Science | Nature | Cell | View More
Natural Products
Clausine D
Clausine D
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Clausine D
Price:
CAS No.: 142846-95-5
Catalog No.: CFN97821
Molecular Formula: C18H17NO2
Molecular Weight: 279.34 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Yellow powder
Source: The herbs of Clausena excavata
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
More Impact Factor than five Cite...
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Our products had been exported to the following research institutions and universities, And still growing.
  • Donald Danforth Plant Science C... (USA)
  • Universidad de Buenos Aires (Argentina)
  • Universite de Lille1 (France)
  • Leibniz-Institut für Pflanzenb... (Germany)
  • University of Minnesota (USA)
  • University of Perugia (Italy)
  • Guangzhou Institutes of Biomedi... (China)
  • Helmholtz Zentrum München (Germany)
  • Tohoku University (Japan)
  • Cornell University (USA)
  • Warszawski Uniwersytet Medyczny (Poland)
  • More...
Package
Featured Products
More...
Flavokawain C

Catalog No: CFN90741
CAS No: 56798-34-6
Price: $238/10mg
Jionoside A1

Catalog No: CFN90809
CAS No: 120444-60-2
Price: $238/5mg
Genistin

Catalog No: CFN90250
CAS No: 529-59-9
Price: $40/20mg
Schizandrin A

Catalog No: CFN99922
CAS No: 61281-38-7
Price: $40/20mg
Niga-ichigoside F1

Catalog No: CFN91060
CAS No: 95262-48-9
Price: $318/20mg
Rhmannioside D

Catalog No: CFN90216
CAS No: 81720-08-3
Price: $158/20mg
11-Hydroxy-sugiol

Catalog No: CFN90366
CAS No: 88664-08-8
Price: $490/5mg
Terpineol

Catalog No: CFN92688
CAS No: 98-55-5
Price: $30/20mg
Ginsenoside Rg5

Catalog No: CFN92643
CAS No: 186763-78-0
Price: $238/20mg
Ginsenoside F5

Catalog No: CFN95034
CAS No: 189513-26-6
Price: $298/20mg
Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Clausine D and clausine F show significant antiplatelet aggregation activity, due to inhibition of the formation of thromboxane A2.
Targets: PAFR
In vitro:
Biochim Biophys Acta. 1994 Sep 28;1201(1):1-6.
Antiplatelet effects of clausine D isolated from Clausena excavata.[Pubmed: 7918571 ]

METHODS AND RESULTS:
Clausine D inhibited concentration-dependently the aggregation and release reaction of washed rabbit platelets induced by arachidonic acid and collagen, without affecting those induced by U46619, PAF and thrombin. The IC50 values of Clausine D on arachidonic acid- and collagen-induced platelet aggregation were calculated to be 9.0 +/- 1.1 and 58.9 +/- 0.9 microM, respectively. Thromboxane B2 and prostaglandin D2 formation in platelets caused by arachidonic acid were also suppressed. Clausine D inhibited increased intracellular concentration of calcium in platelets caused by arachidonic acid and collagen, and also abolished the generation of inositol monophosphate caused by arachidonic acid, but not that by collagen, U46619, PAF and thrombin. In human citrated platelet-rich plasma, Clausine D inhibited the secondary phase, but not the primary phase, of aggregation induced by epinephrine and ADP.
CONCLUSIONS:
These results indicate that the antiplatelet effect of Clausine D is due to inhibition of the formation of thromboxane A2.
Clausine D Description
Source: The herbs of Clausena excavata
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
New Products More...
Ganolucidic acid B

Catalog No: CFN95513
CAS No: 98683-75-1
Price: $413/5mg
Batatasin V

Catalog No: CFN95320
CAS No: 65817-45-0
Price: $318/5mg
Lappaol F

Catalog No: CFN95069
CAS No: 69394-17-8
Price: $368/10mg
Caffeic acid 4-O-glucuronide

Catalog No: CFN95382
CAS No: 1093679-71-0
Price: $/mg
Ganosinensic acid C

Catalog No: CFN95567
CAS No: 2231756-23-1
Price: $413/5mg
6alpha-Hydroxydehydropachymic acid

Catalog No: CFN95412
CAS No: 176390-67-3
Price: $413/5mg
(R)-Mucronulatol

Catalog No: CFN95492
CAS No: 57128-11-7
Price: $318/10mg
Isonemerosin

Catalog No: CFN95008
CAS No: 181524-79-8
Price: $268/20mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.5799 mL 17.8993 mL 35.7987 mL 71.5973 mL 89.4967 mL
5 mM 0.716 mL 3.5799 mL 7.1597 mL 14.3195 mL 17.8993 mL
10 mM 0.358 mL 1.7899 mL 3.5799 mL 7.1597 mL 8.9497 mL
50 mM 0.0716 mL 0.358 mL 0.716 mL 1.4319 mL 1.7899 mL
100 mM 0.0358 mL 0.179 mL 0.358 mL 0.716 mL 0.895 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Chem Pharm Bull (Tokyo). 1992 Apr;40(4):1069-71.
Clausine D and -F, two new 4-prenylcarbazole alkaloids from Clausena excavata.[Pubmed: 1525939]

METHODS AND RESULTS:
Two new 4-prenylcarbazole alkaloids, Clausine D (1) and -F (3) were isolated from the stem bark of Clausena excavata. Their structures were elucidated by spectral methods.
CONCLUSIONS:
Both of Clausine D (1) and -F (3) showed significant antiplatelet aggregation activity.
CFN89173Glycoborinine233279-39-5279.33C18H17NO2
CFN96594Carbazole86-74-8167.21C12H9N
CFN977773-Methyl-9H-carbazol-2-ol24224-30-4197.23C13H11NO
CFN98862Glycozolinine5257-08-9197.2 C13H11NO
CFN97821Clausine D142846-95-5279.34C18H17NO2
CFN97840Demethylmurrayanine123497-84-7211.22C13H9NO2
CFN91484Murrayanine723-97-7225.2C14H11NO2
CFN91823Clausine E182261-83-2241.2C14H11NO3
CFN97428Clausine Z866111-14-0227.2 C13H9NO3
CFN97800Clausine I182261-94-5241.24C14H11NO3
Featured Products
Flavokawain C

Catalog No: CFN90741
CAS No: 56798-34-6
Price: $238/10mg
Jionoside A1

Catalog No: CFN90809
CAS No: 120444-60-2
Price: $238/5mg
Genistin

Catalog No: CFN90250
CAS No: 529-59-9
Price: $40/20mg
Schizandrin A

Catalog No: CFN99922
CAS No: 61281-38-7
Price: $40/20mg
Niga-ichigoside F1

Catalog No: CFN91060
CAS No: 95262-48-9
Price: $318/20mg
Rhmannioside D

Catalog No: CFN90216
CAS No: 81720-08-3
Price: $158/20mg
11-Hydroxy-sugiol

Catalog No: CFN90366
CAS No: 88664-08-8
Price: $490/5mg
Terpineol

Catalog No: CFN92688
CAS No: 98-55-5
Price: $30/20mg
Ginsenoside Rg5

Catalog No: CFN92643
CAS No: 186763-78-0
Price: $238/20mg
Ginsenoside F5

Catalog No: CFN95034
CAS No: 189513-26-6
Price: $298/20mg
Tags: buy Clausine D | Clausine D supplier | purchase Clausine D | Clausine D cost | Clausine D manufacturer | order Clausine D | Clausine D distributor
1 Building, No. 176, CheCheng East Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Copyright© 2011-2023 | ChemFaces all rights reserved | Tel: +86-27-84237683
E-mail:manager@chemfaces.com
payment