Clausine D | CAS:142846-95-5 | Manufacturer ChemFaces

Clausine D

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Description:

Clausine D and clausine F show significant antiplatelet aggregation activity, due to inhibition of the formation of thromboxane A2.

Targets:

PAFR

In vitro:

Biochim Biophys Acta. 1994 Sep 28;1201(1):1-6.

Antiplatelet effects of clausine D isolated from Clausena excavata.[Pubmed: 7918571 ]

METHODS AND RESULTS:
Clausine D inhibited concentration-dependently the aggregation and release reaction of washed rabbit platelets induced by arachidonic acid and collagen, without affecting those induced by U46619, PAF and thrombin. The IC50 values of Clausine D on arachidonic acid- and collagen-induced platelet aggregation were calculated to be 9.0 +/- 1.1 and 58.9 +/- 0.9 microM, respectively. Thromboxane B2 and prostaglandin D2 formation in platelets caused by arachidonic acid were also suppressed. Clausine D inhibited increased intracellular concentration of calcium in platelets caused by arachidonic acid and collagen, and also abolished the generation of inositol monophosphate caused by arachidonic acid, but not that by collagen, U46619, PAF and thrombin. In human citrated platelet-rich plasma, Clausine D inhibited the secondary phase, but not the primary phase, of aggregation induced by epinephrine and ADP.
CONCLUSIONS:
These results indicate that the antiplatelet effect of Clausine D is due to inhibition of the formation of thromboxane A2.

Clausine D Description

Source:	The herbs of Clausena excavata
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Clausine D
Price:
CAS No.:	142846-95-5
Catalog No.:	CFN97821
Molecular Formula:	C₁₈H₁₇NO₂
Molecular Weight:	279.34 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Yellow powder
Source:	The herbs of Clausena excavata
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-platelet aggregation Compound Library Alkaloids Compound Library PAFR Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.5799 mL	17.8993 mL	35.7987 mL	71.5973 mL	89.4967 mL
5 mM	0.716 mL	3.5799 mL	7.1597 mL	14.3195 mL	17.8993 mL
10 mM	0.358 mL	1.7899 mL	3.5799 mL	7.1597 mL	8.9497 mL
50 mM	0.0716 mL	0.358 mL	0.716 mL	1.4319 mL	1.7899 mL
100 mM	0.0358 mL	0.179 mL	0.358 mL	0.716 mL	0.895 mL

CFN98862	Glycozolinine	5257-08-9	197.2	C₁₃H₁₁NO
CFN97821	Clausine D	142846-95-5	279.34	C₁₈H₁₇NO₂
CFN97840	Demethylmurrayanine	123497-84-7	211.22	C₁₃H₉NO₂
CFN91484	Murrayanine	723-97-7	225.2	C₁₄H₁₁NO₂
CFN91823	Clausine E	182261-83-2	241.2	C₁₄H₁₁NO₃
CFN91427	Clausine G	186002-62-0	271.3	C₁₅H₁₃NO₄
CFN97428	Clausine Z	866111-14-0	227.2	C₁₃H₉NO₃
CFN97800	Clausine I	182261-94-5	241.24	C₁₄H₁₁NO₃
CFN97796	Clauszoline M	187110-72-1	227.22	C₁₃H₉NO₃
CFN92926	Curryangine	25488-37-3	331.45	C₂₃H₂₅NO