Structure Identification: |
J Antibiot (Tokyo). 1993 Jun;46(6):979-84. | Delaminomycins, novel nonpeptide extracellular matrix receptor antagonist and a new class of potent immunomodulator. II. Physico-chemical properties and structure elucidation of delaminomycin A.[Pubmed: 8393852] |
METHODS AND RESULTS:
Delaminomycins, novel extracellular matrix receptor antagonists, have been isolated from a culture broth of Streptomyces albulus MJ202-72F3. The structure of Delaminomycin A was determined to be 3-[[2-[(3E,5E)-2,8-dihydroxy-7-methyl-3,5-decadienyl]- 1,6,8- trimethyl-1,2,4a,5,6,7,8,8a-octahydro-1-naphthyl]carbonyl]-5- hydroxypyrrolidine-2,4-dione by analyses of spectral properties and chemical studies. | US 5527820 A[P]. 1996. | Antibiotics having immunosuppressive activity, delaminomycins and processes for the production of the same[Reference: WebLink] |
As new antibiotics are obtained delaminomycins A, B and C having a formula (I) or (I') shown below, or salts thereof.
METHODS AND RESULTS:
Delaminomycins preferentially inhibit T cells and are useful as immunosuppressants, antineoplastic agents and antibacterial agents. ##STR1## wherein X is a hydroxyl group for Delaminomycin A, a methoxy group for delaminomycin B and a hydrogen atom for delaminomycin C. |
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