Science | Nature | Cell | View More
Natural Products
5'-Demethylaquillochin
5'-Demethylaquillochin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 5'-Demethylaquillochin
Price:
CAS No.: 305364-91-4
Catalog No.: CFN98388
Molecular Formula: C20H18O9
Molecular Weight: 402.4 g/mol
Purity: >=98%
Type of Compound: Coumarins
Physical Desc.: Powder
Source: The herbs of Mallotus apelta
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Institute of Bioorganic Chemist... (Poland)
  • Almansora University (Egypt)
  • Subang Jaya Medical Centre (Malaysia)
  • Shanghai University of TCM (China)
  • Griffith University (Australia)
  • University of Lodz (Poland)
  • University of Vienna (Austria)
  • University of Mysore (India)
  • Siksha O Anusandhan University (India)
  • Shanghai Institute of Organic C... (China)
  • University of Illinois at Chicago (USA)
  • More...
Package
Featured Products
Bavachinin

Catalog No: CFN98006
CAS No: 19879-30-2
Price: $80/20mg
Intermedine N-oxide

Catalog No: CFN00459
CAS No: 95462-14-9
Price: $ / mg
Ginsenoside Rb1

Catalog No: CFN99964
CAS No: 41753-43-9
Price: $40/20mg
Timosaponin A3

Catalog No: CFN98151
CAS No: 41059-79-4
Price: $50/20mg
Celastrol

Catalog No: CFN99198
CAS No: 34157-83-0
Price: $40/20mg
alpha-Mangostin

Catalog No: CFN97050
CAS No: 6147-11-1
Price: $40/20mg
Soybean phospholipid

Catalog No: CFN93800
CAS No: 8002-43-5
Price: $30/20mg
3-Hydroxy-4-methoxycinnamic acid

Catalog No: CFN99135
CAS No: 537-73-5
Price: $30/20mg
Ginsenoside Rk1

Catalog No: CFN92644
CAS No: 494753-69-4
Price: $188/20mg
1-O-Acetyl britannilactone

Catalog No: CFN90219
CAS No: 681457-46-5
Price: $338/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: 5'-Demethylaquillochin and its isomer from the dichloromethane extract of E. cavaleriei have potential as chemopreventive agents through induction of detoxification enzymes. 5'-Demethylaquillochin exhibits the most potential chemopreventive ability.
Targets: NADPH-oxidase | SOD
In vitro:
J Chromatogr A. 2009 Jun 12;1216(24):4859-67.
Characterization of chemopreventive agents from the dichloromethane extract of Eurycorymbus cavaleriei by liquid chromatography-ion trap mass spectrometry.[Pubmed: 19439309]

METHODS AND RESULTS:
The relative ability to induce the detoxification enzyme, NAD(P)H:quinone oxidoreductase 1 (NQO1) of nine coumarin compounds was tested which also showed 5'-Demethylaquillochin exhibited the most potential chemopreventive ability.
CONCLUSIONS:
These observations suggest that 5'-Demethylaquillochin and its isomer from the dichloromethane extract of E. cavaleriei have potential as chemopreventive agents through induction of detoxification enzymes.
Chem Biodivers. 2008 Apr;5(4):591-7.
New hepatoprotective coumarinolignoids from Mallotus apelta.[Pubmed: 18421750]

METHODS AND RESULTS:
Three new coumarinolignoids, malloapelins A-C (1-3, resp.), together with three known coumarinolignoids, cleomiscosin A (4), cleomiscosin B (5), and 5'-Demethylaquillochin (6), were isolated from the roots of Mallotus apelta MUELL.-ARG. Compounds 1-6 are three pairs of regioisomeric coumarinolignoids. Their structures were elucidated on the basis of spectral evidence.
CONCLUSIONS:
Compounds 3 showed promising hepatoprotective activity against D-galactosamine-induced toxicity in WB-F344 rat hepatic epithelial stem-like cells.
5'-Demethylaquillochin Description
Source: The herbs of Mallotus apelta
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
cis-Aegineoside

Catalog No: CFN95295
CAS No: N/A
Price: $413/5mg
3',8-Dihydroxyvestitol

Catalog No: CFN95384
CAS No: 122587-87-5
Price: $413/5mg
Kihadanin D

Catalog No: CFN95482
CAS No: 2770024-83-2
Price: $413/5mg
New compound 14

Catalog No: CFN95381
CAS No: N/A
Price: $413/5mg
Apigenin-6-C-beta-D-glucopyranosyl...

Catalog No: CFN95540
CAS No: 1646598-06-2
Price: $368/5mg
Somnifericin

Catalog No: CFN95280
CAS No: 173693-57-7
Price: $318/5mg
Dactylorhin A

Catalog No: CFN95032
CAS No: 256459-34-4
Price: $238/20mg
3'-Hydroxy-2,4,5-trimethoxydalberg...

Catalog No: CFN95410
CAS No: N/A
Price: $413/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.4851 mL 12.4254 mL 24.8509 mL 49.7018 mL 62.1272 mL
5 mM 0.497 mL 2.4851 mL 4.9702 mL 9.9404 mL 12.4254 mL
10 mM 0.2485 mL 1.2425 mL 2.4851 mL 4.9702 mL 6.2127 mL
50 mM 0.0497 mL 0.2485 mL 0.497 mL 0.994 mL 1.2425 mL
100 mM 0.0249 mL 0.1243 mL 0.2485 mL 0.497 mL 0.6213 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
J Nat Med. 2011 Jan;65(1):191-3.
Aromatic compounds and their antioxidant activity of Acer saccharum.[Pubmed: 20686865]

METHODS AND RESULTS:
A new lignan glycoside, 5-(3″,4″-dimethoxy-phenyl)-3-hydroxy-3-(4'-hydroxy-3'-methoxybenzyl)-4-hydroxymethyl-dihydrofuran-2-one 4'-O-α-L: -rhamnopyranoside (1), with seven known compounds, compound 2, koaburside, icariside E(4), cleomiscosin C, cleomiscosin D, scopoletin, and 5'-Demethylaquillochin, were isolated from the EtOH extract of the wood of Acer saccharum (Aceraceae). Their structures were determined by 1D and 2D nuclear magnetic resonance (NMR) and mass spectroscopy analysis.
CONCLUSIONS:
All of the isolated compounds, 1-8, were tested for their antioxidant activity in superoxide dismutase (SOD)-like assay.
Fitoterapia. 2000 Jun;71(3):341-2.
Coumarinolignoids of Mallotus apelta.[Pubmed: 10844178]

METHODS AND RESULTS:
Three coumarino-lignoids, aquillochin (1), cleomiscosin A and 5'-Demethylaquillochin have been isolated from Mallotus apelta. The structure of the new compound 3 was determined by spectroscopic techniques.
Bavachinin

Catalog No: CFN98006
CAS No: 19879-30-2
Price: $80/20mg
Intermedine N-oxide

Catalog No: CFN00459
CAS No: 95462-14-9
Price: $ / mg
Ginsenoside Rb1

Catalog No: CFN99964
CAS No: 41753-43-9
Price: $40/20mg
Timosaponin A3

Catalog No: CFN98151
CAS No: 41059-79-4
Price: $50/20mg
Celastrol

Catalog No: CFN99198
CAS No: 34157-83-0
Price: $40/20mg
alpha-Mangostin

Catalog No: CFN97050
CAS No: 6147-11-1
Price: $40/20mg
Soybean phospholipid

Catalog No: CFN93800
CAS No: 8002-43-5
Price: $30/20mg
3-Hydroxy-4-methoxycinnamic acid

Catalog No: CFN99135
CAS No: 537-73-5
Price: $30/20mg
Ginsenoside Rk1

Catalog No: CFN92644
CAS No: 494753-69-4
Price: $188/20mg
1-O-Acetyl britannilactone

Catalog No: CFN90219
CAS No: 681457-46-5
Price: $338/20mg
Tags: buy 5'-Demethylaquillochin | 5'-Demethylaquillochin supplier | purchase 5'-Demethylaquillochin | 5'-Demethylaquillochin cost | 5'-Demethylaquillochin manufacturer | order 5'-Demethylaquillochin | 5'-Demethylaquillochin distributor