Science | Nature | Cell | View More
Natural Products
Butyric acid
Butyric acid
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Butyric acid
Price: $30 / 20mg
CAS No.: 107-92-6
Catalog No.: CFN70017
Molecular Formula: C4H8O2
Molecular Weight: 88.1 g/mol
Purity: >=98%
Type of Compound: Miscellaneous
Physical Desc.: Oil
Source:
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • The Vancouver Prostate Centre (... (Canada)
  • Center for protein Engineering ... (Belgium)
  • Universiti Sains Malaysia (Malaysia)
  • Rio de Janeiro State University (Brazil)
  • Technical University of Denmark (Denmark)
  • Charles University in Prague (Czech Republic)
  • Mahidol University (Thailand)
  • Universidad de Ciencias y Artes... (Mexico)
  • University of Wuerzburg (Germany)
  • University of British Columbia (Canada)
  • Massachusetts General Hospital (USA)
  • More...
Package
Featured Products
Croceic acid

Catalog No: CFN90226
CAS No: 27876-94-4
Price: $60/20mg
(-)-Hinokinin

Catalog No: CFN92255
CAS No: 26543-89-5
Price: $ / mg
Iridin

Catalog No: CFN96557
CAS No: 491-74-7
Price: $50/20mg
Brusatol

Catalog No: CFN93119
CAS No: 14907-98-3
Price: $168/20mg
Vanillin

Catalog No: CFN90463
CAS No: 121-33-5
Price: $30/20mg
Rhodionin

Catalog No: CFN99758
CAS No: 85571-15-9
Price: $258/10mg
Sakakin

Catalog No: CFN98059
CAS No: 21082-33-7
Price: $40/20mg
Aloin B

Catalog No: CFN90434
CAS No: 28371-16-6
Price: $138/20mg
Asperuloside

Catalog No: CFN99467
CAS No: 14259-45-1
Price: $118/20mg
Shikonin

Catalog No: CFN99907
CAS No: 517-88-4
Price: $50/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Butyric acid, a potent inducer of erythroid differentiation in cultured erythroleukemic cells, it induces apoptosis in human hepatic tumour cells. Butyric acid causes morphological changes in cultured chondrocytes through alterations in the extracellular matrix.
Targets: cAMP
In vitro:
Cell, 1975, 5(3):319-322.
Butyric acid, a potent inducer of erythroid differentiation in cultured erythroleukemic cells.[Pubmed: 1056809]
Butyric acid is an unusually potent inducer of erythroid differentiation in cultured erythroleukemic cells. It is effective at one hundredth the concentration required of dimethylsulfoxide, a most effective inducing agent.
METHODS AND RESULTS:
Studies using a variety of analogues and metabolites suggest that the structural features of Butyric acid are rather stringently required for induction. This effect is considered in view of the fact that Butyric acid is a naturally occurring fatty acid, is effective in relatively low concentrations, and is widely used to form derivatives of cAMP.
Butyric acid Description
Source:
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Secologanic acid

Catalog No: CFN95028
CAS No: 60077-46-5
Price: $418/20mg
3',8-Dihydroxyvestitol

Catalog No: CFN95384
CAS No: 122587-87-5
Price: $413/5mg
Isosaponarin 2''-O-glucoside (Isov...

Catalog No: CFN95296
CAS No: 63316-27-8
Price: $318/10mg
3beta-Hydroxyurs-12,18-dien-28-oic...

Catalog No: CFN95461
CAS No: 434942-42-4
Price: $318/5mg
Ganoderenic acid K

Catalog No: CFN95469
CAS No: 942950-94-9
Price: $318/10mg
Euphorbia factor L22

Catalog No: CFN95338
CAS No: 1613700-09-6
Price: $413/5mg
Ganoderic acid J

Catalog No: CFN95516
CAS No: 100440-26-4
Price: $318/10mg
Gambogoic acid A

Catalog No: CFN95439
CAS No: 887923-49-1
Price: $318/10mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 11.3507 mL 56.7537 mL 113.5074 mL 227.0148 mL 283.7684 mL
5 mM 2.2701 mL 11.3507 mL 22.7015 mL 45.403 mL 56.7537 mL
10 mM 1.1351 mL 5.6754 mL 11.3507 mL 22.7015 mL 28.3768 mL
50 mM 0.227 mL 1.1351 mL 2.2701 mL 4.5403 mL 5.6754 mL
100 mM 0.1135 mL 0.5675 mL 1.1351 mL 2.2701 mL 2.8377 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Cell Research:
Journal of Cellular Physiology, 1989, 138(1):197-204.
Butyric acid causes morphological changes in cultured chondrocytes through alterations in the extracellular matrix.[Pubmed: 2910883]
Butyric acid induces characteristic changes in the morphology of chick embryo chondrocytes.
METHODS AND RESULTS:
Chick embryo chondrocytes when cultured in the absence of butyrate exhibit a spherical morphology and synthesize cartilage-specific chondroitin sulfate proteoglycan (CSPG). When these cultures are initiated and maintained in the presence of Butyric acid, chondrocytes exhibit a mesenchymal morphology, a 90% reduction in the synthesis of CSPG, and a 75% reduction in DNA synthesis. The reduced synthesis of CSPG and DNA was shown not to be dependent on the morphological change. Chondrocytes require CSPG in order to express a spherical morphology, since including chondroitinase ABC in the culture media caused the cells to spread. In addition, the treatment of chondrocytes with purified CSPG prior to culture in media containing Butyric acid resulted in spherical cells. The butyrate-induced spreading was shown to require either serum or fibronectin and could be prevented with antiserum against chick cell-surface fibronectin (cFn). Cell-surface fibronectin, which was present on both spherical and flattened chondrocytes, organized into fibrils beneath cells which spread. Increased fibronectin synthesis was not responsible for the butyrate-induced morphological change.
CONCLUSIONS:
From this evidence, it is concluded that the mechanism by which butyrate alters the morphology of these cells in culture involves inhibiting CSPG synthesis, thus preventing CSPG accumulation in the extracellular matrix (ECM). The absence of CSPG in the ECM allows fibronectin to mediate spreading of chondrocytes in culture.
Structure Identification:
Journal of Oleo ence, 1999, 48(4):331-337,364.
Simple Determination of Fatty Acid Compositions of Edible Oils by Lipase Hydrolysis and High-Performance Liquid Chromatography.[Reference: WebLink]

METHODS AND RESULTS:
High-performance liquid chromatography (HPLC) using a 205 nm UV detector was evaluated for usefulness in determining fatty acid compositions, especially unsaturated fatty acid compositions, of edible oils such as perilla, soybean and safflower oils, which mainly consist of triglycerides that contain mono and polyunsaturated fatty acids. Fatty acids were obtained by lipase-hydrolysis followed by petroleum ether extraction. Sample fatty acids were analyzed by HPLC without conversion to the derivatives. Butyric acid served as the internal standard for determination of fatty acids. The results showed close agreement with those of GC.
CONCLUSIONS:
The present method is applicable to the simple determination of fatty acid compositions, especially unsaturated fatty acid compositions, of edible oils without degradation due to heating and/or the oxidative deterioration of unsaturated fatty acids.
Croceic acid

Catalog No: CFN90226
CAS No: 27876-94-4
Price: $60/20mg
(-)-Hinokinin

Catalog No: CFN92255
CAS No: 26543-89-5
Price: $ / mg
Iridin

Catalog No: CFN96557
CAS No: 491-74-7
Price: $50/20mg
Brusatol

Catalog No: CFN93119
CAS No: 14907-98-3
Price: $168/20mg
Vanillin

Catalog No: CFN90463
CAS No: 121-33-5
Price: $30/20mg
Rhodionin

Catalog No: CFN99758
CAS No: 85571-15-9
Price: $258/10mg
Sakakin

Catalog No: CFN98059
CAS No: 21082-33-7
Price: $40/20mg
Aloin B

Catalog No: CFN90434
CAS No: 28371-16-6
Price: $138/20mg
Asperuloside

Catalog No: CFN99467
CAS No: 14259-45-1
Price: $118/20mg
Shikonin

Catalog No: CFN99907
CAS No: 517-88-4
Price: $50/20mg
Tags: buy Butyric acid | Butyric acid supplier | purchase Butyric acid | Butyric acid cost | Butyric acid manufacturer | order Butyric acid | Butyric acid distributor