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Barpisoflavone A
Barpisoflavone A
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Barpisoflavone A
Price:
CAS No.: 101691-27-4
Catalog No.: CFN97861
Molecular Formula: C16H12O6
Molecular Weight: 300.27 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Yellow powder
Source: The herbs of Crotalaria pallida
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
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10 mM * 1 mL in DMSO / Inquiry / In-stock
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Biological Activity
Description: Barpisoflavone A possesses moderate estrogen partial agonistic activities and moderate antioxidant activities.
Targets: Estrogen receptor | Progestogen receptor
In vitro:
Biosci Biotechnol Biochem. 2016;80(4):774-8.
Biological activities of unique isoflavones prepared from Apios americana Medik.[Pubmed: 26806328]

METHODS AND RESULTS:
Four unique isoflavone aglycones (Barpisoflavone A (1), 2'-hydroxygenistein (2), 5-methylgenistein (3), and gerontoisoflavone A (4)) whose structures were related to genistein were prepared from the tuber of Apios americana Medik. We examined the estrogen receptor and androgen receptor binding activities, estrogen agonistic activities, antioxidant activities, and α-glucosidase inhibitory activities of 1-4.
CONCLUSIONS:
The results obtained showed that 2 possessed potent and 1, 3, and 4 possessed moderate estrogen partial agonistic activities, 1 and 2 possessed moderate antioxidant activities, and 2 and 3 possessed moderate α-glucosidase inhibitory activities.
Barpisoflavone A Description
Source: The herbs of Crotalaria pallida
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.3303 mL 16.6517 mL 33.3034 mL 66.6067 mL 83.2584 mL
5 mM 0.6661 mL 3.3303 mL 6.6607 mL 13.3213 mL 16.6517 mL
10 mM 0.333 mL 1.6652 mL 3.3303 mL 6.6607 mL 8.3258 mL
50 mM 0.0666 mL 0.333 mL 0.6661 mL 1.3321 mL 1.6652 mL
100 mM 0.0333 mL 0.1665 mL 0.333 mL 0.6661 mL 0.8326 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Agricultural and biological chemistry.1986 July23;50(7):1809-1819.
New 5-O-Methylisoflavones in the Roots of Yellow Lupin : Lupinus luteus L. cv. Barpine(Organic Chemistry).[Reference: WebLink]

METHODS AND RESULTS:
In addition to 5-O-methylgenistein (1), a further investigation of the isoflavonoid constituents in roots of the yellow lupin (Lupinus luteus L. cv. Barpine) has yielded five new 5-O-methylisoflavones named Barpisoflavone A (2), 5-O-methyl-lupiwighteone (3), barpisoflavone B (4), 5-O-methylderrone (5) and barpisoflavone C (6).
CONCLUSIONS:
These isoflavones were identified by physicochemical methods involving the use of other lupin isoflavones as reference compounds.
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