Dihydroguaiaretic acid | CAS:66322-34-7

Dihydroguaiaretic acid

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Product Name	Dihydroguaiaretic acid
Price:	$338 / 10mg
CAS No.:	66322-34-7
Catalog No.:	CFN97133
Molecular Formula:	C₂₀H₂₆O₄
Molecular Weight:	330.4 g/mol
Purity:	>=98%
Type of Compound:	Lignans
Physical Desc.:	Solid
Source:	The aerial parts of Saururus chinensis.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $164.6 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Dihydroguaiaretic acid Description

Source:	The aerial parts of Saururus chinensis.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Animal Research:

J Agric Food Chem. 2015 Mar 11;63(9):2442-8.

Acute larvicidal activity against mosquitoes and oxygen consumption inhibitory activity of dihydroguaiaretic acid derivatives.[Pubmed: 25669766]

(-)-Dihydroguaiaretic acid (DGA) and its derivatives having 3-hydroxyphenyl (3-OH-DGA) and variously substituted phenyl groups instead of 3-hydroxy-4-methoxyphenyl groups were synthesized to measure their larvicidal activity against the mosquito Culex pipiens Linnaeus, 1758 (Diptera: Culicidae).
METHODS AND RESULTS:
Compared with DGA and 3-OH-(-)-Dihydroguaiaretic acid (LC50 (M), 3.52 × 10(-5) and 4.57 × 10(-5), respectively), (8R,8'R)-lignan-3-ol (3) and its 3-Me (10), 2-OH (12), 3-OH (13), and 2-OMe (15) derivatives showed low potency (ca. 6-8 × 10(-5) M). The 4-Me derivative (11) showed the lowest potency (12.1 × 10(-5) M), and the 2-F derivative (4) showed the highest (2.01 × 10(-5) M). All of the synthesized compounds induced an acute toxic symptom against mosquito larvae, with potency varying with the type and position of the substituents.
CONCLUSIONS:
The 4-F derivative (6), which killed larvae almost completely within 45 min, suppressed the O2 consumption of the mitochondrial fraction, demonstrating that this compound inhibited mitochondrial O2 consumption contributing to a respiratory inhibitory activity.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Antioxidants Compound Library Neuroprotection Compound Library Hepatoprotective Compound Library Insecticides Compound Library Vasoprotective Compound Library Lignans Compound Library DNA/RNA Synthesis Inhibitor Library COX Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.0266 mL	15.1332 mL	30.2663 mL	60.5327 mL	75.6659 mL
5 mM	0.6053 mL	3.0266 mL	6.0533 mL	12.1065 mL	15.1332 mL
10 mM	0.3027 mL	1.5133 mL	3.0266 mL	6.0533 mL	7.5666 mL
50 mM	0.0605 mL	0.3027 mL	0.6053 mL	1.2107 mL	1.5133 mL
100 mM	0.0303 mL	0.1513 mL	0.3027 mL	0.6053 mL	0.7567 mL

CFN98539	Anwulignan	107534-93-0	328.41	C₂₀H₂₄O₄
CFN95501	erythro-Austrobailignan-6	114127-24-1	328.4	C₂₀H₂₄O₄
CFN92717	Schineolignin B	1352185-26-2	374.5	C₂₂H₃₀O₅
CFN95245	Sphenanlignan	866347-36-6	358.4	C₂₁H₂₆O₅
CFN95221	Arisanschinin E	1333378-33-8	360.5	C₂₁H₂₈O₅
CFN96694	Pregomisin	66280-26-0	390.47	C₂₂H₃₀O₆
CFN89236	Anhydrosecoisolariciresinol	29388-33-8	344.40	C₂₀H₂₄O₅
CFN96711	4,4'-Dihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan	1206464-65-4	374.43	C₂₁H₂₆O₆
CFN98363	Secoisolariciresinol	29388-59-8	362.4	C₂₀H₂₆O₆
CFN96682	Secoisolariciresinol monoglucoside	63320-67-2	524.56	C₂₆H₃₆O₁₁