Columbianetin beta-D-glucopyranoside | CAS:55836-35-6

Columbianetin beta-D-glucopyranoside

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Description:

Columbianetin-beta-D-glucopyranoside exhibits anti-inflammatory and analgesic properties, it also shows strong inhibiting activity against platelet aggregation.

Targets:

Immunology & Inflammation related

In vitro:

Yao Xue Xue Bao. 1989;24(7):546-51.

Studies of the active constituents of the Chinese drug [Pubmed: 2618698]

METHODS AND RESULTS:
Eight coumarins isolated from the alcohol extract of the Chinese drug "Duhuo", the root of Angelica pubescents Maxim. f. biserrata Shan et Yuan (Umbelliferae) were elucidated to be columbianetin (I), columbianetin acetate (II), columbiadin (III), osthol (IV), isoimperatorin (V), bergapten (VI), xanthotoxin (VII), and Columbianetin beta-D-glucopyranoside (VIII), by chemical and spectral analysis, compound VIII was isolated from plant for the first time.
CONCLUSIONS:
All these coumarins were tested on platelet aggregation induced by 2 microns ADP. I, II, III, IV and VIII showed strong inhibiting activity against platelet aggregation.

Columbianetin beta-D-glucopyranoside Description

Source:	The roots of Angelica gigas
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

J Pharm Biomed Anal. 2018 May 10;153:221-231.

Simultaneous determination of columbianetin-β-d-glucopyranoside and columbianetin in a biological sample by high-performance liquid chromatography with fluorescence detection and identification of other columbianetin-β-d-glucopyranoside metabolites by u[Pubmed: 29506005]

Columbianetin beta-D-glucopyranoside (CBG) and its metabolite columbianetin (CBN) are the bioactive constituents of Angelicae pubescentis radix (APR). They exhibit the anti-platelet aggregation, anti-inflammatory and analgesic properties. The absorption, distribution, metabolism and excretion (ADME) of CBG has not been reported to date.
METHODS AND RESULTS:
Both high-performance liquid chromatography with fluorescence detection and ultra high-performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry methods were developed and validated for the study of ADME of CBG. It was found that CBG could be catabolized into its active metabolite CBN in vivo. The absolute bioavailability of columbianetin-β-d-glucopyranoside was 5.63 ± 4.42%. The other co-existing constituents from the APR ethanol extract could enhance the absorption of CBG. CBG and CBN were rapidly and broadly distributed in the stomach, ovary, kidney, liver, spleen, lung, muscles, heart and brain. Higher levels of accumulation of CBG and CBN were detected in the ovary and kidney tissues. Eight metabolites of CBG were tentatively identified in blood, urine, bile and faeces of rats after oral administration of pure CBG. It was also found that CBG and CBN were mainly excreted through the faecal route.
CONCLUSIONS:
It can be concluded that the validated methods were successfully applied for absorption, distribution, metabolism and excretion study of CBG.

Product Name	Columbianetin beta-D-glucopyranoside
Price:	$288 / 5mg
CAS No.:	55836-35-6
Catalog No.:	CFN95038
Molecular Formula:	C₂₀H₂₄O₉
Molecular Weight:	408.4 g/mol
Purity:	>=98%
Type of Compound:	Coumarins
Physical Desc.:	Powder
Source:	The roots of Angelica gigas
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Coumarins Compound Library Immunology & Inflammation related Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.4486 mL	12.2429 mL	24.4858 mL	48.9716 mL	61.2145 mL
5 mM	0.4897 mL	2.4486 mL	4.8972 mL	9.7943 mL	12.2429 mL
10 mM	0.2449 mL	1.2243 mL	2.4486 mL	4.8972 mL	6.1214 mL
50 mM	0.049 mL	0.2449 mL	0.4897 mL	0.9794 mL	1.2243 mL
100 mM	0.0245 mL	0.1224 mL	0.2449 mL	0.4897 mL	0.6121 mL

CFN95038	Columbianetin beta-D-glucopyranoside	55836-35-6	408.4	C₂₀H₂₄O₉
CFN95005	Apterin	53947-89-0	424.4	C₂₀H₂₄O₁₀
CFN95272	Peucenidin	33044-93-8	386.4	C₂₁H₂₂O₇
CFN95273	Isoedultin	43043-08-9	386.4	C₂₁H₂₂O₇
CFN95274	9-Hydroxy-O-senecioyl-8,9-dihydrooroselol	31456-63-0	344.4	C₁₉H₂₀O₆
CFN95275	Daucoidin A	103629-87-4	344.4	C₁₉H₂₀O₆
CFN95123	3'-Angeloyloxy-4'-senecioyloxy-2',3'-dihydrooroselol	1221686-60-7	426.5	C₂₄H₂₆O₇
CFN91414	Oroselone	1760-27-6	226.2	C₁₄H₁₀O₃
CFN95001	Oroselol	1891-25-4	244.2	C₁₄H₁₂O₄
CFN90185	Columbianetin	3804-70-4	246.26	C₁₄H₁₄O₄