Dihydrobonducellin | CAS:103680-87-1 | Manufacturer ChemFaces

Dihydrobonducellin

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Description:

Dihydrobonducellin has immunopharmacological activity, it significantly inhibits the production of IL-2 and IFN-gamma in activated PBMC in a concentration-dependent manner.

Targets:

IL Receptor | IFN-γ

In vitro:

Molecules. 2009 May 12;14(5):1789-95.

Isolation and immunomodulatory effect of homoisoflavones and flavones from Agave sisalana Perrine ex Engelm.[Pubmed: 19471199]

METHODS AND RESULTS:
Three known flavones and seven known homoisoflavonoids were isolated from the methanolic extract of the leaves of Agave sisalanaPerrine ex Engelm. Their structures were elucidated on the basis of spectroscopic analysis. The isolated compounds were also evaluated for immunopharmacological activity. PBMC were used as target cells, and cell proliferation was determined by (3)H-thymidine uptake. (+/-)-3,9-Dihydroeucomin (4), Dihydrobonducellin (5), and 5,7-dihydroxy-3-(4'-hydroxybenzyl)-4-chromanone (7) showed inhibitory effects on PBMC proliferation activated by PHA with IC(50) values 19.4, 73.8, and 58.8 microM, respectively.
CONCLUSIONS:
All three compounds significantly inhibited the production of IL-2 and IFN-gamma in activated PBMC in a concentration-dependent manner.

Dihydrobonducellin Description

Source:	The herbs of Caesalpinia decapetala
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Cell Research:

Phytochemistry. 2004 Sep;65(17):2455-61.

Stimulating the production of homoisoflavonoids in cell suspension cultures of Caesalpinia pulcherrima using cork tissue.[Pubmed: 15381409 ]

It has previously been demonstrated that cork tissue increases the efficiency of the production of lipophilic secondary metabolites in diverse plant cell suspension cultures.
METHODS AND RESULTS:
In the present study, three new homoisoflavonoids--named Dihydrobonducellin, 2'-methoxyDihydrobonducellin, and 2'-methoxybonducellin--and bonducellin and isobonducellin were isolated from Caesalpinia pulcherrima cultured cells coincubated with cork tissue. Cork tissue increased the production of 2'-methoxybonducellin by about 7-fold relative to control cells, and more than 80% of the product was recoverable from the cork tissue. When cork tissue and methyl jasmonate or yeast extract were added simultaneously to the medium, the amount of 2'-methoxybonducellin produced increased further. The production of the other four homoisoflavonoids was enhanced by variable amounts.
CONCLUSIONS:
Our results indicate that the addition of cork tissue would be an effective technique for investigating formation of secondary metabolites that usually accumulate only in trace amounts.

Product Name	Dihydrobonducellin
Price:
CAS No.:	103680-87-1
Catalog No.:	CFN92828
Molecular Formula:	C₁₇H₁₆O₄
Molecular Weight:	284.3 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Cryst.
Source:	The herbs of Caesalpinia decapetala
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Immunomodulators Compound Library Flavonoids Compound Library IL Receptor Inhibitor Library IFN-γ Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.5174 mL	17.5871 mL	35.1741 mL	70.3482 mL	87.9353 mL
5 mM	0.7035 mL	3.5174 mL	7.0348 mL	14.0696 mL	17.5871 mL
10 mM	0.3517 mL	1.7587 mL	3.5174 mL	7.0348 mL	8.7935 mL
50 mM	0.0703 mL	0.3517 mL	0.7035 mL	1.407 mL	1.7587 mL
100 mM	0.0352 mL	0.1759 mL	0.3517 mL	0.7035 mL	0.8794 mL

CFN99229	3-Deoxysappanone B	113122-54-6	286.3	C₁₆H₁₄O₅
CFN99082	4-Demethyl-3,9-dihydroeucomin	107585-77-3	286.3	C₁₆H₁₄O₅
CFN96519	3,9-Dihydroeucomin	887375-68-0	300.31	C₁₇H₁₆O₅
CFN91144	4H-1-Benzopyran-4-one,2,3-dihydro-5-hydroxy-3-[(4-hydroxyphenyl)methyl]-7-methoxy-	108001-32-7	300.3	C₁₇H₁₆O₅
CFN91153	Loureiriol	479195-44-3	302.3	C₁₆H₁₄O₆
CFN96506	Eucomol	17934-12-2	316.31	C₁₇H₁₆O₆
CFN96517	7-O-Methyleucomol	17934-15-5	330.33	C₁₈H₁₈O₆
CFN99081	3'-Hydroxy-3,9-dihydroeucomin	107585-75-1	316.3	C₁₇H₁₆O₆
CFN97500	8-O-Demethyl-7-O-methyl-3,9-dihydropunctatin	93078-83-2	316.3	C₁₇H₁₆O₆
CFN91154	(3R)-5,7-Dihydroxy-6-methyl-3-(4'-hydroxybenzyl)chroman-4-one	84638-48-2	300.3	C₁₇H₁₆O₅