7-O-Acetylintermedine N-oxide | CAS:685132-59-6

7-O-Acetylintermedine N-oxide

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Description:

7-O-Acetylintermedine-N-oxide is a pyrrolizidine alkaloid isolated from Symphytum officinale. Pyrrolizidine alkaloids have adverse health effects and were classified as genotoxic, carcinogen and hepatotoxic.

In vivo:

EFSA Journal 2011;9(11):2406.

Scientific Opinion on Pyrrolizidine alkaloids in food and feed[Reference: WebLink]

The European Food Safety Authority (EFSA) was asked by the European Commission to deliver a scientific opinion on pyrrolizidine alkaloids (PA) in food and feed. PAs are toxins exclusively biosynthesised by plants. To date, approximately 600 different PAs are known. Results for 13,280 bulk honey and 1324 retail honey samples were provided to EFSA by one Member State and 351 feed samples were provided by a second Member State. The EFSA Panel on Contaminants in the Food Chain (CONTAM Panel) performed estimates of both acute and chronic exposure to PAs through honey for three different age groups. Although there might be other sources of PA exposure, due to lack of data the CONTAM Panel was not able to quantify dietary exposure from food other than honey. A number of PAs were identified as being of particular importance for food and feed. Based on the present knowledge of metabolism, activation, DNA adduct-formation, genotoxicity and carcinogenicity, the CONTAM Panel concluded that 1,2-unsaturated PAs may act as genotoxic carcinogens in humans. Therefore, the CONTAM Panel decided to apply the Margin of Exposure (MOE) approach. A benchmark dose lower confidence limit for a 10 % excess cancer risk (BMDL10) of 70 μg/kg b.w. per day for induction of liver haemangiosarcomas by lasiocarpine in male rats was calculated as the reference point for comparison with the estimated dietary exposure. The CONTAM Panel concluded that there is a possible health concern for those toddlers and children who are high consumers of honey. There is generally a low risk of PA poisoning in livestock and companion animals in the EU as most PA poisonings reported recently are due to accidental exposure.

7-O-Acetylintermedine N-oxide Description

Source:	The herbs of Echium pininana
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	7-O-Acetylintermedine N-oxide
Price:
CAS No.:	685132-59-6
Catalog No.:	CFN00518
Molecular Formula:	C₁₇H₂₇NO₇
Molecular Weight:	357.4 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The herbs of Echium pininana
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.798 mL	13.9899 mL	27.9799 mL	55.9597 mL	69.9496 mL
5 mM	0.5596 mL	2.798 mL	5.596 mL	11.1919 mL	13.9899 mL
10 mM	0.2798 mL	1.399 mL	2.798 mL	5.596 mL	6.995 mL
50 mM	0.056 mL	0.2798 mL	0.5596 mL	1.1192 mL	1.399 mL
100 mM	0.028 mL	0.1399 mL	0.2798 mL	0.5596 mL	0.6995 mL

CFN00288	7-Acetyllycopsamine	73544-48-6	341.40	C₁₇H₂₇NO₆
CFN00277	Petasinoside	70474-34-9	531.60	C₂₈H₃₇NO₉
CFN00278	Thesinine	488-02-8	287.36	C₁₇H₂₁NO₃
CFN00282	Ehretinine	76231-29-3	275.35	C₁₆H₂₁NO₃
CFN00283	Indicine	480-82-0	299.36	C₁₅H₂₅NO₅
CFN00284	Indicine N-oxide	41708-76-3	315.37	C₁₅H₂₅NO₆
CFN00285	Intermedine	10285-06-0	299.36	C₁₅H₂₅NO₅
CFN00459	Intermedine N-oxide	95462-14-9	315.4	C₁₅H₂₅NO₆
CFN00286	7-Acetylintermedine	74243-01-9	341.40	C₁₇H₂₇NO₆
CFN00518	7-O-Acetylintermedine N-oxide	685132-59-6	357.4	C₁₇H₂₇NO₇