Bacosine | CAS:198014-94-7 | Manufacturer ChemFaces

Bacosine

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Description:

Bacosine exhibits moderate analgesic effects, it also plays a role in regulating cell metastasis by inhibiting MMP-9 and showing anti-apoptotic effect in breast cancer cells. Bacosine may have insulin-like activity and its antihyperglycemic effect might be due to an increase in peripheral glucose consumption as well as protection against oxidative damage in alloxanized diabetes.

Targets:

MMP | SOD | GSH

In vitro:

Fitoterapia, 1997, 68(4):361-365.

Analgesic activity of bacosine, a new triterpene isolated from Bacopa monnieri.[Reference: WebLink]

METHODS AND RESULTS:
Bacosine (1) isolated from the aerial parts of Bacopa monnieri, exhibited moderate analgesic effects but was found to be devoid of effects on barbiturate narcosis, haloperidol-induced catalepsy, spontaneous motor activity (SMA) and conditioned avoidance response (CAR).
CONCLUSIONS:
The analgesic effects, reported for the first time in this plant, were found to be opioidergic in nature.

Proceedings of the National Academy of Sciences India, 2018, 89(8):1-5.

In Vitro Analysis of Bacosine as Novel Therapeutic Agent for Murine Breast Cancer.[Reference: WebLink]

METHODS AND RESULTS:
The anti-metastatic activity of Bacosine (Bacopa monnieri plant) was studied using 4T1 murine breast cancer cell line by targeting matrix metalloproteinases (MMPs) which plays important role in invasion and metastasis. The inhibitory concentration (IC50) of Bacosine for 4T1 cell line was 21 μM, which indicates that it is toxic to cancer cell line. The effect of different concentrations (10, 21 and 50 μM) of Bacosine on metastatic matrix metalloproteinase-9 (MMP-9) gene expression of 4T1 murine breast cancer cells was studied by real time PCR. At high concentrations of Bacosine (21 and 50 μM) MMP-9 gene expression was down-regulated after 24 h of treatment in a concentration dependent manner. The effect of Bacosine on apoptosis was evaluated by annexin binding assay which showed anti-apoptotic effect in early and late apoptotic stages of cancer cells.
CONCLUSIONS:
These results suggest that Bacosine plays a role in regulating cell metastasis by inhibiting MMP-9 and showing anti-apoptotic effect in breast cancer cells.

Bacosine Description

Source:	The herbs of Bacopa monnieri
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Animal Research:

Planta Medica, 10 Dec 2010, 77(8):804-808

Antihyperglycemic activity of bacosine, a triterpene from Bacopa monnieri, in alloxan-induced diabetic rats.[Reference: WebLink]

This article describes the antihyperglycemic activity, in vivo antioxidant potential, effect on hemoglobin glycosylation, estimation of liver glycogen content, and in vitro peripheral glucose utilization of Bacosine, a triterpene isolated from the ethyl acetate fraction (EAF) of the ethanolic extract of Bacopa monnieri.
METHODS AND RESULTS:
Bacosine produced a significant decrease in the blood glucose level when compared with the diabetic control rats both in the single administration as well as in the multiple administration study. It was observed that the compound reversed the weight loss of the diabetic rats, returning the values to near normal. Bacosine also prevented elevation of glycosylated hemoglobin in vitro with an IC₅₀ value of 7.44 µg/mL, comparable with the one for the reference drug α-tocopherol. Administration of Bacosine and glibenclamide significantly decreased the levels of malondialdehyde (MDA), and increased the levels of reduced glutathione (GSH) and the activities of superoxide dismutase (SOD) and catalase (CAT) in the liver of diabetic rats. Bacosine increased glycogen content in the liver of diabetic rats and peripheral glucose utilization in the diaphragm of diabetic rats in vitro, which is comparable with the action of insulin.
CONCLUSIONS:
Thus, Bacosine might have insulin-like activity and its antihyperglycemic effect might be due to an increase in peripheral glucose consumption as well as protection against oxidative damage in alloxanized diabetes.

Product Name	Bacosine
Price:
CAS No.:	198014-94-7
Catalog No.:	CFN70298
Molecular Formula:	C₃₀H₄₈O₃
Molecular Weight:	456.7 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The herbs of Bacopa monnieri
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Triterpenoids Compound Library SOD Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1896 mL	10.9481 mL	21.8962 mL	43.7924 mL	54.7405 mL
5 mM	0.4379 mL	2.1896 mL	4.3792 mL	8.7585 mL	10.9481 mL
10 mM	0.219 mL	1.0948 mL	2.1896 mL	4.3792 mL	5.4741 mL
50 mM	0.0438 mL	0.219 mL	0.4379 mL	0.8758 mL	1.0948 mL
100 mM	0.0219 mL	0.1095 mL	0.219 mL	0.4379 mL	0.5474 mL

CFN89222	3alpha-Acetoxy-20(29)-lupene-23,28-dioic acid	83725-41-1	528.73	C₃₂H₄₈O₆
CFN96223	Acantrifoic acid A	654663-85-1	544.7	C₃₂H₄₈O₇
CFN70298	Bacosine	198014-94-7	456.7	C₃₀H₄₈O₃
CFN99759	Betulinaldehyde	13159-28-9	440.70	C₃₀H₄₈O₂
CFN98706	Betulinic acid	472-15-1	456.7	C₃₀H₄₈O₃
CFN91073	Betulinic acid methyl ester	2259-06-5	470.7	C₃₁H₅₀O₃
CFN89164	Pyracrenic acid	80832-44-6	618.85	C₃₉H₅₄O₆
CFN90772	Cussosaponin C	366814-42-8	1204	C₅₉H₉₆O₂₅
CFN98682	Betulonic acid	4481-62-3	454.7	C₃₀H₄₆O₃
CFN97504	20-Hydroxy-3-oxo-28-lupanoic acid	93372-87-3	472.7	C₃₀H₄₈O₄