Science | Nature | Cell | View More
Natural Products
2beta-(Isobutyryloxy)florilenalin
2beta-(Isobutyryloxy)florilenalin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 2beta-(Isobutyryloxy)florilenalin
Price:
CAS No.: 94898-78-9
Catalog No.: CFN91998
Molecular Formula: C19H26O5
Molecular Weight: 334.41 g/mol
Purity: >=98%
Type of Compound: Sesquiterpenoids
Physical Desc.: Powder
Source: The herbs of Centipeda minima
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Stanford University (USA)
  • Institute of Chinese Materia Me... (China)
  • Fraunhofer-Institut für Moleku... (Germany)
  • Biotech R&D Institute (USA)
  • Uniwersytet Jagielloński w Kra... (Poland)
  • Instituto de Investigaciones Ag... (Chile)
  • Universidade Federal de Santa C... (Brazil)
  • Aveiro University (Portugal)
  • Universidad de Ciencias y Artes... (Mexico)
  • University of Stirling (United Kingdom)
  • University of South Australia (Australia)
  • More...
Package
Featured Products
2-Hydroxycinnamic acid

Catalog No: CFN98193
CAS No: 614-60-8
Price: $30/20mg
Gracillin

Catalog No: CFN98537
CAS No: 19083-00-2
Price: $80/20mg
Gallic acid

Catalog No: CFN99624
CAS No: 149-91-7
Price: $30/20mg
Plantamajoside

Catalog No: CFN99522
CAS No: 104777-68-6
Price: $100/20mg
Conduritol A

Catalog No: CFN98868
CAS No: 526-87-4
Price: $258/10mg
Psoralen

Catalog No: CFN97142
CAS No: 66-97-7
Price: $30/20mg
Rebaudioside A

Catalog No: CFN99110
CAS No: 58543-16-1
Price: $40/20mg
Trigonelline

Catalog No: CFN90225
CAS No: 535-83-1
Price: $40/20mg
Ginsenoside F2

Catalog No: CFN99755
CAS No: 62025-49-4
Price: $40/20mg
Isoquercitrin

Catalog No: CFN98753
CAS No: 482-35-9
Price: $40/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: 2beta-(Isobutyryloxy)florilenalin induces apoptosis in human nasopharyngeal carcinoma CNE cells.
Targets: Bcl-2/Bax | Caspase | PARP | P450 (e.g. CYP17)
In vitro:
Molecules. 2009 Jun 12;14(6):2135-46.
2beta-(Isobutyryloxy)florilenalin, a sesquiterpene lactone isolated from the medicinal plant Centipeda minima, induces apoptosis in human nasopharyngeal carcinoma CNE cells.[Pubmed: 19553887]
Centipeda minima is a medicinal plant reputed in China as a remedy for nasopharyngeal carcinoma (NPC).
METHODS AND RESULTS:
In this study, bioactivity-guided fractionation of the anti-NPC compound(s) from C. minima led to the isolation of 2beta-(Isobutyryloxy)florilenalin (IF), a sesquiterpene lactone. IF showed significant dose- and time- dependent inhibition on the growth of the human nasopharyngeal carcinoma epithelia cells (CNE). It induced apoptosis in CNE cells, as shown by the accumulation of sub-G1 cell population, DNA fragmentation and nuclear condensation, caspase-3 activation and PARP cleavage. Such induction was associated with the depletion of mitochondrial membrane potential (DeltaPsim) and the release of cytochrome c to cytosol to regulate the expression of Bcl-2 family proteins. These activities led to the cleavage of caspases and the trigger of cell death process.
CONCLUSIONS:
Overall, IF in C. minima showed potent antiproliferative effect of C. minima on NPC cells, suggesting that the plant deserves more extensive investigation for its potential medicinal application.
2beta-(Isobutyryloxy)florilenalin Description
Source: The herbs of Centipeda minima
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Euphorbia factor L22

Catalog No: CFN95338
CAS No: 1613700-09-6
Price: $413/5mg
threo-Guaiacylglycerol-beta-conife...

Catalog No: CFN95417
CAS No: 650600-33-2
Price: $318/5mg
Pueroside C

Catalog No: CFN95156
CAS No: 112343-16-5
Price: $368/5mg
5-Hydroxy-7,8-dimethoxy (2R)-flava...

Catalog No: CFN95209
CAS No: 942626-74-6
Price: $318/10mg
11beta,13-Dihydrolactucin

Catalog No: CFN95433
CAS No: 83117-63-9
Price: $318/10mg
Parishin G

Catalog No: CFN95324
CAS No: 952283-93-1
Price: $318/10mg
Bruceoside A

Catalog No: CFN95080
CAS No: 63306-30-9
Price: $318/10mg
Eriodictyol 7-O-glucuronide

Catalog No: CFN95290
CAS No: 125535-06-0
Price: $318/10mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9903 mL 14.9517 mL 29.9034 mL 59.8068 mL 74.7585 mL
5 mM 0.5981 mL 2.9903 mL 5.9807 mL 11.9614 mL 14.9517 mL
10 mM 0.299 mL 1.4952 mL 2.9903 mL 5.9807 mL 7.4759 mL
50 mM 0.0598 mL 0.299 mL 0.5981 mL 1.1961 mL 1.4952 mL
100 mM 0.0299 mL 0.1495 mL 0.299 mL 0.5981 mL 0.7476 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
2-Hydroxycinnamic acid

Catalog No: CFN98193
CAS No: 614-60-8
Price: $30/20mg
Gracillin

Catalog No: CFN98537
CAS No: 19083-00-2
Price: $80/20mg
Gallic acid

Catalog No: CFN99624
CAS No: 149-91-7
Price: $30/20mg
Plantamajoside

Catalog No: CFN99522
CAS No: 104777-68-6
Price: $100/20mg
Conduritol A

Catalog No: CFN98868
CAS No: 526-87-4
Price: $258/10mg
Psoralen

Catalog No: CFN97142
CAS No: 66-97-7
Price: $30/20mg
Rebaudioside A

Catalog No: CFN99110
CAS No: 58543-16-1
Price: $40/20mg
Trigonelline

Catalog No: CFN90225
CAS No: 535-83-1
Price: $40/20mg
Ginsenoside F2

Catalog No: CFN99755
CAS No: 62025-49-4
Price: $40/20mg
Isoquercitrin

Catalog No: CFN98753
CAS No: 482-35-9
Price: $40/20mg
Tags: buy 2beta-(Isobutyryloxy)florilenalin | 2beta-(Isobutyryloxy)florilenalin supplier | purchase 2beta-(Isobutyryloxy)florilenalin | 2beta-(Isobutyryloxy)florilenalin cost | 2beta-(Isobutyryloxy)florilenalin manufacturer | order 2beta-(Isobutyryloxy)florilenalin | 2beta-(Isobutyryloxy)florilenalin distributor