Science | Nature | Cell | View More
Natural Products
Diethanolamine
Diethanolamine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Diethanolamine
Price:
CAS No.: 111-42-2
Catalog No.: CFN00073
Molecular Formula: C4H11NO2
Molecular Weight: 105.14 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Oil
Source: The herbs of Senecio dunedin
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Instituto Politécnico de Bragan?a (Portugal)
  • Florida International University (USA)
  • John Innes Centre (United Kingdom)
  • University of Eastern Finland (Finland)
  • Universidad Veracuzana (Mexico)
  • Hamdard University (India)
  • Universidade Católica Portuguesa (Portugal)
  • Korea Food Research Institute(K... (Korea)
  • Korea Institute of Oriental Med... (Korea)
  • Monash University Sunway Campus (Malaysia)
  • Biotech R&D Institute (USA)
  • More...
Package
Featured Products
Dihydroevocarpine

Catalog No: CFN92786
CAS No: 15266-35-0
Price: $268/10mg
Zeaxanthin

Catalog No: CFN90234
CAS No: 144-68-3
Price: $ / mg
Corilagin

Catalog No: CFN90176
CAS No: 23094-69-1
Price: $50/20mg
Kaempferol-3-O-(2',6'-di-O-trans-p...

Catalog No: CFN92386
CAS No: 121651-61-4
Price: $ / mg
Zearalenone

Catalog No: CFN91172
CAS No: 17924-92-4
Price: $50/20mg
Phloretin

Catalog No: CFN97040
CAS No: 60-82-2
Price: $40/20mg
Silychristin

Catalog No: CFN90243
CAS No: 33889-69-9
Price: $218/20mg
Procyanidin B3

Catalog No: CFN99559
CAS No: 23567-23-9
Price: $238/10mg
Pilloin

Catalog No: CFN96503
CAS No: 32174-62-2
Price: $218/10mg
Curcumin

Catalog No: CFN98686
CAS No: 458-37-7
Price: $30/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Thioacetamide, dimethylnitrosamine and diethanolamine can induce liver damage in rats.
Targets: TLR | TNF-α | IL Receptor
In vitro:
J Nanosci Nanotechnol. 2014 Jul;14(7):5426-9.
Diethanolamine-modified magnetic fluorescent Fe3O4@ZnS nanoparticles for ultrasensitive detection and removal of Cu2+.[Pubmed: 24758043]
Currently, growing attention has been paid to the sensitive determination and removal of Cu2+ because excessive levels of Cu2+ could do harm to organisms.
METHODS AND RESULTS:
Herein, a novel Diethanolamine-modified magnetic fluorescent Fe3O4@ZnS nanoparticle (MFNP) for simultaneous detection and removal of Cu2+ was designed and synthesized through dithiocarbamate linkage strategy. The characterization of MFNP was confirmed by transmission electron microscope (TEM), infrared (IR) and emission spectra.
CONCLUSIONS:
The results showed that MFNP could quantificationally detect Cu2+ with high sensitivity and selectivity under a broad pH range (pH 4.5-9). The removal of Cu2+ was achieved by the aggregation-induced sedimentation (AIS) strategy and by external magnetic field.
Aquat Toxicol. 2010 Aug 15;99(2):212-22.
Molecular effects of diethanolamine exposure on Calanus finmarchicus (Crustacea: Copepoda).[Pubmed: 20537412]
Of particular interest is the use of alkanolamines such as Diethanolamine (DEA) in the removal of CO(2) from natural gas and for CO(2) capture following fossil fuel combustion.In an attempt to assess the potential effects of alkanolamines in the marine environment, a key species in the North Atlantic, the planktonic copepod Calanus finmarchicus, was studied for molecular effects following sublethal exposure to Diethanolamine.
METHODS AND RESULTS:
Diethanolamine-induced alterations in transcriptome and metabolome profiling were assessed using a suppression subtractive hybridization (SSH) gene library method and high resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR), respectively. Together, SSH and HR-MAS NMR offer complementary screening tools for the assessment of molecular responses of C. finmarchicus to Diethanolamine and can be used in the study of other chemicals and organisms. Concentration-response and time-response relationships between Diethanolamine exposure and single gene transcription were investigated using quantitative PCR. Specific relationships were found between Diethanolamine exposure and the transcription of genes involved in protein catabolism (ubiquitin-specific protease-7), metal ion homeostasis (ferritin) and defence against oxidative stress (gamma-glutamylcysteine synthase, glutathione synthase and Cu/Zn-superoxide dismutase). Finally, similar transcription patterns were observed for a number of different genes following exposure to Diethanolamine, which indicates analogous mechanisms of toxicity and response.
Diethanolamine Description
Source: The herbs of Senecio dunedin
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Hederagenin 3-O-(2-O-acetyl-alpha-...

Catalog No: CFN95355
CAS No: 87562-05-8
Price: $318/10mg
2''-O-acetylsaikosaponin A

Catalog No: CFN95085
CAS No: 102934-42-9
Price: $318/5mg
Nomilinic acid

Catalog No: CFN95559
CAS No: 35930-20-2
Price: $318/5mg
Physalin X

Catalog No: CFN95329
CAS No: 72497-31-5
Price: $318/5mg
Tetillapyrone

Catalog No: CFN95404
CAS No: 363136-43-0
Price: $413/5mg
24-Hydroxymomordicine III

Catalog No: CFN95169
CAS No: N/A
Price: $318/5mg
(-)-Epiafzelechin 3-O-gallate

Catalog No: CFN95081
CAS No: 108907-43-3
Price: $388/5mg
Cordifolioside A

Catalog No: CFN95040
CAS No: 155179-20-7
Price: $318/10mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 9.5111 mL 47.5556 mL 95.1113 mL 190.2226 mL 237.7782 mL
5 mM 1.9022 mL 9.5111 mL 19.0223 mL 38.0445 mL 47.5556 mL
10 mM 0.9511 mL 4.7556 mL 9.5111 mL 19.0223 mL 23.7778 mL
50 mM 0.1902 mL 0.9511 mL 1.9022 mL 3.8045 mL 4.7556 mL
100 mM 0.0951 mL 0.4756 mL 0.9511 mL 1.9022 mL 2.3778 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Kinase Assay:
Bioorg Med Chem. 2013 Apr 15;21(8):2199-209.
Improving the immunostimulatory potency of diethanolamine-containing lipid A mimics.[Pubmed: 23490149]
Lipid A is the active principal of gram negative bacterial lipopolysaccharide (LPS) in the activation of Toll-like receptor 4 (TLR4). Given the important role TLR4 plays in innate immunity and the development of adaptive immune responses, ligands that can modulate TLR4-mediated signaling have great therapeutic potential. Recently, we have reported a series of monophosphorylated lipid A mimics as potential ligands of TLR4, in which a Diethanolamine moiety is employed to replace the reducing end (d-glucosamine).
METHODS AND RESULTS:
In this paper, we describe the synthesis of two further Diethanolamine-containing lipid A mimics, 3 and 4, in an effort to mimic more closely the di-phosphate nature of natural lipid A. Both mimic 3, with an additional phosphate on the Diethanolamine acyclic scaffold, and mimic 4, with a terminal carboxylic acid moiety as a phosphate bioisostere, serve to increase the potency of the immunostimulatory response induced, as measured by the induction of the cytokines TNF-α, IL-6, and IL-1β in the human monocytic cell line THP-1. In addition, mechanistic studies involving the known TLR4 antagonist lipid IVa confirm TLR4 as the target of the Diethanolamine-containing lipid A mimics.
Animal Research:
Toxicology & Applied Pharmacology ,1973,26(2):299-313.
Sensitivity of several serum enzymes for the detection of thioacetamide-, dimethylnitrosamine- and diethanolamine-induced liver damage in rats[Reference: WebLink]
Studies were conducted to compare the sensitivity of different methods of assessing liver damage and to identify enzymes in serum which respond quantitatively to low doses of hepatotoxins.
METHODS AND RESULTS:
Male adult Sprague-Dawley rats were killed 18 hr after single po doses of thioacetamide (TA), dimethylnitrosamine (DMN) or Diethanolamine (DEA). Serum sorbitol dehydrogenase activity increased when 9.4 mg TA/kg or 5.1 mg DMN/kg was given and the activity of 7 other enzymes in serum increased when larger doses were given. Serum concentrations of arginine decreased and ornithine increased when 25.4 mg TA/kg or 13.7 mg DMN/kg was given. When 800 mg/kg of Diethanolamine (DEA) was given the serum activity of sorbitol dehydrogenase, isocitrate dehydrogenase, fructose-1-phosphate aldolase, glutamic-pyruvic transaminase, glutamic-oxaloacetic transaminase and malic dehydrogenase increased. When the dose was increased to 1600 mg/kg the serum activity of ornithine carbamyl transferase, glutamic dehydrogenase, fructose-1,6-phosphate aldolase and lactic dehydrogenase increased. Serum concentrations of urea increased and arginine decreased when 800 mg DEA/kg was given.
CONCLUSIONS:
Activities of several enzymes were dose-dependent. Minimal morphological changes were seen in liver sections at dosage levels of each compound below those required to produce changes in serum enzyme activity. Sorbitol dehydrogenase was the most sensitive serum parameter studied.
Dihydroevocarpine

Catalog No: CFN92786
CAS No: 15266-35-0
Price: $268/10mg
Zeaxanthin

Catalog No: CFN90234
CAS No: 144-68-3
Price: $ / mg
Corilagin

Catalog No: CFN90176
CAS No: 23094-69-1
Price: $50/20mg
Kaempferol-3-O-(2',6'-di-O-trans-p...

Catalog No: CFN92386
CAS No: 121651-61-4
Price: $ / mg
Zearalenone

Catalog No: CFN91172
CAS No: 17924-92-4
Price: $50/20mg
Phloretin

Catalog No: CFN97040
CAS No: 60-82-2
Price: $40/20mg
Silychristin

Catalog No: CFN90243
CAS No: 33889-69-9
Price: $218/20mg
Procyanidin B3

Catalog No: CFN99559
CAS No: 23567-23-9
Price: $238/10mg
Pilloin

Catalog No: CFN96503
CAS No: 32174-62-2
Price: $218/10mg
Curcumin

Catalog No: CFN98686
CAS No: 458-37-7
Price: $30/20mg
Tags: buy Diethanolamine | Diethanolamine supplier | purchase Diethanolamine | Diethanolamine cost | Diethanolamine manufacturer | order Diethanolamine | Diethanolamine distributor