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L-Citruline
L-Citruline
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name L-Citruline
Price: $30 / 20mg
CAS No.: 372-75-8
Catalog No.: CFN90551
Molecular Formula: C6H13N3O3
Molecular Weight: 175.18 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The herbs of Citrullus lanatus.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $7.0 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: L-citrulline is a substance called a non-essential amino acid that is used as a sports performance and cardiovascular health supplement.
Targets: NO | IL Receptor
In vitro:
Chromatographia . 2018;81(6):911-921.
Quantitative Analysis of l-Arginine, Dimethylated Arginine Derivatives, l-Citrulline, and Dimethylamine in Human Serum Using Liquid Chromatography-Mass Spectrometric Method[Pubmed: 29887621]
Abstract Abstract: Nitric oxide (NO) is a small molecule involved in the regulation of many physiological processes. It plays a crucial role in the regulation of nervous system, immune and inflammatory responses, and blood flow. NO is synthesized by nitric oxide synthase (NOS) during two-step oxidation of l-arginine to l-citrulline. Intermediates and derivatives of NO metabolism, such as l-arginine, l-citrulline, asymmetrical dimethylarginine (ADMA), symmetrical dimethylarginine (SDMA), and dimethylamine (DMA), are investigated as potential biomarkers. In this article, we present a novel analytical method that allowed for simultaneous analysis of l-arginine, ADMA, SDMA, l-citrulline, and DMA, in a single-step extraction and derivatization using benzoyl chloride. In brief, aliquots of serum were mixed with internal standard solution mixture (50 μM D6-DMA, 20 μM D7-ADMA, and 100 μM D7-arginine) and 0.025 M borate buffer, pH 9.2 (10:1:5). The derivatization process was performed at 25 °C for 5 min using 10% benzoyl chloride. A reverse phase column was used for chromatographic separation. Quantitation was performed using following ions (m/z): 279.1457, 286.1749, 307.1717, 314.2076, 280.1297, 150.0919, and 156.1113 for l-arginine, D7-arginine, ADMA, SDMA, D7-ADMA, l-citrulline, DMA, and D6-DMA, respectively. The method was validated, and its assay linearity, accuracy and precision, recovery, and limits of detection (1.7 μM l-arginine, 0.03 μM ADMA, 0.02 μM SDMA, 0.36 μM l-citrulline, 0.06 μM DMA) and quantification (3.2 μM l-arginine, 0.08 μM ADMA, 0.05 μM SDMA, 1.08 μM l-citrulline, 0.19 μM DMA) were determined. The method is sensitive, reliable, repeatable, and reproducible. It can be applied in the routine clinical/diagnostic laboratory. Keywords: Amino acid derivatization; Asymmetric dimethylarginine; Citrulline; Dimethylamine; Liquid
In vivo:
The Journal of Clinical Hypertension Volume 17, Issue 1, pages 14–19, January 2015
Digital Plethysmography and Arginine Metabolism in Prehypertension—Effect of Nebivolol Therapy[Reference: WebLink]
Prehypertension is an important phenotype for cardiovascular risk and development of established hypertension.
METHODS AND RESULTS:
To better understand the early circulatory changes in this group, the authors studied 34 patients with prehypertension (blood pressure 120–139/80–89 mm Hg) using digital plethysmography for measurement of blood flow and reactive hyperemic index (RHI). Arterial augmentation index (AI) was also measured. Because prehypertension is associated with endothelial dysfunction and decreased availability of nitric oxide (NO), indices of arginine metabolism (l-arginine, asymmetric dimethylarginine (ADMA), symmetric dimethylarginine, and L-Citruline) were measured. Nebivolol (5 mg/d), a vasodilating β1-antagonist with β3-agonist activity, was studied in a double-blind fashion for 8 weeks.
Front Immunol. 2013 Dec 24;4:480.
l-Citrulline Protects from Kidney Damage in Type 1 Diabetic Mice.[Pubmed: 24400007]
Diabetic nephropathy (DN) is a major cause of end-stage renal disease, associated with endothelial dysfunction. Chronic supplementation of l-arginine (l-arg), the substrate for endothelial nitric oxide synthase (eNOS), failed to improve vascular function. L-Citruline (l-cit) supplementation not only increases l-arg synthesis, but also inhibits cytosolic arginase I, a competitor of eNOS for the use of l-arg, in the vasculature. To investigate whether l-cit treatment reduces DN in streptozotocin (STZ)-induced type 1 diabetes (T1D) in mice and rats and to study its effects on arginase II (ArgII) function, the main renal isoform.
METHODS AND RESULTS:
STZ-C57BL6 mice received l-cit or vehicle supplemented in the drinking water. For comparative analysis, diabetic ArgII knock out mice and l-cit-treated STZ-rats were evaluated. L-Citruline exerted protective effects in kidneys of STZ-rats, and markedly reduced urinary albumin excretion, tubulo-interstitial fibrosis, and kidney hypertrophy, observed in untreated diabetic mice. Intriguingly, l-cit treatment was accompanied by a sustained elevation of tubular ArgII at 16 weeks and significantly enhanced plasma levels of the anti-inflammatory cytokine IL-10. Diabetic ArgII knock out mice showed greater blood urea nitrogen levels, hypertrophy, and dilated tubules than diabetic wild type (WT) mice. Despite a marked reduction in collagen deposition in ArgII knock out mice, their albuminuria was not significantly different from diabetic WT animals. l-Cit also restored nitric oxide/reactive oxygen species balance and barrier function in high glucose-treated monolayers of human glomerular endothelial cells. Moreover, l-cit also has the ability to establish an anti-inflammatory profile, characterized by increased IL-10 and reduced IL-1β and IL-12(p70) generation in the human proximal tubular cells.
CONCLUSIONS:
L-Citruline supplementation established an anti-inflammatory profile and significantly preserved the nephron function during T1D.
L-Citruline Description
Source: The herbs of Citrullus lanatus.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.7084 mL 28.5421 mL 57.0841 mL 114.1683 mL 142.7104 mL
5 mM 1.1417 mL 5.7084 mL 11.4168 mL 22.8337 mL 28.5421 mL
10 mM 0.5708 mL 2.8542 mL 5.7084 mL 11.4168 mL 14.271 mL
50 mM 0.1142 mL 0.5708 mL 1.1417 mL 2.2834 mL 2.8542 mL
100 mM 0.0571 mL 0.2854 mL 0.5708 mL 1.1417 mL 1.4271 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Methyl caffeate acid

Catalog No: CFN95561
CAS No: 3843-74-1
Price: $ / mg
Ginsenoside Rg2

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CAS No: 52286-74-5
Price: $60/20mg
Quercetin-3-O-glucuronide

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Price: $238/20mg
1-Dehydro-6-gingerdione

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Price: $258/10mg
Erianin

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Price: $118/20mg
Ginsenoside Rb3

Catalog No: CFN99966
CAS No: 68406-26-8
Price: $70/20mg
Ginsenoside MC

Catalog No: CFN95232
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Price: $318/10mg
Schisantherin D

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Price: $ / mg
4'-Hydroxywogonin

Catalog No: CFN98960
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Price: $268/10mg
Sodium houttuyfonate

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Price: $50/20mg
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