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Cymarin
Cymarin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Cymarin
Price:
CAS No.: 508-77-0
Catalog No.: CFN70386
Molecular Formula: C30H44O9
Molecular Weight: 548.7 g/mol
Purity: >=98%
Type of Compound: Steroids
Physical Desc.: Powder
Source: The herbs of Convallaria majalis L.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Cymarin exhibits potent cytotoxicity against a human solid tumor cell line A549 (human lung carcinoma), while being inactive on murine leukemic cells (L1210).
In vitro:
Phytotherapy Researth,2003, 17(5):568-570.
Inhibitory effect of Adonis amurensis components on tube‐like formation of human umbilical venous cells.[Reference: WebLink]

METHODS AND RESULTS:
Antiangiogenic activity‐guided fractionation and isolation carried out on the methanol extract of Adonis amurensis led to the identification of three compounds, namely Cymarin, cymarol, and cymarilic acid. Amongst the three compounds, cymarilic acid was isolated from this plant for the first time. This compound showed no significant cytotoxicity against tumor cell lines but was found to be strongly inhibitory toward tube formation induced by human umbilical venous endothelial (HUVE) cells.
CONCLUSIONS:
Cymarin and cymarol exhibited potent cytotoxicity against a human solid tumor cell line A549 (human lung carcinoma), while being inactive on murine leukemic cells (L1210).
Cymarin Description
Source: The herbs of Convallaria majalis L.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.8225 mL 9.1124 mL 18.2249 mL 36.4498 mL 45.5622 mL
5 mM 0.3645 mL 1.8225 mL 3.645 mL 7.29 mL 9.1124 mL
10 mM 0.1822 mL 0.9112 mL 1.8225 mL 3.645 mL 4.5562 mL
50 mM 0.0364 mL 0.1822 mL 0.3645 mL 0.729 mL 0.9112 mL
100 mM 0.0182 mL 0.0911 mL 0.1822 mL 0.3645 mL 0.4556 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Journal of Pharmacy & Pharmacology, 1961, 13(1):279-282.
The isolation of cymarin and periplocymarin from the seeds of Castilloa elastica Cerv.[Reference: WebLink]

METHODS AND RESULTS:
Two known cardiac glycosides, Cymarin and periploCymarin have been isolated from the seeds of the South American rubber tree, Castilloa elastica.
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CAS No: 79233-15-1
Price: $288/20mg
Corynoxeine

Catalog No: CFN98154
CAS No: 630-94-4
Price: $148/20mg
Chebulinic acid

Catalog No: CFN92296
CAS No: 18942-26-2
Price: $138/20mg
Sinomenine

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CAS No: 115-53-7
Price: $30/20mg
Crategolic acid

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CAS No: 4373-41-5
Price: $80/20mg
Ginsenoside Rh1

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CAS No: 63223-86-9
Price: $60/20mg
Glycyrrhizic acid

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CAS No: 1405-86-3
Price: $40/20mg
Deapi-platycodin D

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Irigenin

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