Dehydroevodiamine hydrochloride | CAS:75853-60-0

Dehydroevodiamine hydrochloride

ChemFaces products have been cited in many studies from excellent and top scientific journals

Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC

How to Order

Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com

Delivery time

Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal

Citing Use of our Products

More Impact Factor than five Cite...

* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

Featured Products

More...

Saikosaponin A

Catalog No: CFN99987
CAS No: 20736-09-8
Price: $80/20mg

Capsaicin

Catalog No: CFN99917
CAS No: 404-86-4
Price: $50/20mg

Fangchinoline

Catalog No: CFN99167
CAS No: 436-77-1
Price: $40/20mg

Lupenone

Catalog No: CFN99681
CAS No: 1617-70-5
Price: $178/20mg

Ginsenoside Rh1

Catalog No: CFN99970
CAS No: 63223-86-9
Price: $60/20mg

Piceatannol

Catalog No: CFN99024
CAS No: 10083-24-6
Price: $40/20mg

Purpurin

Catalog No: CFN92566
CAS No: 81-54-9
Price: $30/20mg

20(R)-Ginsenoside Rh2

Catalog No: CFN90340
CAS No: 112246-15-8
Price: $70/20mg

Pinobanksin

Catalog No: CFN98917
CAS No: 548-82-3
Price: $338/5mg

Quercetin 3-O-glucoside-7-O-rhamno...

Catalog No: CFN90738
CAS No: 18016-58-5
Price: $538/5mg

Description:

Dehydroevodiamine hydrochloride has novel anti-cholinesterase and antiamnesic activities, it inhibits acetylcholinesterase activity in a dose-dependent and non-competitive manner(IC50=37.8 microM); its potent antiamnesic effect is thought to be due to the combined effects of acetylcholinesterase inhibition and the known cerebral blood flow enhancement. Dehydroevodiamine hydrochloride (0.1-0.3 mg/kg iv) can increase the cerebral blood flow recorded from the surface of the supra-sylvian gyrus in anesthetized cats, suggest that it selectively increases cerebral blood flow.

Targets:

AChR

In vivo:

J Nat Prod. 1994 Mar;57(3):387-9.

Increased feline cerebral blood flow induced by dehydroevodiamine hydrochloride from Evodia rutaecarpa.[Pubmed: 8201313]

METHODS AND RESULTS:
Dehydroevodiamine hydrochloride (0.1-0.3 mg/kg iv), which was isolated from the leaves of Evodia rutaecarpa, increased the cerebral blood flow recorded from the surface of the supra-sylvian gyrus in anesthetized cats. This action reached a maximum 1-4 min after injection and continued for 10 min. However, the compound had negligible effects on other cardiorespiratory functions at the doses examined.
CONCLUSIONS:
These results suggest that the compound selectively increases cerebral blood flow.

Dehydroevodiamine hydrochloride Description

Source:	The leaves of Evodia rutaecarpa.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Animal Research:

Planta Med. 1996 Oct;62(5):405-9.

Novel anticholinesterase and antiamnesic activities of dehydroevodiamine, a constituent of Evodia rutaecarpa.[Pubmed: 8923803 ]

To find a new compound with antiamnesic activity, we screened 29 natural products for their abilities to inhibit acetylcholinesterase and reverse scopolamine-induced amnesia.
METHODS AND RESULTS:
Among the plants tested Evodia rutaecarpa Bentham showed a strong inhibitory effect on acetylcholinesterase in vitro and an anti-amnesic effect in vivo. By sequential fractionation of E. rutaecarpa, the active component was finally identified as Dehydroevodiamine hydrochloride (DHED). DHED inhibited acetylcholinesterase activity in a dose-dependent and non-competitive manner. The IC50 value of DHED is 37.8 microM. A single administration of DHED to rats (6.25 mg/kg) significantly reversed the scopolamine-induced memory impairment in a passive avoidance test. The antiamnesic effect of DHED was more potent than that of tacrine which is the only drug for Alzheimer's disease approved by FDA. This potent antiamnesic effect of DHED was thought to be due to the combined effects of acetylcholinesterase inhibition and the known cerebral blood flow enhancement.
CONCLUSIONS:
These results indicate that DHED has novel anti-cholinesterase and antiamnesic activities and might have therapeutic potential in various disorders including Alzheimer's disease.

Product Name	Dehydroevodiamine hydrochloride
Price:
CAS No.:	75853-60-0
Catalog No.:	CFN96360
Molecular Formula:	C₁₉H₁₆N₃O
Molecular Weight:	302.4 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The leaves of Evodia rutaecarpa.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticholinesterase Compound Library Memory enhancers Compound Library Anti-hypoxic Compound Library Alkaloids Compound Library AChR Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.3069 mL	16.5344 mL	33.0688 mL	66.1376 mL	82.672 mL
5 mM	0.6614 mL	3.3069 mL	6.6138 mL	13.2275 mL	16.5344 mL
10 mM	0.3307 mL	1.6534 mL	3.3069 mL	6.6138 mL	8.2672 mL
50 mM	0.0661 mL	0.3307 mL	0.6614 mL	1.3228 mL	1.6534 mL
100 mM	0.0331 mL	0.1653 mL	0.3307 mL	0.6614 mL	0.8267 mL

CFN97337	Rutaecarpine	84-26-4	287.3	C₁₈H₁₃N₃O
CFN96232	7beta-Hydroxyrutaecarpine	163815-35-8	303.3	C₁₈H₁₃N₃O₂
CFN98895	1-Hydroxyrutaecarpine	53600-24-1	303.3	C₁₈H₁₃N₃O₂
CFN99993	Evodiamine	518-17-2	303.36	C₁₉H₁₇N₃O
CFN96360	Dehydroevodiamine hydrochloride	75853-60-0	302.4	C₁₉H₁₆N₃O
CFN90944	Dehydroevodiamine	67909-49-3	301.4	C₁₉H₁₅N₃O
CFN91442	Goshuyamide I	126223-62-9	305.4	C₁₉H₁₉N₃O