9-Dihydro-13-acetylbaccatin III | CAS:142203-65-4

9-Dihydro-13-acetylbaccatin III

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Description:

9-Dihydro-13-acetylbaccatin III shows cytotoxicity against the MCF7 cell line and drug resistant cell line MCF7-ADR.

In vitro:

Bioorg Med Chem. 2003 Apr 3;11(7):1551-6.

Semi-synthesis of an O-glycosylated docetaxel analogue.[Pubmed: 12628678]

A 7beta-O-glycosylated docetaxel analogue was semi-synthesized from 9-Dihydro-13-acetylbaccatin III, the most abundant taxane isolated from the needles of Taxus canadensis.
METHODS AND RESULTS:
It was shown to be more bioactive than paclitaxel according to the tubulin assay. It had a reduced potency in the MCF7 cell line cytotoxicity assay compared to paclitaxel, but it demonstrated better activity against the drug resistant cell line MCF7-ADR. In addition, the presence of one sugar moiety on C-7 doubled the water solubility versus that of paclitaxel.

9-Dihydro-13-acetylbaccatin III Description

Source:	The herbs of Taxus canadensis.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	9-Dihydro-13-acetylbaccatin III
Price:	$118 / 20mg
CAS No.:	142203-65-4
Catalog No.:	CFN89062
Molecular Formula:	C₃₃H₄₂O₁₂
Molecular Weight:	630.68 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The herbs of Taxus canadensis.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Cytotoxic Compound Library Anti-multidrug resistance Compound Library Diterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.5856 mL	7.928 mL	15.8559 mL	31.7118 mL	39.6398 mL
5 mM	0.3171 mL	1.5856 mL	3.1712 mL	6.3424 mL	7.928 mL
10 mM	0.1586 mL	0.7928 mL	1.5856 mL	3.1712 mL	3.964 mL
50 mM	0.0317 mL	0.1586 mL	0.3171 mL	0.6342 mL	0.7928 mL
100 mM	0.0159 mL	0.0793 mL	0.1586 mL	0.3171 mL	0.3964 mL

CFN89062	9-Dihydro-13-acetylbaccatin III	142203-65-4	630.68	C₃₃H₄₂O₁₂
CFN96925	Baccatin VI	57672-79-4	714.76	C₃₇H₄₆O₁₄
CFN96907	Baccatin VIII	1623410-10-5	646.68	C₃₃H₄₂O₁₃
CFN98976	Baccatin IV	57672-77-2	652.7	C₃₂H₄₄O₁₄
CFN98421	10-Deacetylbaccatin III	32981-86-5	544.6	C₂₉H₃₆O₁₀
CFN98331	Baccatin III	27548-93-2	586.6	C₃₁H₃₈O₁₁
CFN97267	19-Hydroxybaccatin III	78432-78-7	602.6	C₃₁H₃₈O₁₂
CFN89390	7-Xylosyl-10-deacetylbaccatin III	157664-03-4	676.70	C₃₄H₄₄O₁₄
CFN96908	Baccatin IX	1623410-12-7	604.64	C₃₁H₄₀O₁₂
CFN96909	Baccatin X	1623069-76-0	604.64	C₃₁H₄₀O₁₂