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Cyclo(Leu-Ala)
Cyclo(Leu-Ala)
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Cyclo(Leu-Ala)
Price: $238 / 10mg
CAS No.: 1803-60-7
Catalog No.: CFN90283
Molecular Formula: C9H16N2O2
Molecular Weight: 184.24 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: From Penicillium oxalicum
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $77.9 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Cyclo(Leu-Ala) is the Diketopiperazine.
In vitro:
Nat Prod Res. 2014;28(5):344-6.
Antimicrobial metabolites from a novel halophilic actinomycete Nocardiopsis terrae YIM 90022.[Pubmed: 24236566]

METHODS AND RESULTS:
A quinoline alkaloid 1 and five known compounds (2-6) were isolated from a novel halophilic actinomycete Nocardiopsis terrae YIM 90022, and their structures were determined by spectroscopic studies as 4-oxo-1,4-dihydroquinoline-3-carboxamide (1), p-hydroxybenzoic acid (2), N-acetyl-anthranilic acid (3), indoly-3-carboxylic acid (4), cyclo(Trp-Gly) (5) and Cyclo(Leu-Ala) (6). Compound 1 was isolated from natural resources for the first time.
CONCLUSIONS:
Compounds 1 and 3 showed antimicrobial activities against some plant pathogens.
Cyclo(Leu-Ala) Description
Source: From Penicillium oxalicum
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.4277 mL 27.1385 mL 54.277 mL 108.5541 mL 135.6926 mL
5 mM 1.0855 mL 5.4277 mL 10.8554 mL 21.7108 mL 27.1385 mL
10 mM 0.5428 mL 2.7139 mL 5.4277 mL 10.8554 mL 13.5693 mL
50 mM 0.1086 mL 0.5428 mL 1.0855 mL 2.1711 mL 2.7139 mL
100 mM 0.0543 mL 0.2714 mL 0.5428 mL 1.0855 mL 1.3569 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
CFN91573Cyclo(Ala-Val)15136-26-2170.2C8H14N2O2
CFN90284Cyclo(Ile-Ala)90821-99-1184.24C9H16N2O2
CFN90264Cyclo(Ile-Val)104068-43-1212.29C11H20N2O2
CFN90289Cyclo(Ile-Leu)91741-17-2226.32C12H22N2O2
CFN90283Cyclo(Leu-Ala)1803-60-7184.24C9H16N2O2
CFN90291Cyclo(Leu-Val)5625-50-3212.29C11H20N2O2
CFN90288Cyclo(Leu-Leu)1436-27-7226.32C12H22N2O2
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