3-O-Acetyl 9,11-dehydro beta-boswellic acid | CAS:122651-20-1

3-O-Acetyl 9,11-dehydro beta-boswellic acid

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Description:

3-O-Acetyl 9,11-dehydro beta-boswellic acid has strong inhibitory activity against Jack bean urease (IC50 = 6.27 ± 0.03 μM).

In vitro:

Daru Journal of Pharmaceutical Sciences, 2013,21(1):2-2.

Urease inhibitory activities of β-boswellic acid derivatives.[Reference: WebLink]

Boswellia carterii have been used in traditional medicine for many years for management different gastrointestinal disorders. In this study, we wish to report urease inhibitory activity of four isolated compound of boswellic acid derivative.
METHODS AND RESULTS:
4 pentacyclic triterpenoid acids were isolated from Boswellia carterii and identified by NMR and Mass spectroscopic analysis (compounds 1, 3-O-acetyl-9,11-dehydro-β-boswellic acid(3-O-Acetyl 9,11-dehydro beta-boswellic acid); 2, 3-O-acetyl-11-hydroxy-β-boswellic acid; 3. 3-O- acetyl-11-keto-β-boswellic acid and 4, 11-keto-β-boswellic acid. Their inhibitory activity on Jack bean urease were evaluated. Docking and pharmacophore analysis using AutoDock 4.2 and Ligandscout 3.03 programs were also performed to explain possible mechanism of interaction between isolated compounds and urease enzyme. It was found that compound 1 has the strongest inhibitory activity against Jack bean urease (IC50 = 6.27 ± 0.03 μM), compared with thiourea as a standard inhibitor (IC50 = 21.1 ± 0.3 μM).
CONCLUSIONS:
The inhibition potency is probably due to the formation of appropriate hydrogen bonds and hydrophobic interactions between the investigated compounds and urease enzyme active site and confirms its traditional usage.

3-O-Acetyl 9,11-dehydro beta-boswellic acid Description

Source:	The herbs of Boswellia carterii Birdw.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	3-O-Acetyl 9,11-dehydro beta-boswellic acid
Price:
CAS No.:	122651-20-1
Catalog No.:	CFN70260
Molecular Formula:	C₃₂H₄₈O₄
Molecular Weight:	496.7 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The herbs of Boswellia carterii Birdw.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Triterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.0133 mL	10.0664 mL	20.1329 mL	40.2658 mL	50.3322 mL
5 mM	0.4027 mL	2.0133 mL	4.0266 mL	8.0532 mL	10.0664 mL
10 mM	0.2013 mL	1.0066 mL	2.0133 mL	4.0266 mL	5.0332 mL
50 mM	0.0403 mL	0.2013 mL	0.4027 mL	0.8053 mL	1.0066 mL
100 mM	0.0201 mL	0.1007 mL	0.2013 mL	0.4027 mL	0.5033 mL

CFN90221	Beta-boswellic acid	631-69-6	456.70	C₃₀H₄₈O₃
CFN90530	3-O-Acetyl-beta-boswellic acid	5968-70-7	498.74	C₃₂H₅₀O₄
CFN90152	11-Keto-beta-boswellic acid	17019-92-0	470.68	C₃₀H₄₆O₄
CFN90531	3-O-Acetyl-11-keto-beta-boswellic acid	67416-61-9	512.72	C₃₂H₄₈O₅
CFN95335	9,11-Dehydro-beta-boswellic acid	471-65-8	454.7	C₃₀H₄₆O₃
CFN70260	3-O-Acetyl 9,11-dehydro beta-boswellic acid	122651-20-1	496.7	C₃₂H₄₈O₄
CFN98562	Roburic acid	6812-81-3	440.71	C₃₀H₄₈O₂
CFN97681	Dulcioic acid	78516-69-5	456.71	C₃₀H₄₈O₃
CFN99881	Triptocallic acid A	190906-61-7	472.7	C₃₀H₄₈O₄
CFN99821	22-Hydroxy-3-oxo-12-ursen-30-oic acid	173991-81-6	470.7	C₃₀H₄₆O₄