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11,15-Dihydroxy-16-kauren-19-oic acid
11,15-Dihydroxy-16-kauren-19-oic acid
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 11,15-Dihydroxy-16-kauren-19-oic acid
Price:
CAS No.: 57719-76-3
Catalog No.: CFN98977
Molecular Formula: C20H30O4
Molecular Weight: 334.5 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Source: The herbs of Cerbera manghas
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
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Biological Activity
Description: Reference standards.
In vitro:
CHEMICAL & PHARMACEUTICAL BULLETIN, 1990, 38(5):1308-1312.
Kaurane-type diterpenes from Adenostemma lavenia O. Kuntze.[Reference: WebLink]

METHODS AND RESULTS:
Ten 11-oxygenated kauran-19-oic acids, ent-11α, 15α-dihydroxykaur-16-en-19-oic acid(11,15-Dihydroxy-16-kauren-19-oic acid), ent-11α-hydroxy-15α-acetoxykaur-16-en-19-oic acid, ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic acid and adenostemmoic acids A-G and their nine glycosides, paniculosides II and III and adenostemmosides A-G were characterized from Adenostemma lavenia O. KUNTZE. ent-11α-Hydroxy-15-oxo-kaur-16-en-19-oic acid and adenostemmoic acid B showed cytotoxic activity against L-5178Y cultured cell and prolonged the survival of mice.
11,15-Dihydroxy-16-kauren-19-oic acid Description
Source: The herbs of Cerbera manghas
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

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Sci Adv. 2018 Oct 24;4(10): eaat6994.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9895 mL 14.9477 mL 29.8954 mL 59.7907 mL 74.7384 mL
5 mM 0.5979 mL 2.9895 mL 5.9791 mL 11.9581 mL 14.9477 mL
10 mM 0.299 mL 1.4948 mL 2.9895 mL 5.9791 mL 7.4738 mL
50 mM 0.0598 mL 0.299 mL 0.5979 mL 1.1958 mL 1.4948 mL
100 mM 0.0299 mL 0.1495 mL 0.299 mL 0.5979 mL 0.7474 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Journal of Natural Products, 1979, 42(2):183-186.
Isolation of 11-Hydroxyated Kauranic Acids From Adenostemma lavenia.[Reference: WebLink]

METHODS AND RESULTS:
Four 11-hydroxylated kauranic acids were characterized from Adenostemma lavenia (L.) O. Kuntze, namely: ent-11α-hydroxy-15α-acetoxykaur-16-en-19-oic acid (1), ent-11α, 15α-dihydroxykaur-16-en-19-oic acid (11,15-Dihydroxy-16-kauren-19-oic acid ,2), (16R)-ent-11α-hydroxy-15-oxokauran-19-oic acid (3), and ent-11α-hydroxy-15-oxokaur-16-en-19-oic acid (4).
CFN97975Pterisolic acid A1401419-85-9346.4C20H26O5
CFN97976Pterisolic acid B1401419-86-0330.4C20H26O4
CFN89078ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid57719-81-0332.44C20H28O4
CFN89216Paniculoside III60129-65-9494.58C26H38O9
CFN96331ent-16-Kaurene-3beta,15beta,18-triol921211-29-2320.5C20H32O3
CFN97780Grandifloric acid22338-69-8318.46C20H30O3
CFN97131Deacetylxylopic acid6619-95-0318.5 C20H30O3
CFN9897711,15-Dihydroxy-16-kauren-19-oic acid57719-76-3334.5 C20H30O4
CFN97261ent-9-Hydroxy-15-oxo-16-kauren-19-oic acid77658-39-0332.4 C20H28O4
CFN97294ent-6,9-Dihydroxy-15-oxo-16-kauren-19-oic acid81264-00-8348.4 C20H28O5
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