Catharanthine Tartrate | CAS:2648-21-5

Catharanthine Tartrate

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Description:

Catharanthine Tartrate is an anti-tumor drug. Catharanthine Tartrate binds with DNA in a mode of groove binding, Se(Ⅳ)can inhibit the binding of Catharanthine Tartrate and DNA.

Targets:

DNA/RNA Synthesis

In vitro:

CN20071097400

Synthesizing method of vinorelbine tartrate[Reference: WebLink]

METHODS AND RESULTS:
The invention discloses a synthesis method of vinorelbine bitartrate which is characterized in that the method includes following steps: (1) having the Catharanthine Tartrate and vindoline as initial material, reacting with ferric trichloride and hydrochloric acid (2) reacting the above product with the sldium borohydride to get dehydrated vinblastine (3) ring-opening the dehydrated vinblastine by trifluoroacetic anhydride and rearranging to obtain the vinorelbine bitartrate.
CONCLUSIONS:
The method has a low production cost and a high yield and has a good application future.

Catharanthine Tartrate Description

Source:	The herbs of Catharanthus roseus (L.) G.Don
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

《Journal of Huazhong Normal University(Natural Sciences)》 2011-04

Study on the interaction between catharanthine tartrate and DNA by spectrometric method[Reference: WebLink]

METHODS AND RESULTS:
The interaction of Catharanthine Tartrate and DNA was studied using UV spectrometry,fluorescence spectrometry and fluorescent probe.The results showed that the fluorescence intensity of Catharanthine Tartrate was quenched in the presence of DNA,and this mechanism was judged as static quenching.The binding constant K at 25℃ and 40℃ were calculated as 5.38×104 and 5.85×102,and the binding sites number n as 1.405 and 0.8306.According to the binding constant K at 25℃ and 40℃,the thermodynamic parameters of the reaction of Catharanthine Tartrate and DNA were calculated as follows: ΔHm=-233.77 kJ·mol-1,ΔGm(298 K)=-27.0 kJ·mol-1,ΔSm(298 K)=-693.8 J·K-1·mol-1,and the main binding force between Catharanthine Tartrate and DNA is hydrogen bonding or van der Waals force according to thermodynamic parameters.
CONCLUSIONS:
The UV spectrometry test showed that as the DNA concentration increased,the blue shift of the absorbance peak occured and the absorbance decreased significantly,the results of fluorescence probe test further proved that Catharanthine Tartrate binds with DNA in a mode of groove binding.

《Journal of Hainan Normal University(Natural Science)》 2014-03

Study on the Effect of Se(Ⅳ) on the Interaction Between Catharanthine Tartrate and DNA[Reference: WebLink]

METHODS AND RESULTS:
The effect of Se(Ⅳ)on the interaction between Catharanthine Tartrate and DNA was studied by fluorescence spectrometry, UV spectroscopy and viscosity method. The results showed that the addition of Se(Ⅳ)changed the main binding force of Catharanthine Tartrate and DNA from hydrogen bond and van der Waals force into electrostatic force, and the binding mode from groove binding into electrostatic binding.
CONCLUSIONS:
The change of binding constant and the UV spectroscopy results showed that Se(Ⅳ)can inhibit the binding of Catharanthine Tartrate and DNA.

Product Name	Catharanthine Tartrate
Price:	$100 / 20mg
CAS No.:	2648-21-5
Catalog No.:	CFN90318
Molecular Formula:	C₂₁H₂₄N₂O₂.C₄H₆O₆
Molecular Weight:	486.40 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The herbs of Catharanthus roseus (L.) G.Don
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Alkaloids Compound Library DNA/RNA Synthesis Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.0559 mL	10.2796 mL	20.5592 mL	41.1184 mL	51.398 mL
5 mM	0.4112 mL	2.0559 mL	4.1118 mL	8.2237 mL	10.2796 mL
10 mM	0.2056 mL	1.028 mL	2.0559 mL	4.1118 mL	5.1398 mL
50 mM	0.0411 mL	0.2056 mL	0.4112 mL	0.8224 mL	1.028 mL
100 mM	0.0206 mL	0.1028 mL	0.2056 mL	0.4112 mL	0.514 mL

CFN97456	11,12-De(methylenedioxy)danuphylline	888482-17-5	426.5	C₂₃H₂₆N₂O₆
CFN99459	Methyl chanofruticosinate	14050-92-1	410.5	C₂₃H₂₆N₂O₅
CFN96107	Apparicine	2122-36-3	264.4	C₁₈H₂₀N₂
CFN97329	Ibogaine	83-74-9	310.4	C₂₀H₂₆N₂O
CFN96649	Tabernanthine	83-94-3	310.44	C₂₀H₂₆N₂O
CFN92252	Voacangine	510-22-5	368.5	C₂₂H₂₈N₂O₃
CFN96068	Conopharyngine	76-98-2	398.5	C₂₃H₃₀N₂O₄
CFN96069	19(S)-Hydroxyconopharyngine	16790-93-5	414.5	C₂₃H₃₀N₂O₅
CFN96176	Crassanine	16790-92-4	414.5	C₂₃H₃₀N₂O₅
CFN99765	Catharanthine	2468-21-5	336.43	C₂₁H₂₄N₂O₂