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Agatharesinol
Agatharesinol
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Product Name Agatharesinol
Price:
CAS No.: 7288-11-1
Catalog No.: CFN97696
Molecular Formula: C17H18O4
Molecular Weight: 286.33 g/mol
Purity: >=98%
Type of Compound: Lignans
Physical Desc.: Powder
Source: The barks of Cryptomeria japonica
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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Related Screening Libraries
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Biological Activity
Description: Agatharesinol is localized in the ray parenchyma cells in Sugi heartwood, and differences between the chemical structure of the contents of ray and axial parenchyma cells were also suggested.
In vitro:
Phytochemistry. 2002 Jul;60(5):461-6.
Immunohistochemical localization of agatharesinol, a heartwood norlignan, in Cryptomeria japonica.[Pubmed: 12052511]

METHODS AND RESULTS:
Localization of a heartwood norlignan, Agatharesinol, in Sugi (Japanese cedar, Cryptomeria japonica D. Don, Taxodiaceae) was investigated by immunohistochemistry. Immuno light microscopy showed that the contents of ray parenchyma cells were immunostained in heartwood but not in sapwood. The staining of the heartwood tissue was competitively inhibited by Agatharesinol but not by other Sugi heartwood extractives, and was, furthermore, markedly reduced by pre-extraction of the tissue with MeOH. These results indicated that the staining can be ascribed to the immunolabeling of Agatharesinol in situ. The accumulations over the inner surface of some tracheid cell walls adjacent to the ray parenchyma cells were also immunolabeled, while the contents in axial parenchyma cells were not.
CONCLUSIONS:
In conclusion, Agatharesinol was localized in the ray parenchyma cells in Sugi heartwood, and differences between the chemical structure of the contents of ray and axial parenchyma cells were also suggested.
Agatharesinol Description
Source: The barks of Cryptomeria japonica
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.4925 mL 17.4624 mL 34.9247 mL 69.8495 mL 87.3118 mL
5 mM 0.6985 mL 3.4925 mL 6.9849 mL 13.9699 mL 17.4624 mL
10 mM 0.3492 mL 1.7462 mL 3.4925 mL 6.9849 mL 8.7312 mL
50 mM 0.0698 mL 0.3492 mL 0.6985 mL 1.397 mL 1.7462 mL
100 mM 0.0349 mL 0.1746 mL 0.3492 mL 0.6985 mL 0.8731 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
J Plant Physiol. 2006 Mar;163(5):483-7.
Evidence for involvement of the phenylpropanoid pathway in the biosynthesis of the norlignan agatharesinol.[Pubmed: 16473652]
In order to study the biosynthesis of Agatharesinol, a norlignan, l-phenylalanine-[ring-2,3,4,5,6-2H] and trans-cinnamic acid-[ring-13C6] were administered to fresh sapwood sticks of Cryptomeria japonica (sugi, Japanese cedar), that is, the labeled precursors were allowed to be absorbed through the tangential section of the wood sticks.
METHODS AND RESULTS:
The wood sticks were then maintained in high humidity desiccators for approximately 20 d after which ethyl acetate (EtOAc) extracts of the wood sticks were analyzed by gas chromatography-mass spectrometry (GC-MS). Native Agatharesinol (trimethylsilylated) produces an m/z 369 ion and an m/z 484 ion that are characteristic of its structure. Agatharesinol formed in the sapwood sticks treated with the deuterium-labeled l-phenylalanine generated both of these ions together with m/z 373 and 377 ions (m/z 369+4 and +8, respectively), and also m/z 488 and 492 ions (m/z 484+4 and +8, respectively). Generation of m/z 373 and 488 ions is attributed to the substitution by deuterium of the four hydrogen atoms of either of the p-hydroxyphenyl rings of Agatharesinol, and that of m/z 377 and 492 ions is attributed to the substitution by deuterium of the eight hydrogen atoms of both p-hydroxyphenyl rings. In the administration of the 13C-labeled trans-cinnamic acid, m/z 375 and 381 ions (m/z 369+6 and +12, respectively), and also m/z 490 and 496 ions (m/z 484+6 and +12, respectively) were found, indicating that either aromatic ring or both aromatic rings of Agatharesinol were 13C-labeled.
CONCLUSIONS:
Consequently, assimilation of the labeled precursors into Agatharesinol was clearly detected, and an experimental procedure for studies on the biosynthesis was developed.
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