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16-Epivoacarpine
16-Epivoacarpine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 16-Epivoacarpine
Price: $318 / 5mg
CAS No.: 114027-38-2
Catalog No.: CFN96030
Molecular Formula: C21H24N2O4
Molecular Weight: 368.4 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The herbs of Gelsemium elegans
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
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Biological Activity
Description: 16-Epivoacarpine is a natural product from Gelsemium elegans.
16-Epivoacarpine Description
Source: The herbs of Gelsemium elegans
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.7144 mL 13.5722 mL 27.1444 mL 54.2888 mL 67.861 mL
5 mM 0.5429 mL 2.7144 mL 5.4289 mL 10.8578 mL 13.5722 mL
10 mM 0.2714 mL 1.3572 mL 2.7144 mL 5.4289 mL 6.7861 mL
50 mM 0.0543 mL 0.2714 mL 0.5429 mL 1.0858 mL 1.3572 mL
100 mM 0.0271 mL 0.1357 mL 0.2714 mL 0.5429 mL 0.6786 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Studies in Natural Products Chemistry, 1995 , 15 (06) :465-518.
Recent advances in the chemistry of Gelsemium alkaloids.[Reference: WebLink]
This chapter reviews the recent intensive research that led to significant progress in the field of Gelsemium alkaloid chemistry. It presents alkaloids isolated from the Gelsemium species.
METHODS AND RESULTS:
The structure elucidation of the representative alkaloids using mainly spectroscopic methods is described. The chapter discusses the biogenetic speculation of the structurally unique Gelsemium alkaloids and the biomimetic transformation of the known indole alkaloids leading to the various skeletal types of Gelsemium alkaloids. A genuine indole nucleus is present only in the sarpagine group and sempervirine among the many skeletal classes of the Gelsemium alkaloids. The sarpagine group found in the Gelsemium species consists of six indole alkaloids, 19( Z )-akuammidine (koumicine), koumicine N -oxide, koumidine, 16-Epivoacarpine, 19(Z)-anhydrovobasine-diol, and N a -methoxy-19( Z )-anhydrovobasinediol.
CONCLUSIONS:
The structure elucidation of the indole alkaloid, the so-called akuammidine isolated from Gelsemium elegans is discussed in the chapter. The configuration of the ethylidene side chain was considered the 19( E ) form as generally found in the monoterpenoid indole alkaloids. The so-called akuammidine from G. elegans showed the same mass spectral fragment pattern as authentic akuammidine obtained from other plant sources.
CFN9603016-Epivoacarpine114027-38-2368.4C21H24N2O4
CFN96018Gelsempervine A865187-17-3382.5C22H26N2O4
CFN9613016-Epinormacusine B126640-98-0294.4C19H22N2O
CFN96747Rauvotetraphylline A1422506-49-7342.43C20H26N2O3
CFN96696Rauvoyunine A1414883-81-0356.46C21H28N2O3
CFN96067Pericyclivine975-77-9322.4C20H22N2O2
CFN90441Perivine2673-40-7338.4C20H22N2O3
CFN96242Akuammidine639-36-1352.4C21H24N2O3
CFN89174Conodurine2665-57-8704.91C43H52N4O5
CFN96750Rauvotetraphylline C1422506-51-1510.58C28H34N2O7
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