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Cinchonain IIb
Cinchonain IIb
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Cinchonain IIb
Price:
CAS No.: 85022-68-0
Catalog No.: CFN89461
Molecular Formula: C39H32O15
Molecular Weight: 740.66 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Source: The barks of Kandelia candel (L.) DRUCE.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Cinchonain IIb shows high radical scavenging activity and reducing power.
In vitro:
Journal of the Brazilian Chemical Society, 2011, 22(11):2087-2093.
Phenylpropanoid Substituted Flavan-3-ols from Trichilia catigua and their In Vitro Antioxidative Activity[Reference: WebLink]

METHODS AND RESULTS:
The new phenylpropanoid substituted flavan-3-ol apocynin E, together with eight known compounds, epicatechin, procyanidin B2, procyanidin B4, procyanidin C1, cinchonain Ia, cinchonain Ib, Cinchonain IIb, and Cinchonain IIa were isolated from an acetone-H2O extract of the air-dried stem bark of Trichilia catigua. The cinchonain Ia e Ib were reevaluated to its estereochemistry. All the compounds were characterized by spectroscopic analysis including 1D and 2D nuclear magnetic resonance (NMR) and mass spectrometry (MS) of their peracetate derivatives. The absolute configuration of the phenylpropanoid moiety was determined by circular dichroism (CD) spectra and by analyzing the anisotropic effects in the Dreiding model and nuclear Overhauser effect (NOESY NMR) experiments.
CONCLUSIONS:
The nine isolated compounds showed higher radical scavenging activity and reducing power than ascorbic acid and Trolox in the free-radical 2,2-diphenyl-1-picrylhydrazyl and Fe3+-Fe2+ reduction assay systems.
Cinchonain IIb Description
Source: The barks of Kandelia candel (L.) DRUCE.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
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PMID: 28005066

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IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.3501 mL 6.7507 mL 13.5015 mL 27.0029 mL 33.7537 mL
5 mM 0.27 mL 1.3501 mL 2.7003 mL 5.4006 mL 6.7507 mL
10 mM 0.135 mL 0.6751 mL 1.3501 mL 2.7003 mL 3.3754 mL
50 mM 0.027 mL 0.135 mL 0.27 mL 0.5401 mL 0.6751 mL
100 mM 0.0135 mL 0.0675 mL 0.135 mL 0.27 mL 0.3375 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Chemical & Pharmaceutical Bulletin, 2008, 33(8):3142-3152.
Tannins and Related Compounds. XXXI. Isolation and Characterization of Proanthocyanidins in Kandelia candel (L.) DRUCE[Reference: WebLink]

METHODS AND RESULTS:
Together with propelargonidin dimers (14, 15 and 16), and procyanidin trimers (23, 24 and 25) of common types, two novel proanthocyanidin dimers, kandelins A-1 (12) and A-2 (13), and four trimers, kandelins B-1 (19), B-2 (20), B-3 (21) and B-4 (22), which all contain a phenylpropanoid substituent in the upper flavan unit, have been isolated from the bark of Kandelia candel (L.) DRUCE (Rhizophoraceae). Spectroscopic evidence combined with chemical studies involving acid-catalyzed thiolytic degradation permitted the assignment of their structures.
CONCLUSIONS:
The presence in this plant source of flavan-3-ols, (+)-afzelechin (2), (+)-catechin (3), (-)-epicatechin (4) and (+)-gallocatechin (5), known proanthocyanidins B-1 (8), B-2 (9), C-1 (17) and trimer (18), and cinchonain Ia (6), cinchonain Ib (7), cinchonain IIa (10) and Cinchonain IIb (11) was also demonstrated.
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