Alopecurone A | CAS:162558-89-6 | Manufacturer ChemFaces

Alopecurone A

ChemFaces products have been cited in many studies from excellent and top scientific journals

Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC

How to Order

Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com

Delivery time

Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal

Citing Use of our Products

More Impact Factor than five Cite...

* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $251.2 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

Featured Products

More...

Protodioscin

Catalog No: CFN99517
CAS No: 55056-80-9
Price: $50/20mg

1-O-Acetylbritannilactone

Catalog No: CFN89438
CAS No: 33627-41-7
Price: $218/20mg

Isosteviol

Catalog No: CFN90544
CAS No: 27975-19-5
Price: $40/20mg

Dictamnine

Catalog No: CFN99783
CAS No: 484-29-7
Price: $40/20mg

Asperuloside

Catalog No: CFN99467
CAS No: 14259-45-1
Price: $118/20mg

Honokiol

Catalog No: CFN99902
CAS No: 35354-74-6
Price: $30/20mg

5'-Guanylic acid

Catalog No: CFN91721
CAS No: 85-32-5
Price: $30/20mg

Homoplantaginin

Catalog No: CFN90344
CAS No: 17680-84-1
Price: $138/20mg

Hotrienol

Catalog No: CFN99583
CAS No: 20053-88-7
Price: $ / mg

beta-Amyrin

Catalog No: CFN98935
CAS No: 559-70-6
Price: $ /

Description:

Alopecurone A exhibits potent inhibitory activity on MRP1.Alopecurone A exhibits cytotoxic activity in DU145 (prostate cancer cell line) and MCF-7 (breast cancer cell line) cell lines with IC50 values of 2.44 and 5.44 μg/mL. respectively.Alopecurone A has antibacterial activity against methicillin-resistant Staphylococcus aureus.

In vitro:

Nat Prod Res. 2014;28(23):2195-2198.

Flavonostilbenes from Sophora alopecuroides L. as multidrug resistance associated protein 1 (MRP1) inhibitors[Pubmed: 24956120]

Flavonoids have always attracted much attention due to their reversal activity on multidrug resistance (MDR). Eight flavonoids isolated from traditional Chinese medicine Sophora alopecuroides L. were applied to test their effect on MDR associated protein 1 (MRP1) through the established predicting assay. Three flavonostilbenes (Alopecurone A, B and D) were first found exhibiting potent inhibitory activity on MRP1. All of them dramatically increased 6-carboxyfluorescein diacetate and doxorubicin accumulation in MRP1-transfected U-2 OS cells. The compounds significantly increased the cytotoxicity and decreased the IC₅₀ value of doxorubicin on the MDR cells (12-, 5- and 8-fold, respectively) at a non-toxic concentration (20 μM). Besides, Q-PCR analysis reveals that the MRP1 mRNA level in U-2 OS/MRP1 was also markedly decreased by the three compounds. These findings indicate a new therapeutic role of the herb. The three flavonostilbenes may have the possibility for further development as novel therapeutic reversal agents against MDR.

Lett Appl Microbiol. 1995 Oct;21(4):219-222.

Antibacterial activity of flavanostilbenes against methicillin-resistant Staphylococcus aureus[Pubmed: 7576511]

Three phytochemical compounds (Alopecurone A-C), flavanostilbenes which are produced by condensation between a hydroxyflavanone and a hydroxystilbene, were isolated as major components from the root of Sophora alopecuroides. They uniformly inhibited the growth of 21 strains of methicillin-resistant Staphylococcus aureus with minimum inhibitory concentrations of 3.13-6.25 micrograms ml-1.

Alopecurone A Description

Source:	The herbs of Sophora alopecuroides
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Cell Research:

Nat Prod Res . 2017 Jun;31(11):1270-1276.

Dereplication of cytotoxic compounds from different parts of Sophora pachycarpa using an integrated method of HPLC, LC-MS and 1 H-NMR techniques[Pubmed: 27696895]

Sophora pachycarpa Schrenk ex C.A.Mey. is an annual plant belonging to the family Fabaceae. The cytotoxic activities of methanol-dichloromethane extracts (1:1) of different parts of S. pachycarpa were investigated on DU145 (prostate cancer cell line) and MCF-7 (breast cancer cell line) cell lines. The root extract of S. pachycarpa was the only extract that showed significant cytotoxic activity with IC50 values of 39.88 and 16.49 μg/mL on DU145 and MCF-7 cell lines, respectively. The root extract was then subjected to RP-HPLC for further fractionations. Among the isolated fractions from root extract, only one of them had remarkable cytotoxic effects with IC50 value of 26.43 on MCF-7 and 7.54 μg/mL on DU145 cell lines. Further purification led to isolation of a compound with IC50 values of 5.44 and 2.44 μg/mL on MCF-7 and DU145 cell lines, respectively. Based on 1H NMR and 13C NMR spectra, together with LC-MS, the structure of the purified compound was assigned as the flavonostilbene Alopecurone A.

Product Name	Alopecurone A
Price:	$318 / 10mg
CAS No.:	162558-89-6
Catalog No.:	CFN95512
Molecular Formula:	C₃₉H₃₈O₉
Molecular Weight:	650.7 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The herbs of Sophora alopecuroides
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Flavonoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.5368 mL	7.684 mL	15.3681 mL	30.7361 mL	38.4202 mL
5 mM	0.3074 mL	1.5368 mL	3.0736 mL	6.1472 mL	7.684 mL
10 mM	0.1537 mL	0.7684 mL	1.5368 mL	3.0736 mL	3.842 mL
50 mM	0.0307 mL	0.1537 mL	0.3074 mL	0.6147 mL	0.7684 mL
100 mM	0.0154 mL	0.0768 mL	0.1537 mL	0.3074 mL	0.3842 mL

CFN92005	Sophoraflavanone G	97938-30-2	424.5	C₂₅H₂₈O₆
CFN93051	Kushenol F	34981-24-3	424.5	C₂₅H₂₈O₆
CFN92003	Kurarinone	34981-26-5	438.5	C₂₆H₃₀O₆
CFN92533	Kurarinol	855746-98-4	456.5	C₂₆H₃₂O₇
CFN97560	Leachianone A	97938-31-3	438.5	C₂₆H₃₀O₆
CFN92004	2'-Methoxykurarinone	270249-38-2	452.6	C₂₇H₃₂O₆
CFN92348	Kushenol B	99217-64-8	492.6	C₃₀H₃₆O₆
CFN96552	Sophoraflavanone I	136997-69-8	650.72	C₃₉H₃₈O₉
CFN96553	Sophoraflavanone H	136997-68-7	582.60	C₃₄H₃₀O₉
CFN95512	Alopecurone A	162558-89-6	650.7	C₃₉H₃₈O₉