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Cyclo(Pro-Trp)
Cyclo(Pro-Trp)
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Cyclo(Pro-Trp)
Price: $238 / 10mg
CAS No.: 67889-75-2
Catalog No.: CFN90277
Molecular Formula: C16H17N3O2
Molecular Weight: 283.33 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: From Pantoea agglomerans
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $99.2 / In-stock
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Cyclo(Pro-Trp) and cyclo(Phe-Pro) show broad spectrum antibacterial properties.
Targets: Antifection
In vitro:
Pharmazie. 1999 Oct;54(10):772-5.
Antimicrobial activity of selected cyclic dipeptides.[Pubmed: 10563376]
Cyclic dipeptides are products of rational drug design, which may exhibit both antimicrobial and antitumor properties. The aim of this study was to investigate both the antimicrobial effects of the cyclic dipeptides cyclo(L-phenylalanyl-L-prolyl), cyclo(L-tyrosyl-L-prolyl), cyclo(L-tryptophanyl-L-prolyl) and cyclo(L-tryptophanyl-L-tryptophanyl) and the effects of these cyclic dipeptides on the gastrointestinal epithelium in vitro. Furthermore, a relevant solvent for the possible pharmaceutical application of the products was sought concurrently.
METHODS AND RESULTS:
The antimicrobial effect of the cyclic dipeptides was assayed using the Kirby-Bauer disc diffusion assay against Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus, Bacillus subtilis, Streptococcus pneumoniae, Candida albicans, Aspergillus niger and Penicillium notatum. The effect of the cyclic dipeptides on the gastrointestinal epithelium was assessed by changes in alkaline phosphatase expression of HT-29 cells. Cyclo(Pro-Trp) and cyclo(Phe-Pro) show broad spectrum antibacterial properties and cyclo(Trp-Pro) and cyclo(Trp-Trp) show broad spectrum antifungal properties. The maturation of the gastrointestinal cells was enhanced by cyclo(Phe-Pro), cyclo(Tyr-Pro), cyclo(Trp-Trp) and cyclo(Trp-Pro).
CONCLUSIONS:
The activity of these cyclic dipeptides thus indicates potential application of these compounds as pharmacological agents.
Cyclo(Pro-Trp) Description
Source: From Pantoea agglomerans
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.5295 mL 17.6473 mL 35.2945 mL 70.5891 mL 88.2363 mL
5 mM 0.7059 mL 3.5295 mL 7.0589 mL 14.1178 mL 17.6473 mL
10 mM 0.3529 mL 1.7647 mL 3.5295 mL 7.0589 mL 8.8236 mL
50 mM 0.0706 mL 0.3529 mL 0.7059 mL 1.4118 mL 1.7647 mL
100 mM 0.0353 mL 0.1765 mL 0.3529 mL 0.7059 mL 0.8824 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
CFN96983Emeheterone117333-12-7322.36C19H18N2O3
CFN90280Cyclo(Phe-Hpro)1016899-94-7260.30C14H16N2O3
CFN90279Cyclo(Tyr-Hpro)813461-21-1276.29C14H16N2O4
CFN90277Cyclo(Pro-Trp)67889-75-2283.33C16H17N3O2
CFN96937Demethoxyfumitremorgin C111768-16-2349.43C21H23N3O2
CFN96930Fumitremorgin C118974-02-0379.46C22H25N3O3
CFN89011Fumitremorgin B12626-17-4479.57C27H33N3O5
CFN90627Heterophyllin B145459-19-4778.95C40H58N8O8
CFN91927Rubiyunnanin C1261030-04-9828.91C43H52N6O11
CFN95187Astin A151201-75-1586.5C25H33N5O7Cl2
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