2beta-(Isobutyryloxy)florilenalin | CAS:94898-78-9

2beta-(Isobutyryloxy)florilenalin

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Description:

2beta-(Isobutyryloxy)florilenalin induces apoptosis in human nasopharyngeal carcinoma CNE cells.

Targets:

Bcl-2/Bax | Caspase | PARP | P450 (e.g. CYP17)

In vitro:

Molecules. 2009 Jun 12;14(6):2135-46.

2beta-(Isobutyryloxy)florilenalin, a sesquiterpene lactone isolated from the medicinal plant Centipeda minima, induces apoptosis in human nasopharyngeal carcinoma CNE cells.[Pubmed: 19553887]

Centipeda minima is a medicinal plant reputed in China as a remedy for nasopharyngeal carcinoma (NPC).
METHODS AND RESULTS:
In this study, bioactivity-guided fractionation of the anti-NPC compound(s) from C. minima led to the isolation of 2beta-(Isobutyryloxy)florilenalin (IF), a sesquiterpene lactone. IF showed significant dose- and time- dependent inhibition on the growth of the human nasopharyngeal carcinoma epithelia cells (CNE). It induced apoptosis in CNE cells, as shown by the accumulation of sub-G1 cell population, DNA fragmentation and nuclear condensation, caspase-3 activation and PARP cleavage. Such induction was associated with the depletion of mitochondrial membrane potential (DeltaPsim) and the release of cytochrome c to cytosol to regulate the expression of Bcl-2 family proteins. These activities led to the cleavage of caspases and the trigger of cell death process.
CONCLUSIONS:
Overall, IF in C. minima showed potent antiproliferative effect of C. minima on NPC cells, suggesting that the plant deserves more extensive investigation for its potential medicinal application.

2beta-(Isobutyryloxy)florilenalin Description

Source:	The herbs of Centipeda minima
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	2beta-(Isobutyryloxy)florilenalin
Price:
CAS No.:	94898-78-9
Catalog No.:	CFN91998
Molecular Formula:	C₁₉H₂₆O₅
Molecular Weight:	334.41 g/mol
Purity:	>=98%
Type of Compound:	Sesquiterpenoids
Physical Desc.:	Powder
Source:	The herbs of Centipeda minima
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Sesquiterpenoids Compound Library PARP Inhibitor Library P450 (e.g. CYP17) Inhibitor Library Caspase Inhibitor Library Bcl-2/Bax Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.9903 mL	14.9517 mL	29.9034 mL	59.8068 mL	74.7585 mL
5 mM	0.5981 mL	2.9903 mL	5.9807 mL	11.9614 mL	14.9517 mL
10 mM	0.299 mL	1.4952 mL	2.9903 mL	5.9807 mL	7.4759 mL
50 mM	0.0598 mL	0.299 mL	0.5981 mL	1.1961 mL	1.4952 mL
100 mM	0.0299 mL	0.1495 mL	0.299 mL	0.5981 mL	0.7476 mL

CFN97174	4-Epi-isoinuviscolide	68832-39-3	248.3	C₁₅H₂₀O₃
CFN92943	Minimolide F	1367351-41-4	334.41	C₁₉H₂₆O₅
CFN95509	8-epi-Confertin	110115-60-1	248.3	C₁₅H₂₀O₃
CFN95523	Dihydroconfertin	68832-40-6	250.3	C₁₅H₂₂O₃
CFN95522	5-Hydroxy-4a,8-dimethyl-3-methylen-decahydroazuleno[6,5-b]furan-2(3H)-on	114579-31-6	250.3	C₁₅H₂₂O₃
CFN99345	2-Desoxy-4-epi-pulchellin	122872-03-1	250.3	C₁₅H₂₂O₃
CFN99287	Carabrolactone B	1187925-31-0	266.3	C₁₅H₂₂O₄
CFN95844	Zedoalactone A	170384-82-4	266.3	C₁₅H₂₂O₄
CFN90220	Britannin	33627-28-0	366.41	C₁₉H₂₆O₇
CFN91552	Ergolide	54999-07-4	306.4	C₁₇H₂₂O₅