mL
100 mM 0.0234 mL 0.1172 mL 0.2345 mL 0.4689 mL 0.5862 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
CFN96068Conopharyngine76-98-2398.5C23H30N2O4
CFN9606919(S)-Hydroxyconopharyngine16790-93-5414.5C23H30N2O5
CFN96176Crassanine16790-92-4414.5C23H30N2O5
CFN99765Catharanthine2468-21-5336.43C21H24N2O2
CFN90318Catharanthine Tartrate2648-21-5486.40C21H24N2O2.C4H6O6
CFN93298Catharanthine Sulfate70674-90-7434.51C21H26N2O6S
CFN9843219,20-(E)-Vallesamine3368-87-4340.4 C20H24N2O3
CFN99377Vallesamine N-oxide126594-73-8356.4 C20H24N2O4
CFN97275Methyl demethoxycarbonylchanofruticosinate80151-89-9352.4 C21H24N2O3
CFN9745611,12-De(methylenedioxy)danuphylline888482-17-5426.5 C23H26N2O6
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