Cyclo(Pro-Trp) | CAS:67889-75-2 | Manufacturer ChemFaces

Cyclo(Pro-Trp)

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Description:

Cyclo(Pro-Trp) and cyclo(Phe-Pro) show broad spectrum antibacterial properties.

Targets:

Antifection

In vitro:

Pharmazie. 1999 Oct;54(10):772-5.

Antimicrobial activity of selected cyclic dipeptides.[Pubmed: 10563376]

Cyclic dipeptides are products of rational drug design, which may exhibit both antimicrobial and antitumor properties. The aim of this study was to investigate both the antimicrobial effects of the cyclic dipeptides cyclo(L-phenylalanyl-L-prolyl), cyclo(L-tyrosyl-L-prolyl), cyclo(L-tryptophanyl-L-prolyl) and cyclo(L-tryptophanyl-L-tryptophanyl) and the effects of these cyclic dipeptides on the gastrointestinal epithelium in vitro. Furthermore, a relevant solvent for the possible pharmaceutical application of the products was sought concurrently.
METHODS AND RESULTS:
The antimicrobial effect of the cyclic dipeptides was assayed using the Kirby-Bauer disc diffusion assay against Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus, Bacillus subtilis, Streptococcus pneumoniae, Candida albicans, Aspergillus niger and Penicillium notatum. The effect of the cyclic dipeptides on the gastrointestinal epithelium was assessed by changes in alkaline phosphatase expression of HT-29 cells. Cyclo(Pro-Trp) and cyclo(Phe-Pro) show broad spectrum antibacterial properties and cyclo(Trp-Pro) and cyclo(Trp-Trp) show broad spectrum antifungal properties. The maturation of the gastrointestinal cells was enhanced by cyclo(Phe-Pro), cyclo(Tyr-Pro), cyclo(Trp-Trp) and cyclo(Trp-Pro).
CONCLUSIONS:
The activity of these cyclic dipeptides thus indicates potential application of these compounds as pharmacological agents.

Cyclo(Pro-Trp) Description

Source:	From Pantoea agglomerans
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Cyclo(Pro-Trp)
Price:	$238 / 10mg
CAS No.:	67889-75-2
Catalog No.:	CFN90277
Molecular Formula:	C₁₆H₁₇N₃O₂
Molecular Weight:	283.33 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	From Pantoea agglomerans
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antibacterial Compound Library Antifungal Compound Library Alkaloids Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.5295 mL	17.6473 mL	35.2945 mL	70.5891 mL	88.2363 mL
5 mM	0.7059 mL	3.5295 mL	7.0589 mL	14.1178 mL	17.6473 mL
10 mM	0.3529 mL	1.7647 mL	3.5295 mL	7.0589 mL	8.8236 mL
50 mM	0.0706 mL	0.3529 mL	0.7059 mL	1.4118 mL	1.7647 mL
100 mM	0.0353 mL	0.1765 mL	0.3529 mL	0.7059 mL	0.8824 mL

CFN95187	Astin A	151201-75-1	586.5	C₂₅H₃₃N₅O₇Cl₂
CFN95188	Astin B	151201-76-2	586.5	C₂₅H₃₃N₅O₇Cl₂
CFN95189	Astin C	148057-23-2	570.5	C₂₅H₃₃N₅O₆Cl₂
CFN93198	Segetalin A	161875-97-4	609.72	C₃₁H₄₃N₇O₆
CFN91404	Beauvericin	26048-05-5	784.0	C₄₅H₅₇N₃O₉
CFN95745	zeta-Clausenamide	136173-85-8	279.3	C₁₈H₁₇NO₂
CFN96110	Cyclo(D-Phe-L-Pro)	26488-24-4	244.3	C₁₄H₁₆N₂O₂
CFN96129	Cyclo(L-Phe-L-Pro)	3705-26-8	244.3	C₁₄H₁₆N₂O₂
CFN90276	Cyclo(Tyr-Pro)	5654-84-2	260.29	C₁₄H₁₆N₂O₃
CFN90278	Cyclo(Tyr-Phe)	5147-17-1	310.35	C₁₈H₁₈N₂O₃