Desoxyrhaponticin | CAS:30197-14-9 | Manufacturer ChemFaces

Desoxyrhaponticin

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Description:

Desoxyrhaponticin is an agent that is potentially effective in controlling postprandial hyperglycemia in diabetes. Desoxyrhaponticin could be considered as a promising fatty acid synthase(FAS) inhibitor, it could inhibit intracellular FAS activity and downregulate FAS expression in human breast cancer MCF-7 cells.

Targets:

Fatty Acid Synthase

In vitro:

Food & Function, 2014 , 5 (2) :251-6.

Inhibitory effect of desoxyrhaponticin and rhaponticin, two natural stilbene glycosides from the Tibetan nutritional food Rheum tanguticum Maxim. ex Balf., on fatty acid synthase and human breast cancer cells.[Pubmed: 24362821]

Fatty acid synthase (FAS) has attracted more and more attention as a potential target for cancer treatment. Natural FAS inhibitors are emerging as potential therapeutic agents to treat cancer. Rheum tanguticum Maxim. ex Balf. (rhubarb) is a traditional Chinese nutritional food and has been reported to possess a variety of biological activities, including the ability to induce the apoptosis of cancer cells.
METHODS AND RESULTS:
This study indicates that Desoxyrhaponticin (DC) and rhaponticin (RC), two stilbene glycosides from rhubarb, could be considered as promising FAS inhibitors. We found that both DC and RC could inhibit intracellular FAS activity and downregulate FAS expression in human breast cancer MCF-7 cells. In addition, the apoptotic effect of DC on human cancer cells was announced for the first time.
CONCLUSIONS:
Since FAS plays a key role in the biosynthesis pathway of fatty acids in cancer cells, these findings suggest that DC has potential applications in the prevention and treatment of cancer.

In vivo:

J Pharmacol Exp Ther. 2007 Jan;320(1):38-46.

Desoxyrhaponticin (3,5-dihydroxy-4'-methoxystilbene 3-O-beta-D-glucoside) inhibits glucose uptake in the intestine and kidney: In vitro and in vivo studies.[Pubmed: 17038511 ]

Rhubarb extracts have been reported to improve oral glucose tolerance in diabetic animals.
METHODS AND RESULTS:
In the present study we have investigated the antidiabetic actions of Desoxyrhaponticin, a major stilbene in rhubarb, as a glucose uptake inhibitor. Desoxyrhaponticin was demonstrated to inhibit glucose uptake in rabbit intestinal membrane vesicles as well as in rat everted gut sleeves, with IC50 values of 148.3 and 30.9 microM, respectively. Kinetics studies revealed that Desoxyrhaponticin is a competitive inhibitor of glucose uptake in both systems. Moreover, Desoxyrhaponticin could reduce glucose uptake in the intestinal membrane vesicles of both normal and diabetic rats. In addition, glucose uptake in the renal membrane vesicles of both normal and diabetic rats was reduced by Desoxyrhaponticin. Under the inhibition of Desoxyrhaponticin, uptake of glucose in both the intestinal and renal membrane vesicles of the normal rats was no different from that of the diabetic rats. The IC50 values of the uptake inhibition in the renal membrane vesicles of normal and diabetic rats were 118.8 and 115.7 microM, respectively. In a type 2 diabetic animal model in which rats have been treated with streptozotocin at the neonatal stage, postprandial hyperglycemia was significantly suppressed by oral administration of this compound (300 mg/kg b.wt.).
CONCLUSIONS:
These results suggest that Desoxyrhaponticin is an agent that is potentially effective in controlling postprandial hyperglycemia in diabetes. The in vivo antidiabetic action of this compound can be explained, in part at least, by inhibition of glucose transport in the small intestine and inhibition of glucose reabsorption in the kidney.

Desoxyrhaponticin Description

Source:	The roots of Rumex obtusifolius L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Desoxyrhaponticin
Price:	$238 / 20mg
CAS No.:	30197-14-9
Catalog No.:	CFN90911
Molecular Formula:	C₂₁H₂₄O₈
Molecular Weight:	404.4 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Powder
Source:	The roots of Rumex obtusifolius L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Inhibitors Compound Library Antihyperglycemic Compound Library Phenols Compound Library Fatty Acid Synthase Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.4728 mL	12.364 mL	24.728 mL	49.456 mL	61.82 mL
5 mM	0.4946 mL	2.4728 mL	4.9456 mL	9.8912 mL	12.364 mL
10 mM	0.2473 mL	1.2364 mL	2.4728 mL	4.9456 mL	6.182 mL
50 mM	0.0495 mL	0.2473 mL	0.4946 mL	0.9891 mL	1.2364 mL
100 mM	0.0247 mL	0.1236 mL	0.2473 mL	0.4946 mL	0.6182 mL

CFN95320	Batatasin V	65817-45-0	288.3	C₁₇H₂₀O₄
CFN90397	Pterostilbene	537-42-8	256.30	C₁₆H₁₆O₃
CFN95199	3-Hydroxy-4',5-dimethoxystilbene	58436-29-6	256.3	C₁₆H₁₆O₃
CFN90874	Trimethoxystilbene	22255-22-7	270.3	C₁₇H₁₈O₃
CFN89540	3,5-Dimethoxy-3'-hydroxybibenzyl	168281-05-8	258.31	C₁₆H₁₈O₃
CFN90118	Desoxyanisoin	120-44-5	256.30	C₁₆H₁₆O₃
CFN91179	Arundinin	148225-38-1	350.4	C₂₂H₂₂O₄
CFN95511	2-(2,4-Dihydroxyphenyl)-5,6-methylenedioxybenzofuran (ABF)	67121-26-0	270.2	C₁₅H₁₀O₅
CFN98791	Resveratrol	501-36-0	228.2	C₁₄H₁₂O₃
CFN90895	Triacetylresveratrol	42206-94-0	354.4	C₂₀H₁₈O₆