3',5'-Diprenylgenistein | CAS:104055-80-3

3',5'-Diprenylgenistein

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Description:

3',5'-Diprenylgenistein inhibits protein tyrosine phosphatase 1B (PTP1B) activities, it can reduce muscle cell viability. 3',5'-Diprenylgenistein exhibits significant glucose-uptake activity in basal and insulin-stimulated L6 myotubes.

Targets:

AMPK | GLUT

In vitro:

Biol Pharm Bull. 2009 Mar;32(3):504-8.

Genistein-derivatives from Tetracera scandens stimulate glucose-uptake in L6 myotubes.[Pubmed: 19252305]

METHODS AND RESULTS:
An EtOAc-soluble partition of the MeOH extract of a branch of Tetracera scandens (Dilleniaceae family) was subjected to a glucose-uptake assay, which led to the isolation and identification of five isoflavones of previously known structure namely, genistein (1), its derivatives 3',5'-Diprenylgenistein (2), 6,8-diprenylgenistein (3), derrone (4) and alpinumisoflavone (5). Of these, compounds 2--5 exhibited significant glucose-uptake activity in basal and insulin-stimulated L6 myotubes. The findings from adenosine monophosphate-activated kinase (AMPK) activation and glucose transport protein4 (GLUT4) and GLUT1 over-expression revealed certain characteristics of compounds 2--5.
CONCLUSIONS:
These compounds inhibited protein tyrosine phosphatase 1B (PTP1B) activities with IC50 values ranging from 20.63 +/- 0.17 to 37.52 +/- 0.31 microM. No muscle cell toxicity was reported with compounds 3--5, while compounds 1 and 3',5'-Diprenylgenistein reduced muscle cell viability with IC50 values of 34.27 +/- 0.35 and 18.69 +/- 0.19 microM, respectively.

3',5'-Diprenylgenistein Description

Source:	The roots of Lupinus mutabilis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	3',5'-Diprenylgenistein
Price:
CAS No.:	104055-80-3
Catalog No.:	CFN92665
Molecular Formula:	C₂₅H₂₆O₅
Molecular Weight:	406.5 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Yellow powder
Source:	The roots of Lupinus mutabilis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Antihyperglycemic Compound Library Anti-diabetic Compound Library Flavonoids Compound Library GLUT Inhibitor Library AMPK Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.46 mL	12.3001 mL	24.6002 mL	49.2005 mL	61.5006 mL
5 mM	0.492 mL	2.46 mL	4.92 mL	9.8401 mL	12.3001 mL
10 mM	0.246 mL	1.23 mL	2.46 mL	4.92 mL	6.1501 mL
50 mM	0.0492 mL	0.246 mL	0.492 mL	0.984 mL	1.23 mL
100 mM	0.0246 mL	0.123 mL	0.246 mL	0.492 mL	0.615 mL

CFN97917	Osajin	482-53-1	404.5	C₂₅H₂₄O₅
CFN97899	8-Prenylluteone	125002-91-7	422.5	C₂₅H₂₆O₆
CFN96200	Millewanin G	874303-33-0	438.5	C₂₅H₂₆O₇
CFN96205	Millewanin H	874303-34-1	438.5	C₂₅H₂₆O₇
CFN97705	6,8-Diprenylorobol	66777-70-6	422.48	C₂₅H₂₆O₆
CFN92668	Euchrenone B1	119061-09-5	474.6	C₃₀H₃₄O₅
CFN92665	3',5'-Diprenylgenistein	104055-80-3	406.5	C₂₅H₂₆O₅
CFN96046	Derrisisoflavone B	246870-75-7	422.5	C₂₅H₂₆O₆
CFN97245	Lupalbigenin	76754-24-0	406.5	C₂₅H₂₆O₅
CFN97894	Isochandalone	121747-90-8	404.5	C₂₅H₂₄O₅