Pseudolaric acid C2 | CAS:82508-35-8 | Manufacturer ChemFaces

Pseudolaric acid C2

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Description:

Reference standards.

In vitro:

Yao Xue Xue Bao. 2014 Aug;49(8):1169-74.

Metabolic pathway and metabolites of total diterpene acid isolated from Pseudolarix kaempferi.[Pubmed: 25322560]

The preliminary metabolic profile of total diterpene acid (TDA) isolated from Pseudolarix kaempferi was investigated by using in vivo and in vitro tests.
METHODS AND RESULTS:
Pseudolaric acid C2 (PC2) was identified as the predominant metabolite in plasma, urine, bile and feces after both oral and intravenous administrations to rats using HPLC-UV and HPLC-ESI/MS(n), and demethoxydeacetoxypseudolaric acid B (DDPB), a metabolite proposed to be the glucoside of PC2 (PC2G), as well as pseudolaric acid C (PC), pseudolaric acid A (PA), pseudolaric acid A O-beta-D glucopyranoside (PAG), pseudolaric acid B O-beta-D glucopyranoside (PBG) and deacetylpseudolaric acid A (DPA) originated from TDA could also be detected. It was demonstrated by tests that the metabolism of TDA is independent of intestinal microflora, and neither of pepsin and trypsin is in charge of metabolism of TDA, TDA is also stable in both pH environments of gastric tract and intestinal tract. The metabolites of TDA in whole blood in vitro incubation were found to be PC2, DDPB and PC2G, which demonstrated that the metabolic reaction of TDA in vivo is mainly occurred in blood and contributed to be the hydrolysis of plasma esterase to ester bond, as well as the glucosylation reaction.
CONCLUSIONS:
These results clarified the metabolic pathway of TDA for the first time, which is of great significance to the in vivo active form and acting mechanism research of P. kaempferi.

Pseudolaric acid C2 Description

Source:	The root barks of Pseudolarix amabilis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Pseudolaric acid C2
Price:
CAS No.:	82508-35-8
Catalog No.:	CFN93342
Molecular Formula:	C₂₂H₂₆O₈
Molecular Weight:	418.44 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The root barks of Pseudolarix amabilis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Diterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.3898 mL	11.9491 mL	23.8983 mL	47.7966 mL	59.7457 mL
5 mM	0.478 mL	2.3898 mL	4.7797 mL	9.5593 mL	11.9491 mL
10 mM	0.239 mL	1.1949 mL	2.3898 mL	4.7797 mL	5.9746 mL
50 mM	0.0478 mL	0.239 mL	0.478 mL	0.9559 mL	1.1949 mL
100 mM	0.0239 mL	0.1195 mL	0.239 mL	0.478 mL	0.5975 mL

CFN98914	Erythrodiol	545-48-2	442.7	C₃₀H₅₀O₂
CFN97276	Artemisinic acid	80286-58-4	234.3	C₁₅H₂₂O₂
CFN99727	Pectolinarin	28978-02-1	622.57	C₂₉H₃₄O₁₅
CFN90644	Sibiricaxanthone B	241125-81-5	538.45	C₂₄H₂₆O₁₄