Apparicine | CAS:2122-36-3 | Manufacturer ChemFaces

Apparicine

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Standard reference

In vitro:

Malar J. 2014 Apr 14;13:142.

Anti-malarial activity of indole alkaloids isolated from Aspidosperma olivaceum.[Pubmed: 24731256 ]

Several species of Aspidosperma (Apocynaceae) are used as treatments for human diseases in the tropics.
METHODS AND RESULTS:
Aspidosperma olivaceum, which is used to treat fevers in some regions of Brazil, contains the monoterpenoid indole alkaloids (MIAs) aspidoscarpine, uleine, Apparicine, and N-methyl-tetrahydrolivacine. Using bio-guided fractionation and cytotoxicity testing in a human hepatoma cell line, several plant fractions and compounds purified from the bark and leaves of the plant were characterized for specific therapeutic activity (and selectivity index, SI) in vitro against the blood forms of Plasmodium falciparum.

Apparicine Description

Source:	The herbs of Voacanga africana
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

J Org Chem. 2014 Jul 3;79(13):6389-93.

Convergent approach to the tetracyclic core of the apparicine class of indole alkaloids via a key intermolecular nitrosoalkene conjugate addition.[Pubmed: 24927230]

METHODS AND RESULTS:
Readily available methyl 3-formylindol-2-ylacetate and N-tosyl-4-chloro-3-piperidone oxime have been used to construct the tetracyclic skeleton of the Apparicine class of monoterpene indole alkaloids in only four steps in 80% overall yield.
CONCLUSIONS:
Key transformations in this convergent approach involve use of an intermolecular ester enolate/nitrosoalkene conjugate addition to form the C-15/16 bond, followed by a reductive cyclization to construct the C-ring of the tetracycle.

J Org Chem. 2009 Nov 6;74(21):8359-68.

Total synthesis of the bridged indole alkaloid apparicine.[Pubmed: 19824689]

METHODS AND RESULTS:
An indole-templated ring-closing metathesis or a 2-indolylacyl radical cyclization constitute the central steps of two alternative approaches developed to assemble the tricyclic ABC substructure of the indole alkaloid Apparicine. From this key intermediate, an intramolecular vinyl halide Heck reaction accomplished the closure of the strained 1-azabicyclo[4.2.2]decane framework of the alkaloid with concomitant incorporation of the exocyclic alkylidene substituents.

Product Name	Apparicine
Price:
CAS No.:	2122-36-3
Catalog No.:	CFN96107
Molecular Formula:	C₁₈H₂₀N₂
Molecular Weight:	264.4 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Oil
Source:	The herbs of Voacanga africana
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.7821 mL	18.9107 mL	37.8215 mL	75.643 mL	94.5537 mL
5 mM	0.7564 mL	3.7821 mL	7.5643 mL	15.1286 mL	18.9107 mL
10 mM	0.3782 mL	1.8911 mL	3.7821 mL	7.5643 mL	9.4554 mL
50 mM	0.0756 mL	0.3782 mL	0.7564 mL	1.5129 mL	1.8911 mL
100 mM	0.0378 mL	0.1891 mL	0.3782 mL	0.7564 mL	0.9455 mL

CFN97329	Ibogaine	83-74-9	310.4	C₂₀H₂₆N₂O
CFN96649	Tabernanthine	83-94-3	310.44	C₂₀H₂₆N₂O
CFN92252	Voacangine	510-22-5	368.5	C₂₂H₂₈N₂O₃
CFN96068	Conopharyngine	76-98-2	398.5	C₂₃H₃₀N₂O₄
CFN96069	19(S)-Hydroxyconopharyngine	16790-93-5	414.5	C₂₃H₃₀N₂O₅
CFN96176	Crassanine	16790-92-4	414.5	C₂₃H₃₀N₂O₅
CFN99765	Catharanthine	2468-21-5	336.43	C₂₁H₂₄N₂O₂
CFN90318	Catharanthine Tartrate	2648-21-5	486.40	C₂₁H₂₄N₂O₂.C₄H₆O₆
CFN93298	Catharanthine Sulfate	70674-90-7	434.51	C₂₁H₂₆N₂O₆S
CFN98432	19,20-(E)-Vallesamine	3368-87-4	340.4	C₂₀H₂₄N₂O₃