Bohemamine | CAS:72926-12-6 | Manufacturer ChemFaces

Bohemamine

ChemFaces products have been cited in many studies from excellent and top scientific journals

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Bohemamine is a cell adhesion inhibitor, it inhibits adhesion of HL-60 cells to CHO-ICAM-1 cells at IC50 values of 27.2 microg/ml.

In vitro:

Genome Announc. 2015 Feb 19;3(1).

Draft Genome Sequence of Marine-Derived Streptomyces sp. TP-A0873, a Producer of a Pyrrolizidine Alkaloid Bohemamine.[Pubmed: 25700394]

METHODS AND RESULTS:
Streptomyces sp. TP-A0873, isolated from deep-sea water, produces three different classes of secondary metabolites: antimycin, Bohemamine, and alkylated butenolides. In order to assess the biosynthetic potential of this strain, draft genome sequencing was carried out.
CONCLUSIONS:
The genome contained at least 14 gene clusters for polyketide synthase (PKS) and nonribosomal peptide synthetase (NRPS).

J Antibiot (Tokyo). 2003 Aug;56(8):673-81.

New cell-cell adhesion inhibitors from Streptomyces sp. UMA-044.[Pubmed: 14563155]

METHODS AND RESULTS:
Three compounds, NP25301 (1), NP25302 (2) and Bohemamine (3), inhibitors of cell adhesion based on LFA-1/ICAM-1, were isolated from the cultured broth of the strain Streptomyces sp. UMA-044. New compounds 1 and 2 were identified as 2-(3'-carbamoylphenoxy)acrylic acid methyl ester and deoxyBohemamine, respectively, based on spectroscopic analyses.
CONCLUSIONS:
Compounds 1 approximately 3 inhibited adhesion of HL-60 cells to CHO-ICAM-1 cells at IC50 values of 29.5 microg/ml for 1, 24.3 microg/ml for 2, and 27.2 microg/ml for 3.

Bohemamine Description

Source:	From Actinosporangium sp.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Bohemamine
Price:
CAS No.:	72926-12-6
Catalog No.:	CFN00245
Molecular Formula:	C₁₄H₁₈N₂O₃
Molecular Weight:	262.30 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Oil
Source:	From Actinosporangium sp.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.8124 mL	19.0621 mL	38.1243 mL	76.2486 mL	95.3107 mL
5 mM	0.7625 mL	3.8124 mL	7.6249 mL	15.2497 mL	19.0621 mL
10 mM	0.3812 mL	1.9062 mL	3.8124 mL	7.6249 mL	9.5311 mL
50 mM	0.0762 mL	0.3812 mL	0.7625 mL	1.525 mL	1.9062 mL
100 mM	0.0381 mL	0.1906 mL	0.3812 mL	0.7625 mL	0.9531 mL

CFN00236	Amabiline	17958-43-9	283.37	C₁₅H₂₅NO₄
CFN00237	Cynaustine	17958-39-3	283.37	C₁₅H₂₅NO₄
CFN00238	Supinine	551-58-6	283.37	C₁₅H₂₅NO₄
CFN00239	Heleurine	488-00-6	297.39	C₁₆H₂₇NO₄
CFN00240	Absouline	112513-33-4	286.37	C₁₇H₂₂N₂O₂
CFN00241	Isoabsouline	112513-34-5	286.37	C₁₇H₂₂N₂O₂
CFN00242	Anchustrigosine	N/A	471.59	C₂₄H₄₁NO₈
CFN00244	Assamicadine	126260-96-6	309.36	C₁₆H₂₃NO₅
CFN00245	Bohemamine	72926-12-6	262.30	C₁₄H₁₈N₂O₃
CFN00246	Callimorphine	74991-73-4	297.35	C₁₅H₂₃NO₅