12-Oxocalanolide A | CAS:161753-49-7 | Manufacturer ChemFaces

12-Oxocalanolide A

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Description:

12-Oxocalanolide A is an inhibitor of HIV-1 reverse transcriptase (RT) and exhibits activity against a variety of viruse selected for resistance to other HIV-1 nonnucleoside RT inhibitors.

Targets:

HIV

In vitro:

Bioorg Med Chem Lett. 1998 Aug 18;8(16):2179-84

In vitro anti-human immunodeficiency virus (HIV) activity of the chromanone derivative, 12-oxocalanolide A, a novel NNRTI.[Pubmed: 9873509]

METHODS AND RESULTS:
The three chromanone derivatives, (+)-, (-)-, and (+/-)-12-Oxocalanolide A (2), were evaluated for in vitro antiviral activities against HIV and simian immunodeficiency virus (SIV).
CONCLUSIONS:
The compounds were determined to be inhibitors of HIV-1 reverse transcriptase (RT) and exhibited activity against a variety of viruses selected for resistance to other HIV-1 nonnucleoside RT inhibitors. They are the first reported calanolide analogues capable of inhibiting SIV.

In vivo:

J Chromatogr B Biomed Sci Appl. 2000 Jun 9;742(2):267-75.

Quantification of (+)-calanolide A, a novel and naturally occurring anti-HIV agent, by high-performance liquid chromatography in plasma from rat, dog and human.[Pubmed: 10901131]

METHODS AND RESULTS:
A HPLC method was validated for quantification of (+)-calanolide A (1), a novel anti-HIV agent, in rat, dog and human plasma. The synthetic intermediate (+/-)-12-Oxocalanolide A (2) was found to be a suitable internal standard. Compounds were extracted from plasma using a solid-phase C(18) cartridge and quantified over the assay range of 12.5 to 800 ng/ml. The method was utilized to determine (+)-calanolide A pharmacokinetics in rats, dogs and humans. This is the first report of a validated HPLC assay for determination of (+)-calanolide A concentrations in rat and dog plasma as well as human plasma obtained from clinical trials.
CONCLUSIONS:
There was no evidence of in vivo epimerization of (+)-calanolide A to its inactive epimer (+)-calanolide B (3).

12-Oxocalanolide A Description

Source:	The herbs of Calophyllum polyanthum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	12-Oxocalanolide A
Price:
CAS No.:	161753-49-7
Catalog No.:	CFN97812
Molecular Formula:	C₂₂H₂₄O₅
Molecular Weight:	368.43 g/mol
Purity:	>=98%
Type of Compound:	Coumarins
Physical Desc.:	Yellow powder
Source:	The herbs of Calophyllum polyanthum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Antiviral Compound Library Coumarins Compound Library HIV Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.7142 mL	13.5711 mL	27.1422 mL	54.2844 mL	67.8555 mL
5 mM	0.5428 mL	2.7142 mL	5.4284 mL	10.8569 mL	13.5711 mL
10 mM	0.2714 mL	1.3571 mL	2.7142 mL	5.4284 mL	6.7855 mL
50 mM	0.0543 mL	0.2714 mL	0.5428 mL	1.0857 mL	1.3571 mL
100 mM	0.0271 mL	0.1357 mL	0.2714 mL	0.5428 mL	0.6786 mL

CFN97429	7-Hydroxy-3-prenylcoumarin	86654-26-4	230.3	C₁₄H₁₄O₃
CFN98374	7-Hydroxy-6-methoxy-3-prenylcoumarin	299159-90-3	260.3	C₁₅H₁₆O₄
CFN89287	3-(1,1-Dimethylallyl)-8-hydroxy-7-methoxycoumarin	61899-42-1	260.28	C₁₅H₁₆O₄
CFN89033	Chalepensin	13164-03-9	254.28	C₁₆H₁₄O₃
CFN89223	Rutamarin	14882-94-1	356.41	C₂₁H₂₄O₅
CFN89021	Evodosin A	1291053-38-7	280.27	C₁₄H₁₆O₆
CFN97812	12-Oxocalanolide A	161753-49-7	368.43	C₂₂H₂₄O₅
CFN99466	Calanolide E	142566-61-8	388.5	C₂₂H₂₈O₆
CFN90420	7-Amino-4-methylcoumarin	106562-32-7	233.22	C₁₂H₁₁NO₄