6,4'-Dihydroxy-7-methoxyflavanone | CAS:189689-32-5

6,4'-Dihydroxy-7-methoxyflavanone

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Description:

6,4'-Dihydroxy-7-methoxyflavanone has antioxidant, anti-inflammatory and neuroprotective effects. It shows inhibition of osteoclasts differentiation and function, it can be a potential therapeutic molecule for osteoclastogenic bone diseases such osteoporosis, rheumatoid arthritis and periodontal diseases.

Targets:

NF-kB | HO-1 | MAPK | JNK | PGE | TNF-α | IL Receptor | ERK

In vitro:

Eur J Pharmacol. 2012 Jan 15;674(2-3):153-62.

Involvement of heme oxygenase-1 induction in the cytoprotective and immunomodulatory activities of 6,4'-dihydroxy-7-methoxyflavanone in murine hippocampal and microglia cells.[Pubmed: 22119385]

6,4'-Dihydroxy-7-methoxyflavanone (DMF), a biologically active compound, was isolated from the heartwood of Dalbergia odorifera T. Chen (Leguminosae).
METHODS AND RESULTS:
The present study proposed to examine the role of DMF as an anti-oxidative and anti-inflammatory heme oxygenase-1 (HO-1) inducer in mouse hippocampal HT22 cells and BV2 microglia cells. The effect of DMF on cell viability was determined by MTT assay and the effects of DMF on pro-inflammatory enzymes and cytokines were analyzed by western blot and ELISA. Parameters such as DMF induced HO-1 protein immunocontents, HO activity and mitogen-activated protein kinases (MAPK) activation were also measured. DMF increased cellular resistance to oxidative injury caused by glutamate-induced cytotoxicity in HT22 cells, via JUN N-terminal kinase (JNK) pathway dependent HO-1 expression. Furthermore, DMF suppressed the lipopolysaccharide (LPS)-induced expression of pro-inflammatory enzymes and inflammatory mediators in BV2 microglia. DMF suppressed production of nitric oxide (NO), prostaglandin E2 (PGE(2)), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), through extracellular signal-regulated kinase (ERK) pathway dependent HO-1 expression.
CONCLUSIONS:
This study indicates that DMF effectively modulates the regulation of anti-oxidative and anti-inflammatory action, via up-regulation of HO-1 in HT22 cells and BV2 microglia. These results suggest that DMF possesses therapeutic potentials against neurodegenerative diseases that are induced by oxidative stress and neuroinflammation.

6,4'-Dihydroxy-7-methoxyflavanone Description

Source:	The heartwoods of Dalbergia odorifera.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Biol Pharm Bull. 2013;36(5):796-801.

6,4'-Dihydroxy-7-methoxyflavanone inhibits osteoclast differentiation and function.[Pubmed: 23420617]

6,4'-Dihydroxy-7-methoxyflavanone (DMF) is a flavonoid isolated from Heartwood Dalbergia odorifera. It has been known that DMF has antioxidant, anti-inflammatory and neuroprotective effects. DMF, however, the efficacy of bone related diseases has not been reported.
METHODS AND RESULTS:
In this study, we determined DMF's efficacy on osteoclasts differentiation and function using in vitro bone marrow macrophage osteoclast differentiation culture system. DMF inhibited receptor activators of nuclear factor kappa-B ligand (RANKL) induced osteoclastogenesis dose dependently. In addition, DMF decreased osteoclast function through disruption of actin ring formation and consequently suppression of the pit-forming activity of mature osteoclasts. Mechanistically, DMF inhibited RANKL-induced expression of nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (NFATc1) and c-Fos via inhibition of mitogen activated protein kinases (MAPKs) pathway.
CONCLUSIONS:
Collectively, the inhibition of osteoclasts differentiation and function by DMF suggests that DMF can be a potential therapeutic molecule for osteoclastogenic bone diseases such osteoporosis, rheumatoid arthritis and periodontal diseases.

Product Name	6,4'-Dihydroxy-7-methoxyflavanone
Price:
CAS No.:	189689-32-5
Catalog No.:	CFN89523
Molecular Formula:	C₁₆H₁₄O₅
Molecular Weight:	286.27 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The heartwoods of Dalbergia odorifera.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Antioxidants Compound Library Neuroprotection Compound Library Anti-osteoclastogenesis Compound Library Flavonoids Compound Library TNF-α Inhibitor Library PGE Inhibitor Library NF-kB Inhibitor Library MAPK Inhibitor Library JNK Inhibitor Library IL Receptor Inhibitor Library HO-1 Inhibitor Library ERK Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.4932 mL	17.466 mL	34.9321 mL	69.8641 mL	87.3301 mL
5 mM	0.6986 mL	3.4932 mL	6.9864 mL	13.9728 mL	17.466 mL
10 mM	0.3493 mL	1.7466 mL	3.4932 mL	6.9864 mL	8.733 mL
50 mM	0.0699 mL	0.3493 mL	0.6986 mL	1.3973 mL	1.7466 mL
100 mM	0.0349 mL	0.1747 mL	0.3493 mL	0.6986 mL	0.8733 mL

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CFN98603	Naringenin triacetate	3682-04-0	398.4	C₂₁H₁₈O₈
CFN97060	5-O-Methylnaringenin	61775-19-7	286.3	C₁₆H₁₄O₅
CFN98366	Sakuranetin	2957-21-3	286.3	C₁₆H₁₄O₅
CFN98743	Isosakuranetin	480-43-3	286.3	C₁₆H₁₄O₅
CFN96126	Tsugafolin	66568-97-6	300.3	C₁₇H₁₆O₅
CFN98364	4',7-Di-O-methylnaringenin	29424-96-2	300.3	C₁₇H₁₆O₅
CFN98616	Naringenin trimethyl ether	38302-15-7	314.3	C₁₈H₁₈O₅
CFN97529	6-Methoxynaringenin	94942-49-1	302.3	C₁₆H₁₄O₆
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