Structure Identification: |
Zhongguo Zhong Yao Za Zhi. 2009 Aug;34(15):1930-4. | Cycloartane triterpenoid of Cimicifuga foetida.[Pubmed: 19894537] | To study cycloartane triterpenoid of Cimicifuga foetida and their osteoclast inhibition activity. METHODS AND RESULTS: The compounds were isolated and purified by normal and reversed phase column chromatographic methods. Structures were identified by spectroscopic analyses. Their osteoclast inhibition activity was then studied.Thirteen cycloartane triterpenoids were isolated from the rhizomes of C. foetida and were characterized as 25-O-acetyl-cimigenol (1), cimigenol (2), cimicidanol (3), 26-deoxyactein (4), asiaticoside A (5), 23-epi-26-deoxyactein (6), actein (7), 12beta-hydroxycimigenol (8), cimiside E (9), (23R, 24S) 25-O-acetyl-cimigenol-3-O-beta-D-xylopyranoside (10), (23R, 24S) cimigenol-3-O-beta-D-xylopyranoside (11), cimicifugoside H1 (12) and Cimicifugoside H2 (13). CONCLUSIONS: Compound 5 was isolated from this genus for the first time, compound 7 was isolated firstly from the plant and compound 2, 7, 10 and 11 exhibit osteoclast inhibition activity. |
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