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Crovatin
Crovatin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Crovatin
Price: $413 / 5mg
CAS No.: 142409-09-4
Catalog No.: CFN90374
Molecular Formula: C21H26O6
Molecular Weight: 374.43 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Cryst.
Source: The herbs of Croton caudatus Geisel.var.tomentosus Hook
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / $351.1 / In-stock
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
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Description: Reference standards.
Crovatin Description
Source: The herbs of Croton caudatus Geisel.var.tomentosus Hook
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.6707 mL 13.3536 mL 26.7073 mL 53.4145 mL 66.7682 mL
5 mM 0.5341 mL 2.6707 mL 5.3415 mL 10.6829 mL 13.3536 mL
10 mM 0.2671 mL 1.3354 mL 2.6707 mL 5.3415 mL 6.6768 mL
50 mM 0.0534 mL 0.2671 mL 0.5341 mL 1.0683 mL 1.3354 mL
100 mM 0.0267 mL 0.1335 mL 0.2671 mL 0.5341 mL 0.6677 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Planta Med. 2002 Mar;68(3):274-7.
Croblongifolin, a new anticancer clerodane from Croton oblongifolius.[Pubmed: 11914970]

METHODS AND RESULTS:
A new furoclerodane, croblongifolin, together with one known clerodane, Crovatin and one known labdane, nidorellol, were isolated from the stem bark of Croton oblongifolius. Structures were established based on spectroscopic and X-ray analysis.
CONCLUSIONS:
Croblongifolin showed a significant cytotoxicity against various human tumor cell lines including HEP-G2, SW620, CHAGO, KATO3 and BT474.
CFN99836Hardwickiic acid1782-65-6316.4 C20H28O3
CFN89315Methyl 2alpha-hydroxyhardwickiate50428-93-8346.46C21H30O4
CFN97799Hautriwaic acid18411-75-1332.44C20H28O4
CFN89305Dehydrohautriwaic acid51905-84-1330.42C20H26O4
CFN97754Methyl dodonate A349534-70-9344.45C21H28O4
CFN97755Methyl dodonate A acetate349487-98-5386.49C23H30O5
CFN90480Columbin 546-97-4358.39C20H22O6
CFN98538Isocolumbin471-54-5358.39C20H22O6
CFN90388Levatin140670-84-4328.36C19H20O5
CFN90375Croverin76475-17-7370.40C21H22O6
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