6-Hydroxysugiol | CAS:55898-07-2 | Manufacturer ChemFaces

6-Hydroxysugiol

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Description:

6-Hydroxysugiol inhibits proliferation and migration of HepG2 cells and exhibits potent anti-angiogenic activity.

Targets:

VEGFR

In vitro:

Latin American Journal of Pharmacy, 2012 , 31 (10) :1457-1463.

6-Hydroxysugiol Isolated from Salvia yunnanensis Inhibits Proliferation and Migration of HepG2 Cells as well as Exhibits Potent Anti-Angiogenic Activity[Reference: WebLink]

The aim of our study was to investigate the anti-angiogenic effect and anti-tumor activity of 6-Hydroxysugiol isolated from Salvia yunnanensis.
METHODS AND RESULTS:
The cell proliferation was evaluated by MTT assay. The apoptosis of HepG2 was studied through the fluorescence microscope. Anti-angiogenic activity of 6-Hydroxysugiol was tested by chicken chorioallantoic membrane (CAM) model in vivo. In order to study the mechanism of 6-Hydroxysugiol inhibiting angiogenesis, the expression of VEGF in the HepG2 cell and the cell culture fluid were determined by immunocytochemistry and ELISA assay. The results showed that the cell proliferation was inhibited to 76.2% by 6-Hydroxysugiol, at the concentration 0.32 mmol/L. The ability of cells to migrate was significantly reduced by 6-Hydroxysugiol and the 59.72% cells showed the typically apoptotic chromatin fragmentation that were treated with 6-Hydroxysugiol at 0.64 mmol/L. The ex- pression of VEGF in the HepG2 cell and in the cell culture medium were all decreased to by 6-Hydroxysugiol.
CONCLUSIONS:
6-Hydroxysugiol is able to suppress angiogenesis on CAM models. These results suggest that it is de- served further investigation as a promising anti-tumor angiogenesis compound.

6-Hydroxysugiol Description

Source:	The herbs of Salvia yunnanensis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Synthesis , 2010 (13) :2223-2232.

Connecting C19 Norditerpenoids to C20 Diterpenes: Total Syntheses of 6Hydroxy5,6-dehydrosugiol, 6-Hydroxysugiol, and Taiwaniaquinone H, and Formal Synthesis of Dichroanone[Reference: WebLink]

METHODS AND RESULTS:
Oxidation of the B-ring of abietane derivatives by Sharpless- dihydroxylation gave the natural products 6-hydroxy-5,6-dehydrosugiol and 6-Hydroxysugiol. Moreover, further oxidation gave a hydroxy dione derivative that provides a synthetic entry into the C19 taiwaniaquinoid family of natural products.
CONCLUSIONS:
This route is based on biosynthetic considerations and involves a benzilic acid rearrangement followed by decarboxylation. On the basis of this approach, a total synthesis of (-)-taiwaniaquinone H and a formal synthesis of (-)-dichroanone have been achieved.

Product Name	6-Hydroxysugiol
Price:
CAS No.:	55898-07-2
Catalog No.:	CFN92177
Molecular Formula:	C₂₀H₂₈O₃
Molecular Weight:	316.4 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The herbs of Salvia yunnanensis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-proliferation Compound Library Antiangiogenic Compound Library Anti-migration Compound Library Diterpenoids Compound Library VEGFR Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.1606 mL	15.8028 mL	31.6056 mL	63.2111 mL	79.0139 mL
5 mM	0.6321 mL	3.1606 mL	6.3211 mL	12.6422 mL	15.8028 mL
10 mM	0.3161 mL	1.5803 mL	3.1606 mL	6.3211 mL	7.9014 mL
50 mM	0.0632 mL	0.3161 mL	0.6321 mL	1.2642 mL	1.5803 mL
100 mM	0.0316 mL	0.158 mL	0.3161 mL	0.6321 mL	0.7901 mL

CFN92178	Ferruginol	514-62-5	286.5	C₂₀H₃₀O
CFN92329	15-Hydroxyferruginol	76235-93-3	302.5	C₂₀H₃₀O₂
CFN98948	Hinokiol	564-73-8	302.5	C₂₀H₃₀O₂
CFN95814	3alpha-Hinokiol	107740-34-1	302.5	C₂₀H₃₀O₂
CFN92978	2beta-Acetoxyferruginol	1206461-56-4	344.49	C₂₂H₃₂O₃
CFN92187	Sugiol	511-05-7	300.4	C₂₀H₂₈O₂
CFN95803	16-Acetoxylsugiol	1413941-65-7	358.5	C₂₂H₃₀O₄
CFN95805	Gerardianin B	2070919-73-0	390.5	C₂₂H₃₀O₆
CFN95831	16-Acetoxy-7alpha-methoxyroyleanone	109974-33-6	404.5	C₂₃H₃₂O₆
CFN92177	6-Hydroxysugiol	55898-07-2	316.4	C₂₀H₂₈O₃