Clerosterol glucoside | CAS:123621-00-1

Clerosterol glucoside

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Clerosterol glucoside Description

Source:	The fresh fruits of Momordica charantia L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Cell Research:

Marine Drugs, 2013, 11(2):418-430.

Cytotoxic Effect of Clerosterol Isolated from Codium fragile on A2058 Human Melanoma Cells.[Reference: WebLink]

METHODS AND RESULTS:
The cytotoxic effects and mechanism of action of clerosterol(Clerosterol glucoside), isolated from the marine alga Codium fragile, were investigated in A2058 human melanoma cells. Clerosterol inhibited the growth of A2058 cells with an IC50 of 150 ÂµM and induced apoptotic cell death, as evidenced by DNA fragmentation, an increase in the number of sub-G1 hypodiploid cells and the presence of apoptotic bodies. Clerosterol treatment caused the loss of mitochondrial membrane potential. Alterations in the expression of apoptosis-associated proteins in response to clerosterol treatment included upregulation of Bax, downregulation of Bcl-2 and activation of caspases 3 and 9. The pan-caspase inhibitor treatment attenuated the expression of the active form of caspases and cell death induced by clerosterol.
CONCLUSIONS:
The present results show that clerosterol exerts its cytotoxic effect in A2058 human melanoma cells by caspases-dependent apoptosis.

Product Name	Clerosterol glucoside
Price:
CAS No.:	123621-00-1
Catalog No.:	CFN99351
Molecular Formula:	C₃₅H₅₈O₆
Molecular Weight:	574.8 g/mol
Purity:	>=98%
Type of Compound:	Steroids
Physical Desc.:	Powder
Source:	The fresh fruits of Momordica charantia L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Steroids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.7397 mL	8.6987 mL	17.3974 mL	34.7947 mL	43.4934 mL
5 mM	0.3479 mL	1.7397 mL	3.4795 mL	6.9589 mL	8.6987 mL
10 mM	0.174 mL	0.8699 mL	1.7397 mL	3.4795 mL	4.3493 mL
50 mM	0.0348 mL	0.174 mL	0.3479 mL	0.6959 mL	0.8699 mL
100 mM	0.0174 mL	0.087 mL	0.174 mL	0.3479 mL	0.4349 mL

CFN99351	Clerosterol glucoside	123621-00-1	574.8	C₃₅H₅₈O₆
CFN99480	22-Dehydroclerosterol glucoside	143815-99-0	572.8	C₃₅H₅₆O₆
CFN98000	Stigmasterol glucoside	19716-26-8	574.8	C₃₅H₅₈O₆
CFN98713	Daucosterol	474-58-8	576.9	C₃₅H₆₀O₆
CFN99866	Sitoindoside I	18749-71-8	815.3	C₅₁H₉₀O₇
CFN99217	Ikshusterol 3-O-glucoside	112137-81-2	592.9	C₃₅H₆₀O₇
CFN99824	alpha-Spinasterol glucoside	1745-36-4	574.8	C₃₅H₅₈O₆