Cassyfiline | CAS:4030-51-7 | Manufacturer ChemFaces

Cassyfiline

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Description:

Cassyfiline and actinodaphnine show high activity against Mel-5 (IC 50 : 24.3 microM and 25.7 microM, respectively) and HL-60 (IC 50 : 19.9 microM and 15.4 microM, respectively).

In vitro:

Planta Med. 2002 Nov;68(11):1042-4.

Cytotoxic aporphine alkaloids from Cassytha filiformis.[Pubmed: 12451500]

METHODS AND RESULTS:
Purification of a cytotoxic crude alkaloid extract of Cassytha filiformis led to the isolation of four known aporphine alkaloids: neolitsine, dicentrine, cassythine (= Cassyfiline) and actinodaphnine. Their structures were determined by analysis of spectroscopic data. All isolated alkaloids were tested for their cytotoxic activities on cancer and non-cancer cell lines in vitro. Neolitsine was the most active against HeLa and 3T3 cells (IC 50 :21.6 microM, and 21.4 microM, respectively). Cassyfiline and actinodaphnine showed the highest activity against Mel-5 (IC 50 : 24.3 microM and 25.7 microM, respectively) and HL-60 (IC 50 : 19.9 microM and 15.4 microM, respectively).
CONCLUSIONS:
This is the first report on the cytotoxic activity of C. filiformis extract and of neolitsine and Cassyfiline. Furthermore, the complete NMR data of Cassyfiline and actinodaphnine are given here for the first time.

Cassyfiline Description

Source:	The herbs of Cassytha filiformis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Cassyfiline
Price:
CAS No.:	4030-51-7
Catalog No.:	CFN97889
Molecular Formula:	C₁₉H₁₉NO₅
Molecular Weight:	341.4 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The herbs of Cassytha filiformis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Cytotoxic Compound Library Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.9291 mL	14.6456 mL	29.2912 mL	58.5823 mL	73.2279 mL
5 mM	0.5858 mL	2.9291 mL	5.8582 mL	11.7165 mL	14.6456 mL
10 mM	0.2929 mL	1.4646 mL	2.9291 mL	5.8582 mL	7.3228 mL
50 mM	0.0586 mL	0.2929 mL	0.5858 mL	1.1716 mL	1.4646 mL
100 mM	0.0293 mL	0.1465 mL	0.2929 mL	0.5858 mL	0.7323 mL

CFN93031	Laetanine	72361-67-2	313.35	C₁₈H₁₉NO₄
CFN90492	Laurolitsine	5890-18-6	313.34	C₁₈H₁₉NO₄
CFN99528	Norisoboldine	23599-69-1	313.35	C₁₈H₁₉NO₄
CFN96271	Norglaucine hydrochloride	39945-41-0	377.9	C₂₀H₂₄ClNO₄
CFN96155	Dehydroformouregine	107633-69-2	337.4	C₂₀H₁₉NO₄
CFN89485	6-Formyl-1,2,9,10-tetramethoxy-6a,7-dehydroaporphine	2101836-45-5	367.39	C₂₁H₂₁NO₅
CFN97889	Cassyfiline	4030-51-7	341.4	C₁₉H₁₉NO₅
CFN96039	1,2-Methylenedioxy-3,10,11-trimethoxynoraporphine	14050-90-9	355.4	C₂₀H₂₁NO₅
CFN97932	Aporheine	2030-53-7	279.3	C₁₈H₁₇NO₂
CFN97947	Neolitsine	2466-42-4	323.4	C₁₉H₁₇NO₄