Science | Nature | Cell | View More
Natural Products
Emodin 1-O-beta-D-glucoside
Emodin 1-O-beta-D-glucoside
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Emodin 1-O-beta-D-glucoside
Price: $298 / 20mg
CAS No.: 38840-23-2
Catalog No.: CFN93238
Molecular Formula: C21H20O10
Molecular Weight: 432.38 g/mol
Purity: >=98%
Type of Compound: Anthraquinones
Physical Desc.: Powder
Source: The roots and rhizomes of Rheum palmatum L.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $100.6 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Medizinische Universit?t Wien (Austria)
  • Korea Institute of Oriental Med... (Korea)
  • VIB Department of Plant Systems... (Belgium)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • Universite Libre de Bruxelles (Belgium)
  • Macau University of Science and... (China)
  • Calcutta University (India)
  • Universidad de Buenos Aires (Argentina)
  • Griffith University (Australia)
  • Nanjing University of Chinese M... (China)
  • University of Wollongong (Australia)
  • More...
Package
Featured Products
Euphorbia factor L2

Catalog No: CFN92884
CAS No: 218916-51-9
Price: $40/20mg
Amygdalin

Catalog No: CFN98373
CAS No: 29883-15-6
Price: $30/20mg
1-Dehydro-10-gingerdione

Catalog No: CFN92374
CAS No: 136826-50-1
Price: $ / mg
Cyanidin-3-O-glucoside chloride

Catalog No: CFN99740
CAS No: 7084-24-4
Price: $118/20mg
Hypaconitine

Catalog No: CFN99200
CAS No: 6900-87-4
Price: $98/20mg
Ginkgolic acid C15:1

Catalog No: CFN90161
CAS No: 22910-60-7
Price: $118/20mg
trans-3-Hydroxycinnamic acid

Catalog No: CFN98181
CAS No: 14755-02-3
Price: $30/20mg
Gomisin A

Catalog No: CFN98990
CAS No: 58546-54-6
Price: $60/20mg
Lasiocarpine

Catalog No: CFN00289
CAS No: 303-34-4
Price: $ /
Ganoderenic acid A

Catalog No: CFN92236
CAS No: 100665-40-5
Price: $318/10mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Emodin 1-O-beta-D-glucoside has neuroprotective and uncoupling activities, and that it may be the a new uncoupler of nNOS-PSD-95. It shows inhibitory effects on various tumor cells proliferation.
Targets: NOS
In vitro:
J Pharm Biomed Anal. 2018 May 30;154:180-190.
A surface magnetic imprinted polymers as artificial receptors for selective and efficient capturing of new neuronal nitric oxide synthase-post synaptic density protein-95 uncouplers.[Pubmed: 29550707 ]

METHODS AND RESULTS:
In this work, surface magnetic molecularly imprinted polymers (SMMIPs) were synthesized and used as artificial receptors in the dispersive magnetic solid phase extraction (DMSPE) for capturing potential neuronal nitric oxide synthase-post synaptic density protein-95 (nNOS-PSD-95) uncouplers, which is known as neuroprotection against stroke. Factors that affected selective separation and adsorption of the artificial receptors, such as the amount of template, the types of functional monomer and porogen solvents, and the molar ratio of template/functional monomer/cross-linker were optimized. The artificial receptors were also characterized using fourier transformed infrared, scanning electron microscope, thermal gravimetric analysis and physical property measurement systems. Multiple interactions between template and SMMIPs led to larger binding capacities, faster binding kinetics, quicker separation abilities and more efficient selectivity than the surface magnetic nonimprinted polymers (SMNIPs). The SMMIPs were successfully applied to capture potential nNOS-PSD-95 uncouplers from complex samples, and eight compounds were seized and confirmed rapidly when combined with HPLC and MS. The detection of the new nNOS-PSD-95 uncouplers ranged from 0.001 to 1.500 mg/mL with correlation coefficients of 0.9990-0.9995. The LOD and LOQ were 0.10-0.68 μg/mL and 0.47-2.11 μg/mL, respectively.
CONCLUSIONS:
The neuroprotective effect and co-immunoprecipitation test in vitro revealed that Emodin 1-O-beta-D-glucoside , Rhaponticin, Gnetol and 2,3,5,4'-Tetrahydroxystilbene-2-O-β-d-glucoside have neuroprotective and uncoupling activities, and that they may be the new uncouplers of nNOS-PSD-95.
Life Sci. 1997;61(23):2335-44.
A tumor cell growth inhibitor from Polygonum hypoleucum Ohwi.[Pubmed: 9408056]
Polygonum hypoleucum Ohwi (P. hypoleucum Ohwi) has been used as a Chinese medicine for a long time.
METHODS AND RESULTS:
In the present study, four anthraquinones, emodin, Emodin 1-O-beta-D-glucoside (49A), physcion (62A), and physcion 1-O-beta-D-glucoside (50A) were identified from P. hypoleucum Ohwi and their inhibitory effects on various tumor cells proliferation were investigated. On a percentage basis, emodin had the highest suppressing activity on the various tumor cells proliferation. At 10 microg/ml, the percentage inhibition on K562 cells proliferation for emodin, 49A, 62A, and 50A were 97+/-3.4%, 18+7.3%, 24+/-3.6%, and 31+/-8.9%, respectively. However, inhibitory activities of 10 microg/ml of emodin, 49A, 62A, or 50A on Raji cells proliferation were 98+/-5.0%, 25+/-5.0%, 22+/-3.2%, and 28+/-4.3%, respectively. It was also found that the both C1 and C3 positions of emodin were important for antitumor action. The IC50s of emodin, 49A, 62A, and 50A on various tumor cells were also calculated. The IC50 of emodin on K562 cells was significantly lower than on Raji, HeLa, Calu-1, Wish, and Vero cells (1.5+/-0.2 vs. 2.8+/-0.4 microg/ml, P < 0.01 ;1.5+/-0.2 vs. 8.4+/-1.6 microg/ml; 1.5+/-0.2 vs. 8.9+/-1.0 microg/ml; 1.5+/-0.2 vs. 8.7+/-0.5 microg/ml; 1.5/-0.2 vs. 3.5+/-0.12 microg/ml; P < 0.001).
CONCLUSIONS:
The results indicated that K562 and Raji cells were more sensitive to emodin treatment. Cell viability test indicated that inhibitory effect of emodin on various tumor cell lines was not through direct cytotoxicity. It suggested P. hypoleucum Ohwi included a tumor cell growth inhibitor.
J Chem Ecol. 1992 Oct;18(10):1833-40.
Allelochemicals fromPolygonum sachalinense Fr. Schm. (Polygonaceae).[Pubmed: 24254724 ]
The root exudates fromPolygonum sachalinense in a recirculating system significantly inhibited lettuce seedling growth. The rhizomes and roots ofP. sachalinense were extracted with 80% acetone.
METHODS AND RESULTS:
Bioassay of the neutral-acidic fraction on the TLC agar plate showed the inhibitory activity corresponded to the two yellow pigment bands. Two orange needles were isolated and identified as anthraquinone compounds: emodin and physcion. Both compounds exhibited inhibitory activities against the seedling growth of several testing plant species. Glucosides were isolated fromP. sachalinense and were identified as emodin-1-O-β-D-glucoside(Emodin 1-O-beta-D-glucoside ) and physcion-1-O-β-D-glucoside, respectively. On plant growth bioassay, these glucosides showed no phytotoxic activity against lettuce seedlings. The concentrations of emodin, physcion, and their glucosides from rhizome with roots, aerial parts, fallen leaves, and soil were determined. The rhizome with roots and fallen leaves contained emodin and physcion at relatively high concentrations. Emodin also occurs in the soil of this plant community with effective concentrations in the fall.
CONCLUSIONS:
The results indicate that these anthraquinones are responsible for the observed interference and are potent allelopathic substances.
Emodin 1-O-beta-D-glucoside Description
Source: The roots and rhizomes of Rheum palmatum L.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Mahuannin G

Catalog No: CFN95553
CAS No: N/A
Price: $318/5mg
erythro-Austrobailignan-6

Catalog No: CFN95501
CAS No: 114127-24-1
Price: $318/10mg
Methyl ganoderenate F

Catalog No: CFN95573
CAS No: N/A
Price: $413/5mg
Microgrewiapine A

Catalog No: CFN95125
CAS No: 1420777-30-5
Price: $413/5mg
3'-Hydroxy-5,7,4'-trimethoxyflavon...

Catalog No: CFN95396
CAS No: 33554-52-8
Price: $318/5mg
Diosmin Impurity 5

Catalog No: CFN95311
CAS No: 122087-66-5
Price: $318/10mg
(R)-Mucronulatol

Catalog No: CFN95492
CAS No: 57128-11-7
Price: $318/10mg
11alpha-hydroxy-3,7-dioxo-5alpha-l...

Catalog No: CFN95592
CAS No: 1245703-70-1
Price: $413/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.3128 mL 11.5639 mL 23.1278 mL 46.2556 mL 57.8195 mL
5 mM 0.4626 mL 2.3128 mL 4.6256 mL 9.2511 mL 11.5639 mL
10 mM 0.2313 mL 1.1564 mL 2.3128 mL 4.6256 mL 5.782 mL
50 mM 0.0463 mL 0.2313 mL 0.4626 mL 0.9251 mL 1.1564 mL
100 mM 0.0231 mL 0.1156 mL 0.2313 mL 0.4626 mL 0.5782 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Euphorbia factor L2

Catalog No: CFN92884
CAS No: 218916-51-9
Price: $40/20mg
Amygdalin

Catalog No: CFN98373
CAS No: 29883-15-6
Price: $30/20mg
1-Dehydro-10-gingerdione

Catalog No: CFN92374
CAS No: 136826-50-1
Price: $ / mg
Cyanidin-3-O-glucoside chloride

Catalog No: CFN99740
CAS No: 7084-24-4
Price: $118/20mg
Hypaconitine

Catalog No: CFN99200
CAS No: 6900-87-4
Price: $98/20mg
Ginkgolic acid C15:1

Catalog No: CFN90161
CAS No: 22910-60-7
Price: $118/20mg
trans-3-Hydroxycinnamic acid

Catalog No: CFN98181
CAS No: 14755-02-3
Price: $30/20mg
Gomisin A

Catalog No: CFN98990
CAS No: 58546-54-6
Price: $60/20mg
Lasiocarpine

Catalog No: CFN00289
CAS No: 303-34-4
Price: $ /
Ganoderenic acid A

Catalog No: CFN92236
CAS No: 100665-40-5
Price: $318/10mg
Tags: buy Emodin 1-O-beta-D-glucoside | Emodin 1-O-beta-D-glucoside supplier | purchase Emodin 1-O-beta-D-glucoside | Emodin 1-O-beta-D-glucoside cost | Emodin 1-O-beta-D-glucoside manufacturer | order Emodin 1-O-beta-D-glucoside | Emodin 1-O-beta-D-glucoside distributor