Desmethylrocaglamide | CAS:146408-78-8

Desmethylrocaglamide

ChemFaces products have been cited in many studies from excellent and top scientific journals

Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC

How to Order

Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com

Delivery time

Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal

Citing Use of our Products

More Impact Factor than five Cite...

* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

Featured Products

More...

Pinostrobin

Catalog No: CFN98739
CAS No: 480-37-5
Price: $218/20mg

Malvidin-3-O-glucoside chloride

Catalog No: CFN92049
CAS No: 7228-78-6
Price: $238/10mg

N1,N10-Bis(p-coumaroyl)spermidine

Catalog No: CFN99248
CAS No: 114916-05-1
Price: $ /

Guaijaverin

Catalog No: CFN98211
CAS No: 22255-13-6
Price: $138/20mg

Momordicine II

Catalog No: CFN95167
CAS No: 91590-75-9
Price: $318/10mg

Isoliquiritin

Catalog No: CFN99155
CAS No: 5041-81-6
Price: $100/20mg

Wogonin

Catalog No: CFN97089
CAS No: 632-85-9
Price: $30/20mg

Vitamin D3

Catalog No: CFN90027
CAS No: 67-97-0
Price: $40/20mg

Kaempferol-3-O-galactoside

Catalog No: CFN92079
CAS No: 23627-87-4
Price: $238/10mg

Pinobanksin

Catalog No: CFN98917
CAS No: 548-82-3
Price: $338/10mg

Description:

Desmethylrocaglamide is a novel inducer of cellular differentiation using HL-60 promyelocytic cells, it may be a drug for the prevention and therapy of cancer. It also has insecticidal activity.

In vitro:

Phytochemistry. 2001 May;57(1):57-64.

Insecticidal flavaglines and other compounds from Fijian Aglaia species.[Pubmed: 11336261]

METHODS AND RESULTS:
Bioassays with lipophilic crude extracts of four Fijian Aglaia species against Spodoptera littoralis displayed strong insecticidal activity for A. basiphylla and A. gracilis, whereas A. archboldiana and A. vitiensis did not have any significant effects. The insect toxicity of A. basiphylla was caused by the well known benzofuran flavaglines rocaglamide, Desmethylrocaglamide and aglafoline. In contrast, A. gracilis contained four related pyrimidinone derivatives in the root and stem bark, including two new congeners named marikarin and 3'-hydroxymarikarin. Moreover, two new putrescine bisamides, secoodorine and secopiriferine, a new benzopyran flavagline. desacetylaglain A. and a new norsesquiterpene were isolated from the leaves together with three known bisamides and 3-hydroxy-5,7,4'-trimethoxyflavone.
CONCLUSIONS:
The structures of the new compounds were elucidated by spectroscopic methods. Comparative feeding assays within the active pyrimidinone flavaglines showed that the free hydroxy group in aromatic ring A of marikarin diminishes insecticidal activity.

Desmethylrocaglamide Description

Source:	The twigs of Aglaia odorata.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Cell Research:

Anticancer Res. 2001 May-Jun;21(3B):1763-70.

Discovery of novel inducers of cellular differentiation using HL-60 promyelocytic cells.[Pubmed: 11497257]

Non-physiological inducers of terminal differentiation have been used as novel therapies for the prevention and therapy of cancer.
METHODS AND RESULTS:
We have used cultured HL-60 promyelocytic cells to monitor differentiation, proliferation and cell death events as induced by a large set of extracts derived from plants. Screening of more than 1400 extracts led to the discovery of 34 with potent activity (ED50 <8 mg/ml). Bioassay-guided fractionation led to the isolation of zapotin and 2',5,6-trimethoxyflavone as active principles from Casimiroa edulis, dibenzyltrisulfide and 2-[(phenylmethyl)dithio]ethanol as active principles from Petiveria alliacea, and Desmethylrocaglamide from Aglaia ponapensis. Zapotin demonstrated the most favorable biological profile in that induction of differentiation correlated with proliferation arrest, and a lack of cytotoxicity.
CONCLUSIONS:
We conclude that the HL-60 cell model is a useful system for the discovery of novel pharmacophores with potential to suppress the process of carcinogenesis, and that flavonoids may be especially useful in this capacity.

Product Name	Desmethylrocaglamide
Price:
CAS No.:	146408-78-8
Catalog No.:	CFN89458
Molecular Formula:	C₂₈H₂₉NO₇
Molecular Weight:	491.53 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The twigs of Aglaia odorata.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Cancer chemoprevention Compound Library Insecticides Compound Library Activators Compound Library Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.0345 mL	10.1723 mL	20.3446 mL	40.6893 mL	50.8616 mL
5 mM	0.4069 mL	2.0345 mL	4.0689 mL	8.1379 mL	10.1723 mL
10 mM	0.2034 mL	1.0172 mL	2.0345 mL	4.0689 mL	5.0862 mL
50 mM	0.0407 mL	0.2034 mL	0.4069 mL	0.8138 mL	1.0172 mL
100 mM	0.0203 mL	0.1017 mL	0.2034 mL	0.4069 mL	0.5086 mL

CFN99609	Rocaglaol	147059-46-9	434.5	C₂₆H₂₆O₆
CFN89458	Desmethylrocaglamide	146408-78-8	491.53	C₂₈H₂₉NO₇
CFN97339	Rocaglamide	84573-16-0	505.6	C₂₉H₃₁NO₇
CFN99875	3'-Hydroxyrocaglamide	189322-67-6	521.6	C₂₉H₃₁NO₈
CFN99876	3'-Methoxyrocaglamide	189322-69-8	535.6	C₃₀H₃₃NO₈
CFN99660	Dehydroaglaiastatin	155595-93-0	524.6	C₃₁H₂₈N₂O₆
CFN89448	3'-Hydroxydehydroaglaiastatin	259143-58-3	540.56	C₃₁H₂₈N₂O₇