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Droserone
Droserone
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Droserone
Price:
CAS No.: 478-40-0
Catalog No.: CFN91989
Molecular Formula: C11H8O4
Molecular Weight: 204.18 g/mol
Purity: >=98%
Type of Compound: Quinones
Physical Desc.: Powder
Source: The herbs of Plumbago zeylanica
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Droserone exerts an antifungal effect on a wide range of plant and human fungal pathogens. Droserone inhibits in vitro measles virus infection.
Targets: Antifection
In vitro:
Planta Med. 2017 Feb;83(3-04):232-238.
The Plant-Derived Naphthoquinone Droserone Inhibits In Vitro Measles Virus Infection.[Pubmed: 27420351 ]
The naphthoquinone Droserone (1) is a natural product occurring in dicotyledonous plants.
METHODS AND RESULTS:
We have now observed that the addition of 1 during infection of tissue culture cells with measles virus considerably reduced the infection. Interestingly, the infection was inhibited only when Droserone (1) was added during virus entry, but not when added to the cells prior to virus uptake or after virus uptake. These findings suggest that 1 interacts with viral particles to reduce infectivity. The formation of progeny measles virus particles was inhibited to 50 % by Droserone (1) at a concentration (IC50) of approximately 2 μM with a half-maximal cytotoxicity (CC50) of about 60 μM for Vero cells. Other tested naphthoquinone derivatives, among them the likewise natural plumbagin (2), but also synthetic analogs, were either more cytotoxic or not as effective as 1.
CONCLUSIONS:
Thus, our data do not support the development of naphthoquinone derivatives into antiviral compounds, but suggest that they may be interesting research tools to study measles virus entry into cells.
J Exp Bot. 2010 Mar;61(3):911-22.
Induced production of antifungal naphthoquinones in the pitchers of the carnivorous plant Nepenthes khasiana.[Pubmed: 20018905]
Nepenthes spp. are carnivorous plants that have developed insect capturing traps, evolved by specific modification of the leaf tips, and are able to utilize insect degradation products as nutritional precursors. A chitin-induced antifungal ability, based on the production and secretion to the trap liquid of Droserone and 5-O-methylDroserone, is described here.
METHODS AND RESULTS:
Such specific secretion uniquely occurred when chitin injection was used as the eliciting agent and probably reflects a certain kind of defence mechanism that has been evolved for protecting the carnivory-based provision of nutritional precursors. The pitcher liquid containing Droserone and 5-O-methylDroserone at 3:1 or 4:1 molar ratio, as well as the purified naphthoquinones, exerted an antifungal effect on a wide range of plant and human fungal pathogens. When tested against Candida and Aspergillus spp., the concentrations required for achieving inhibitory and fungicidal effects were significantly lower than those causing cytotoxicity in cells of the human embryonic kidney cell line, 293T.
CONCLUSIONS:
These naturally secreted 1,4-naphthoquinone derivatives, that are assumed to act via semiquinone enhancement of free radical production, may offer a new lead to develop alternative antifungal drugs with reduced selectable pressure for potentially evolved resistance.
Droserone Description
Source: The herbs of Plumbago zeylanica
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.8976 mL 24.4882 mL 48.9764 mL 97.9528 mL 122.441 mL
5 mM 0.9795 mL 4.8976 mL 9.7953 mL 19.5906 mL 24.4882 mL
10 mM 0.4898 mL 2.4488 mL 4.8976 mL 9.7953 mL 12.2441 mL
50 mM 0.098 mL 0.4898 mL 0.9795 mL 1.9591 mL 2.4488 mL
100 mM 0.049 mL 0.2449 mL 0.4898 mL 0.9795 mL 1.2244 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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