Bruceine E | CAS:21586-90-3 | Manufacturer ChemFaces

Bruceine E

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Description:

Bruceine E exhibits significant blood glucose concentration reduction activity, it might act as an insulin secretagogue.

In vitro:

Arch Pharm Res. 2011 Aug;34(8):1297-300.

One new pregnane glycoside from the seeds of cultivated Brucea javanica.[Pubmed: 21910051]

A new pregnane glycoside, named (20R)-O-(3)-β-D-glucopyranosyl-(1→2)-α-L-arabinopyranosyl-pregn-5-en-3β,20-diol (1), and seven known compounds, brusatol (2), bruceine B (3), bruceine D (4), yadanziolide A (5), Bruceine E (6), yadanzioside G (7), and yadanzioside B (8), were isolated from the cultivated dry seeds of Brucea javanica.
METHODS AND RESULTS:
The structure of 1 was elucidated on the basis of 1D- and 2D-NMR spectroscopic analyses. Their inhibitory effects on tumor cells were also tested. Compound 1 was slightly active against HL-60, SMMC-7721, A-549, and MCF-7 tumor cells. Compounds 2 and 3 demonstrated significant inhibitory activities against all tested cells.
CONCLUSIONS:
These results indicate that cultivated B. javanica could replace the wild plant as an antitumor plant resource.

In vivo:

J Ethnopharmacol. 2009 Jul 30;124(3):586-91.

Hypoglycemic effect of quassinoids from Brucea javanica (L.) Merr (Simaroubaceae) seeds.[Pubmed: 19439174 ]

The seeds of Brucea javanica (L.) Merr (Simaroubaceae) are recommended by traditional practitioners for the treatment of diabetes mellitus. To identify the compounds responsible for blood glucose lowering effect and evaluate the acute toxicity of the compounds.
METHODS AND RESULTS:
Extracts, fractions and subfractions were administered to normoglycemic mice and the blood glucose concentration was monitored for 8 h. Bioactive compounds isolated through column chromatography were administered to normoglycemic mice and streptozotocin (STZ) rats with monitoring of blood glucose concentration at 0-8h. The acute toxicity was evaluated in mice. Bioactivity-guided fractionation led to the isolation of Bruceine E (1) and bruceine D (2). Normoglycemic mice administered with 1 mg/kg of 1 and 2 exhibited significant blood glucose concentration reduction of 40.07+/-11.45% and 48.82+/-13.34%, respectively. STZ induced diabetic rats administered with 1 and 2 exhibited significant blood glucose concentration reduction of 73.57+/-13.64% and 87.99+/-2.91%, respectively.
CONCLUSIONS:
The reduction of blood glucose concentration by both bruceines was comparable to glibenclamide and they might act as an insulin secretagogue. The presence of a hydroxyl moiety at C(2) in 1 reduced the toxic effect by 9-fold compared to 2.

Bruceine E Description

Source:	The seeds of Brucea javanica (L.) Merr.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Bruceine E
Price:	$138 / 20mg
CAS No.:	21586-90-3
Catalog No.:	CFN89340
Molecular Formula:	C₂₀H₂₈O₉
Molecular Weight:	412.43 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The seeds of Brucea javanica (L.) Merr.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antihyperglycemic Compound Library Insulin-stimulated action Compound Library Diterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.4247 mL	12.1233 mL	24.2465 mL	48.4931 mL	60.6163 mL
5 mM	0.4849 mL	2.4247 mL	4.8493 mL	9.6986 mL	12.1233 mL
10 mM	0.2425 mL	1.2123 mL	2.4247 mL	4.8493 mL	6.0616 mL
50 mM	0.0485 mL	0.2425 mL	0.4849 mL	0.9699 mL	1.2123 mL
100 mM	0.0242 mL	0.1212 mL	0.2425 mL	0.4849 mL	0.6062 mL

CFN96420	Yadanzioside K	101559-98-2	768.76	C₃₆H₄₈O₁₈
CFN92980	13,18-Dehydroglaucarubinone	68703-94-6	492.52	C₂₅H₃₂O₁₀
CFN92979	(+)-Glaucarubinone	1259-86-5	494.53	C₂₅H₃₄O₁₀
CFN89335	Bruceine B	25514-29-8	480.46	C₂₃H₂₈O₁₁
CFN91974	Bruceine C	25514-30-1	564.58	C₂₈H₃₆O₁₂
CFN89336	Bruceantinol	53729-52-5	606.62	C₃₀H₃₈O₁₃
CFN95216	Bruceantinol B	1822332-33-1	550.6	C₂₇H₃₄O₁₂
CFN91971	Bruceantinol A	948038-36-6	592.59	C₂₉H₃₆O₁₃
CFN91973	Bruceine J	948038-38-8	508.51	C₂₅H₃₂O₁₁
CFN89338	Bruceine A	25514-31-2	522.54	C₂₆H₃₄O₁₁