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11,15-Dihydroxy-16-kauren-19-oic acid
11,15-Dihydroxy-16-kauren-19-oic acid
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 11,15-Dihydroxy-16-kauren-19-oic acid
Price:
CAS No.: 57719-76-3
Catalog No.: CFN98977
Molecular Formula: C20H30O4
Molecular Weight: 334.5 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Source: The herbs of Cerbera manghas
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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Biological Activity
Description: Reference standards.
In vitro:
CHEMICAL & PHARMACEUTICAL BULLETIN, 1990, 38(5):1308-1312.
Kaurane-type diterpenes from Adenostemma lavenia O. Kuntze.[Reference: WebLink]

METHODS AND RESULTS:
Ten 11-oxygenated kauran-19-oic acids, ent-11α, 15α-dihydroxykaur-16-en-19-oic acid(11,15-Dihydroxy-16-kauren-19-oic acid), ent-11α-hydroxy-15α-acetoxykaur-16-en-19-oic acid, ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic acid and adenostemmoic acids A-G and their nine glycosides, paniculosides II and III and adenostemmosides A-G were characterized from Adenostemma lavenia O. KUNTZE. ent-11α-Hydroxy-15-oxo-kaur-16-en-19-oic acid and adenostemmoic acid B showed cytotoxic activity against L-5178Y cultured cell and prolonged the survival of mice.
11,15-Dihydroxy-16-kauren-19-oic acid Description
Source: The herbs of Cerbera manghas
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
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IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
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doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

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Nature Plants. 2016 Dec 22;3: 16206.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9895 mL 14.9477 mL 29.8954 mL 59.7907 mL 74.7384 mL
5 mM 0.5979 mL 2.9895 mL 5.9791 mL 11.9581 mL 14.9477 mL
10 mM 0.299 mL 1.4948 mL 2.9895 mL 5.9791 mL 7.4738 mL
50 mM 0.0598 mL 0.299 mL 0.5979 mL 1.1958 mL 1.4948 mL
100 mM 0.0299 mL 0.1495 mL 0.299 mL 0.5979 mL 0.7474 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Journal of Natural Products, 1979, 42(2):183-186.
Isolation of 11-Hydroxyated Kauranic Acids From Adenostemma lavenia.[Reference: WebLink]

METHODS AND RESULTS:
Four 11-hydroxylated kauranic acids were characterized from Adenostemma lavenia (L.) O. Kuntze, namely: ent-11α-hydroxy-15α-acetoxykaur-16-en-19-oic acid (1), ent-11α, 15α-dihydroxykaur-16-en-19-oic acid (11,15-Dihydroxy-16-kauren-19-oic acid ,2), (16R)-ent-11α-hydroxy-15-oxokauran-19-oic acid (3), and ent-11α-hydroxy-15-oxokaur-16-en-19-oic acid (4).
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