Structure Identification: |
Phytochem. Lett., 2013, 6(4):614-9. | α-Glucosidase inhibitory constituents from Chrozophora plicata[Reference: WebLink] | METHODS AND RESULTS: Five new secondary metabolites have been isolated from Chrozophora plicata including an acacetin derivative (1), three pyrrole alkaloids plicatanins A–C (2-4 resp) and the bilactone plicatanone (5). Together with these compounds, the known compounds, β-sitosterol (6), methyl p-coumarate (7), 4-hydroxyphenylacetic acid (8), succinic acid (9), speranberculatine A (10), β-sitosterol-3-O-β- d -glucopyranoside (11) and a Apigenin 5-O-beta-D-glucopyranoside (12) have also been isolated. The structures of isolates 1-12 were established by 1D (1 H,13 C) and 2D NMR (HMQC, HMBC, COSY) spectroscopy and mass spectrometry (EIMS, HREIMS, FABMS, HRFABMS). The structure of plicatanin A (3) was further confirmed through single crystal X-ray technique. Compounds 1-12 were evaluated for their inhibitory activity against the enzyme yeast α -glucosidase.
CONCLUSIONS:
The compound 4 was found to be most potent with IC 50 value 27.802uM. |
|