Atropine sulfate monohydrate | CAS:5908-99-6

Atropine sulfate monohydrate

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Description:

Atropine sulfate monohydrate has anticholinergic activity.Atropine sulfate monohydrate can inhibit dose-dependently spontaneous bladder contractions caused by raising the intravesical volume in conscious rats.

In vivo:

Arzneimittel-Forschung, 1994, 44(11):1242-9.

Urinary bladder-selective action of the new antimuscarinic compound vamicamide.[Reference: WebLink]

METHODS AND RESULTS:
1. The inhibitory action of vamicamide (FK176, (+/-)-(2R*,4R*)-4-dimethylamino-2-phenyl-2-(2-pyridyl)valeramide, CAS 132373-81-0) on the responses of various tissues to the cholinergic agonists, carbachol and McN-A-343 (4-[m-chlorophenylcarbamoyloxy]-2-butynyl-trimethylammonium chloride, CAS 55-45-8), was investigated in isolated tissue preparations. Vamicamide showed competitive antagonistic actions against all the preparations tested and its pA2 value for the urinary bladder was 6.82, which was higher than that for the atria (5.94) and almost the same as that for the vas deferens (6.90) and for the stomach (6.81). The pA2 values of oxybutynin hydrochloride (oxybutynin) and Atropine sulfate monohydrate (atropine) were nearly the same in all the tissues tested. 2. Oral administration of vamicamide 0.1-1.0 mg/kg inhibited dose-dependently spontaneous bladder contractions caused by raising the intravesical volume in conscious rats. Inhibitory actions were also obtained with 0.32-3.2 mg/kg of oxybutynin or 0.0032-0.032 mg/kg of atropine, but the duration of action of oxybutynin was shorter than that of vamicamide or atropine. Vamicamide further inhibited bladder contractions in rats following intravesical administration of 0.05-0.5 mg/ml solution. 3. Vamicamide had no effect or only slightly inhibited spontaneous motility of the stomach and distal colon in conscious rats, as well as heart rate and salivary secretion in conscious dogs, after oral dosing with 3.2 mg/kg of the compound.
CONCLUSIONS:
Similar results were obtained with oxybutynin, excepting the occurrence of tachycardia.

Atropine sulfate monohydrate Description

Source:	The seeds of Datura metelL
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Turkish Journal of Chemistry, 2014, 38(3):477-487.

Spectroscopic investigation and oxidation of the anticholinergic drug atropine sulfate monohydrate by hexacyanoferrate(III) in aqueous alkaline media: a mechanistic approach.[Reference: WebLink]

METHODS AND RESULTS:
The oxidation of the anticholinergic drug Atropine sulfate monohydrate by hexacyanoferrate(III) in aqueous alkaline media was investigated spectrophotometrically by monitoring the decrease in absorbance of hexacyanoferrate(III) (HCF(III)). Oxidation products were identified. The oxidation mechanism was proposed from kinetic studies. The reaction constants involved in the different steps of the mechanism were calculated. The effects of added products, ionic strength, and dielectric constant of the reaction were investigated.
CONCLUSIONS:
The polymerization test revealed that oxidation occurred with intervention of free radicals. The activation parameters were evaluated.

Product Name	Atropine sulfate monohydrate
Price:	$30 / 20mg
CAS No.:	5908-99-6
Catalog No.:	CFN70157
Molecular Formula:	C₁₇H₂₇NO₈S
Molecular Weight:	405.5 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The seeds of Datura metelL
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.4661 mL	12.3305 mL	24.6609 mL	49.3218 mL	61.6523 mL
5 mM	0.4932 mL	2.4661 mL	4.9322 mL	9.8644 mL	12.3305 mL
10 mM	0.2466 mL	1.233 mL	2.4661 mL	4.9322 mL	6.1652 mL
50 mM	0.0493 mL	0.2466 mL	0.4932 mL	0.9864 mL	1.233 mL
100 mM	0.0247 mL	0.1233 mL	0.2466 mL	0.4932 mL	0.6165 mL

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CFN90020	Roflumilast	162401-32-3	403.21	C₁₇H₁₄Cl₂F₂N₂O₃
CFN96783	Psiguadial D	1402066-95-8	474.59	C₃₀H₃₄O₅
CFN98610	Totaradiol	3772-56-3	302.5	C₂₀H₃₀O₂