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2-Hydroxy-3-(hydroxymethyl)anthraquinone
2-Hydroxy-3-(hydroxymethyl)anthraquinone
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 2-Hydroxy-3-(hydroxymethyl)anthraquinone
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CAS No.: 68243-30-1
Catalog No.: CFN92112
Molecular Formula: C15H10O4
Molecular Weight: 254.2 g/mol
Purity: >=98%
Type of Compound: Anthraquinones
Physical Desc.: Yellow cryst.
Source: The roots of Morinda citrifolia.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
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Biological Activity
Description: 2-Hydroxy-3-(hydroxymethyl)anthraquinone exhibits quinone reductase (QR)- inducing activity in Hepa lclc7 cells, with the concentration required to double QR activity of 0.94 microM.
2-Hydroxy-3-(hydroxymethyl)anthraquinone Description
Source: The roots of Morinda citrifolia.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.9339 mL 19.6696 mL 39.3391 mL 78.6782 mL 98.3478 mL
5 mM 0.7868 mL 3.9339 mL 7.8678 mL 15.7356 mL 19.6696 mL
10 mM 0.3934 mL 1.967 mL 3.9339 mL 7.8678 mL 9.8348 mL
50 mM 0.0787 mL 0.3934 mL 0.7868 mL 1.5736 mL 1.967 mL
100 mM 0.0393 mL 0.1967 mL 0.3934 mL 0.7868 mL 0.9835 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
J Nat Prod. 2007 Dec;70(12):2049-52.
Anthraquinones with quinone reductase-inducing activity and benzophenones from Morinda citrifolia (noni) roots.[Pubmed: 18076142 ]

METHODS AND RESULTS:
Two new benzophenones, morintrifolins A ( 1) and B ( 2), together with 14 known anthraquinones and four other known compounds, were isolated from a chloroform-soluble extract of Morinda citrifolia roots.
CONCLUSIONS:
Of the isolated compounds, four known anthraquinones, namely, 1,2-dihydroxyanthraquinone ( 3), 1,3-dihydroxy-2-methylanthraquinone ( 4), 2-Hydroxy-3-(hydroxymethyl)anthraquinone ( 5), and 1,3,6-trihydroxy-2-methylanthraquinone ( 6), exhibited quinone reductase (QR)- inducing activity in Hepa lclc7 cells, with concentrations required to double QR activity of 12.0, 8.1, 0.94, and 0.56 microM, respectively.
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