2,3-Dihydro-3-methoxywithaferin A | CAS:21902-96-5

2,3-Dihydro-3-methoxywithaferin A

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Description:

2,3-Dihydro-3-methoxywithaferin A is a natural withanolide , is cytotoxic to human cancer cells, and is a candidate anticancer natural compound. It protects normal cells against stress.

Targets:

Akt | MAPK

In vitro:

J Nat Prod. 2017 Oct 27;80(10):2756-2760.

2,3-Dihydro-3β-methoxy Withaferin-A Protects Normal Cells against Stress: Molecular Evidence of Its Potent Cytoprotective Activity.[Pubmed: 29043807]

2,3-Dihydro-3β-methoxy withaferin-A (2,3-Dihydro-3-methoxywithaferin A,3βmWi-A) is a natural withanolide that is structurally close to withaferin-A (Wi-A), is cytotoxic to human cancer cells, and is a candidate anticancer natural compound.
METHODS AND RESULTS:
Using cell-based biochemical, molecular, and imaging assays, we report that Wi-A and 3βmWi-A possess contrasting activities. Whereas Wi-A caused oxidative stress to normal cells, 3βmWi-A was well tolerated at even 10-fold higher concentrations. Furthermore, it promoted survival and protected normal cells against oxidative, UV radiation, and chemical stresses. We provide molecular evidence that 3βmWi-A induces antistress and pro-survival signaling through activation of the pAkt/MAPK pathway.
CONCLUSIONS:
We demonstrate that 3βmWi-A (i) contrary to Wi-A is safe and possesses stress-relieving activity, (ii) when given subsequent to a variety of stress factors including Wi-A, protects normal cells against their toxicity, and (iii) is a vital compound that may guard normal cells against the toxicity associated with various targeted therapeutic regimes in clinical practice.

2,3-Dihydro-3-methoxywithaferin A Description

Source:	The herbs of Physali alkekengi.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	2,3-Dihydro-3-methoxywithaferin A
Price:
CAS No.:	21902-96-5
Catalog No.:	CFN92965
Molecular Formula:	C₂₉H₄₂O₇
Molecular Weight:	502.64 g/mol
Purity:	>=98%
Type of Compound:	Steroids
Physical Desc.:	Powder
Source:	The herbs of Physali alkekengi.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Steroids Compound Library MAPK Inhibitor Library Akt Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.9895 mL	9.9475 mL	19.895 mL	39.7899 mL	49.7374 mL
5 mM	0.3979 mL	1.9895 mL	3.979 mL	7.958 mL	9.9475 mL
10 mM	0.1989 mL	0.9947 mL	1.9895 mL	3.979 mL	4.9737 mL
50 mM	0.0398 mL	0.1989 mL	0.3979 mL	0.7958 mL	0.9947 mL
100 mM	0.0199 mL	0.0995 mL	0.1989 mL	0.3979 mL	0.4974 mL

CFN99414	Daturataturin A	133360-51-7	616.8	C₃₄H₄₈O₁₀
CFN96433	Withaperuvin C	81644-34-0	486.59	C₂₈H₃₈O₇
CFN89294	Physapruin A	155178-03-3	486.60	C₂₈H₃₈O₇
CFN92969	Jaborosalactone D	19891-82-8	472.61	C₂₈H₄₀O₆
CFN91895	Withaferin A	5119-48-2	470.60	C₂₈H₃₈O₆
CFN91055	Dihydrowithaferin A	5589-41-3	472.6	C₂₈H₄₀O₆
CFN96434	Withanolide S	63139-16-2	504.61	C₂₈H₄₀O₈
CFN96435	Withanolide C	108030-78-0	523.05	C₂₈H₃₉ClO₇
CFN91964	Withanolide A	32911-62-9	470.60	C₂₈H₃₈O₆
CFN91967	6alpha-Chloro-5beta-hydroxywithaferin A	52329-20-1	507.06	C₂₈H₃₉ClO₆