Diethanolamine | CAS:111-42-2 | Manufacturer ChemFaces

Diethanolamine

ChemFaces products have been cited in many studies from excellent and top scientific journals

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Thioacetamide, dimethylnitrosamine and diethanolamine can induce liver damage in rats.

Targets:

TLR | TNF-α | IL Receptor

In vitro:

J Nanosci Nanotechnol. 2014 Jul;14(7):5426-9.

Diethanolamine-modified magnetic fluorescent Fe3O4@ZnS nanoparticles for ultrasensitive detection and removal of Cu2+.[Pubmed: 24758043]

Currently, growing attention has been paid to the sensitive determination and removal of Cu2+ because excessive levels of Cu2+ could do harm to organisms.
METHODS AND RESULTS:
Herein, a novel Diethanolamine-modified magnetic fluorescent Fe3O4@ZnS nanoparticle (MFNP) for simultaneous detection and removal of Cu2+ was designed and synthesized through dithiocarbamate linkage strategy. The characterization of MFNP was confirmed by transmission electron microscope (TEM), infrared (IR) and emission spectra.
CONCLUSIONS:
The results showed that MFNP could quantificationally detect Cu2+ with high sensitivity and selectivity under a broad pH range (pH 4.5-9). The removal of Cu2+ was achieved by the aggregation-induced sedimentation (AIS) strategy and by external magnetic field.

Aquat Toxicol. 2010 Aug 15;99(2):212-22.

Molecular effects of diethanolamine exposure on Calanus finmarchicus (Crustacea: Copepoda).[Pubmed: 20537412]

Of particular interest is the use of alkanolamines such as Diethanolamine (DEA) in the removal of CO(2) from natural gas and for CO(2) capture following fossil fuel combustion.In an attempt to assess the potential effects of alkanolamines in the marine environment, a key species in the North Atlantic, the planktonic copepod Calanus finmarchicus, was studied for molecular effects following sublethal exposure to Diethanolamine.
METHODS AND RESULTS:
Diethanolamine-induced alterations in transcriptome and metabolome profiling were assessed using a suppression subtractive hybridization (SSH) gene library method and high resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR), respectively. Together, SSH and HR-MAS NMR offer complementary screening tools for the assessment of molecular responses of C. finmarchicus to Diethanolamine and can be used in the study of other chemicals and organisms. Concentration-response and time-response relationships between Diethanolamine exposure and single gene transcription were investigated using quantitative PCR. Specific relationships were found between Diethanolamine exposure and the transcription of genes involved in protein catabolism (ubiquitin-specific protease-7), metal ion homeostasis (ferritin) and defence against oxidative stress (gamma-glutamylcysteine synthase, glutathione synthase and Cu/Zn-superoxide dismutase). Finally, similar transcription patterns were observed for a number of different genes following exposure to Diethanolamine, which indicates analogous mechanisms of toxicity and response.

Diethanolamine Description

Source:	The herbs of Senecio dunedin
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Bioorg Med Chem. 2013 Apr 15;21(8):2199-209.

Improving the immunostimulatory potency of diethanolamine-containing lipid A mimics.[Pubmed: 23490149]

Lipid A is the active principal of gram negative bacterial lipopolysaccharide (LPS) in the activation of Toll-like receptor 4 (TLR4). Given the important role TLR4 plays in innate immunity and the development of adaptive immune responses, ligands that can modulate TLR4-mediated signaling have great therapeutic potential. Recently, we have reported a series of monophosphorylated lipid A mimics as potential ligands of TLR4, in which a Diethanolamine moiety is employed to replace the reducing end (d-glucosamine).
METHODS AND RESULTS:
In this paper, we describe the synthesis of two further Diethanolamine-containing lipid A mimics, 3 and 4, in an effort to mimic more closely the di-phosphate nature of natural lipid A. Both mimic 3, with an additional phosphate on the Diethanolamine acyclic scaffold, and mimic 4, with a terminal carboxylic acid moiety as a phosphate bioisostere, serve to increase the potency of the immunostimulatory response induced, as measured by the induction of the cytokines TNF-α, IL-6, and IL-1β in the human monocytic cell line THP-1. In addition, mechanistic studies involving the known TLR4 antagonist lipid IVa confirm TLR4 as the target of the Diethanolamine-containing lipid A mimics.

Animal Research:

Toxicology & Applied Pharmacology ,1973,26(2):299-313.

Sensitivity of several serum enzymes for the detection of thioacetamide-, dimethylnitrosamine- and diethanolamine-induced liver damage in rats[Reference: WebLink]

Studies were conducted to compare the sensitivity of different methods of assessing liver damage and to identify enzymes in serum which respond quantitatively to low doses of hepatotoxins.
METHODS AND RESULTS:
Male adult Sprague-Dawley rats were killed 18 hr after single po doses of thioacetamide (TA), dimethylnitrosamine (DMN) or Diethanolamine (DEA). Serum sorbitol dehydrogenase activity increased when 9.4 mg TA/kg or 5.1 mg DMN/kg was given and the activity of 7 other enzymes in serum increased when larger doses were given. Serum concentrations of arginine decreased and ornithine increased when 25.4 mg TA/kg or 13.7 mg DMN/kg was given. When 800 mg/kg of Diethanolamine (DEA) was given the serum activity of sorbitol dehydrogenase, isocitrate dehydrogenase, fructose-1-phosphate aldolase, glutamic-pyruvic transaminase, glutamic-oxaloacetic transaminase and malic dehydrogenase increased. When the dose was increased to 1600 mg/kg the serum activity of ornithine carbamyl transferase, glutamic dehydrogenase, fructose-1,6-phosphate aldolase and lactic dehydrogenase increased. Serum concentrations of urea increased and arginine decreased when 800 mg DEA/kg was given.
CONCLUSIONS:
Activities of several enzymes were dose-dependent. Minimal morphological changes were seen in liver sections at dosage levels of each compound below those required to produce changes in serum enzyme activity. Sorbitol dehydrogenase was the most sensitive serum parameter studied.

Product Name	Diethanolamine
Price:
CAS No.:	111-42-2
Catalog No.:	CFN00073
Molecular Formula:	C₄H₁₁NO₂
Molecular Weight:	105.14 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Oil
Source:	The herbs of Senecio dunedin
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Hepatotoxicity Compound Library Alkaloids Compound Library TNF-α Inhibitor Library TLR Inhibitor Library IL Receptor Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	9.5111 mL	47.5556 mL	95.1113 mL	190.2226 mL	237.7782 mL
5 mM	1.9022 mL	9.5111 mL	19.0223 mL	38.0445 mL	47.5556 mL
10 mM	0.9511 mL	4.7556 mL	9.5111 mL	19.0223 mL	23.7778 mL
50 mM	0.1902 mL	0.9511 mL	1.9022 mL	3.8045 mL	4.7556 mL
100 mM	0.0951 mL	0.4756 mL	0.9511 mL	1.9022 mL	2.3778 mL

CFN00071	Demanyl phosphate	6909-62-2	169.12	C₄H₁₂NO₄P
CFN00073	Diethanolamine	111-42-2	105.14	C₄H₁₁NO₂
CFN00074	2-(Dimethylamino)ethanol	108-01-0	89.14	C₄H₁₁NO
CFN00022	2-(Dimethylamino)ethanesulfonic acid	637-95-6	153.2	C₄H₁₁NO₃S
CFN00034	2-Dimethylaminoethylphosphonic acid	14596-56-6	153.12	C₄H₁₂NO₃P
CFN00045	4-Amino-4-methyl-2-pentanone	625-04-7	115.17	C₆H₁₃NO
CFN00046	1-Amino-2-methylpropan-2-ol	2854-16-2	89.14	C₄H₁₁NO
CFN00047	2-(Dimethylaminomethyl)-2-propanol	14123-48-9	117.19	C₆H₁₅NO
CFN00066	3-(Carboxymethylamino)propanoic acid	505-72-6	147.13	C₅H₉NO₄
CFN00067	Choline sulphate	4858-96-2	183.23	C₅H₁₃NO₄S