| Structure Identification: |
| J Sep Sci. 2017 May;40(9):1906-19. | | Flexible and powerful strategy for qualitative and quantitative analysis of valepotriates in Valeriana jatamansi Jones using high-performance liquid chromatography with linear ion trap Orbitrap mass spectrometry.[Pubmed: 28296152 ] |
Valeriana jatamansi Jones is an important medicinal plant and its quality is closely related to its region of origin. In the current study, we utilized a flexible and powerful strategy for comprehensive evaluation of the quality diversity for 15 regions in China.
METHODS AND RESULTS:
The method was based on a hybrid linear ion trap-Orbitrap mass spectrometry platform. For structure characterization, fragmentation patterns were detected by analyzing a series of standard compounds using data dependent multistage mass spectrometry acquisition. A fragment ion database for valepotriates was established, and the acquired data were high throughput filtered by fragment ion search for compound identification. For quantitative purposes, we normalized the mass spectrometry data of 15 samples using SIEVE 2.0 and the differences in composition were analyzed using principal component analysis combined with hierarchical clustering analysis. The results identified a total of 92 compounds from Valeriana jatamansi Jones. Samples from Dali, Kunming, and Baoshan have better qualities and concentrations of the main active constituents.
To verify our strategy, we compared the valtrate, acevaltrate, and Baldrinal contents using high-performance liquid chromatography with diode array detector.
CONCLUSIONS:
We developed and validated a comprehensive qualitative and quantitative analytical method to achieve quality control of Valeriana jatamansi Jones. | | Arch Pharm Res. 2005 Oct;28(10):1161-3. | | 11-Methoxyviburtinal, a new iridoid from Valeriana jatamansi.[Pubmed: 16276973] |
METHODS AND RESULTS:
Five compounds of iridoids, lignan and phenylpropanoid glycosides were isolated from the roots of Valeriana jatamansi by column chromatography. Their structures were elucidated as 11-methoxyviburtinal (1), Baldrinal (2), prinsepiol-4-omicron-beta-D-glucoside (3), coniferin (4), and hexacosanic acid (5) by spectroscopic analysis.
CONCLUSIONS:
11-Methoxyviburtinal was a new compound, and others were isolated from the plant for the first time. |
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