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Epiaschantin
Epiaschantin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Epiaschantin
Price: $368 / 5mg
CAS No.: 41689-50-3
Catalog No.: CFN96901
Molecular Formula: C22H24O7
Molecular Weight: 400.42 g/mol
Purity: >=98%
Type of Compound: Lignans
Physical Desc.: Powder
Source: The trunk barks of Hernandia nymphaeifolia.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $368 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • University of Illinois at Chicago (USA)
  • Chiang Mai University (Thailand)
  • Universite de Lille1 (France)
  • Cancer Research Initatives Foun... (Malaysia)
  • University of Bonn (Germany)
  • Universidad de La Salle (Mexico)
  • Chinese University of Hong Kong (China)
  • Universitas islam negeri Jakarta (Indonesia)
  • University of Lodz (Poland)
  • Auburn University (USA)
  • University of Hawaii Cancer Center (USA)
  • More...
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: (+)-Epiaschantin shows marginal cancer cell line inhibitory activities. It also has anti-platelet aggregation activity.
In vitro:
J Nat Prod. 2004 Feb;67(2):214-20.
Antineoplastic agents. 522. Hernandia peltata (Malaysia) and Hernandia nymphaeifolia (Republic of Maldives).[Pubmed: 14987061 ]
Bioassay (P388 lymphocytic leukemia cell line and human tumor cell lines)-guided separation of the extracts prepared from the tropical and coastal trees Hernandia peltata (Malaysia) and Hernandianymphaeifolia (Republic of Maldives) led to the isolation of a new lignan designated as hernanol (1) and 12 previously known lignans: (-)-deoxypodophyllotoxin (2), deoxypicropodophyllin (3), (+)-Epiaschantin (4), (+)-epieudesmin (5), praderin (6), 5'-methoxyyatein (7), podorhizol (8), deoxypodorhizone (9), bursehernin (10), kusunokinol (11), clusin (12), and (-)-maculatin (13). The oxidative cyclization (with VOF(3)) of lignans 8, 9, and 10 resulted in a new and unusual benzopyran (14), isostegane (15), and a new dibenzocyclooctadiene lactone (16), respectively.
METHODS AND RESULTS:
The structure and relative stereochemistry of hernanol (1) and lignans 3, 7, 8, 9, 10, 11, and 12 were determined by 1D and 2DNMR and HRMS analyses. The structures and absolute stereochemistry of structures 2, 4, 5, 6, 13, 14, 15, and 16 were unequivocally determined by single-crystal X-ray diffraction analyses. Evaluation against the murine P388 lymphocytic leukemia cell line and human tumor cell lines showed podophyllotoxin derivatives 2 and 3 to be strong cancer cell line growth inhibitors and substances 4, 5, 8, and 15 to have marginal cancer cell line inhibitory activities.
CONCLUSIONS:
Seven of the lignans and one of the synthetic modifications (14) inhibited growth of the pathogenic bacterium Neisseria gonorrhoeae.
Planta Med. 1996 Dec;62(6):528-33.
New dimeric aporphine alkaloids and cytotoxic constituents of Hernandia nymphaeifolia.[Pubmed: 9000885]
Three minor new dimeric aporphine alkaloids, oviisocorydine (1), ovihernangerine (2), and oxohernandaline (3), along with four known alkaloids, (+)-hernandaline, (+)-thallcarpine, (+)-N-methylovigerine, and N-methylcorydaldine, and five known lignans, (+)-epimagnolin, (+)-Epiaschantin, (+)-epiyangambin, (-)-deoxypodophyllotoxin, and (-)-yatein, have been additionally isolated from the trunk bark of Hernandia nymphaeifolia.
METHODS AND RESULTS:
The structures of these compounds were elucidated by spectroscopic methods. Among forty-four isolates obtained till now, nine compounds, hernandonine (4), hernanymphine (5), demethylsonodione (6), (+)-ovigerine (7), (+)-N-methylovigerine (8), N-formyldehydroovigerine (9), 4-methoxyoxohernandaline (10), (-)-deoxypodophyllotoxin (11), and (-)-yatein (12) showed significant cytotoxic activities (ED50 values < 1 microgram/ml) against P-388, KB16, A549, and HT-29 cell lines.
Epiaschantin Description
Source: The trunk barks of Hernandia nymphaeifolia.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
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IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.4974 mL 12.4869 mL 24.9738 mL 49.9476 mL 62.4344 mL
5 mM 0.4995 mL 2.4974 mL 4.9948 mL 9.9895 mL 12.4869 mL
10 mM 0.2497 mL 1.2487 mL 2.4974 mL 4.9948 mL 6.2434 mL
50 mM 0.0499 mL 0.2497 mL 0.4995 mL 0.999 mL 1.2487 mL
100 mM 0.025 mL 0.1249 mL 0.2497 mL 0.4995 mL 0.6243 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Planta Med. 2000 Apr;66(3):251-6.
Anti-platelet aggregation alkaloids and lignans from Hernandia nymphaeifolia.[Pubmed: 10821052]
A new aporphine, N-(N-methylcarbamoyl)-O-methyl-bulbocapnine (1), together with seven known compounds, (-)-5'-methoxypodorhizol (2), a mixture of beta-sitosterone (3) and stigmasta-4,22-dien-3-one (4), a mixture of 3 beta-hydroxystigmast-5-en-7-one (5) and 3 beta-hydroxystigmasta-5,22-dien-7-one (6), and a mixture of 6 alpha-hydroxystigmast-4-en-3-one (7) and 6 alpha-hydroxystigmasta-4,22-dien-3-one (8), were isolated in continuing studies on the trunk bark of Formosan Hernandia nymphaeifolia.
METHODS AND RESULTS:
The structures of these compounds were determined through spectral analyses. In addition, the previously reported six alkaloids, laurotetanine, oxohernagine, thalicarpine, reticuline, (+)-vateamine-2'-beta-N-oxide, (+)-hernandaline and six lignans, (+)-Epiaschantin, (+)-epimagnolin, (+)-epiyangambin, (-)-hernone, (-)-yatein, (-)-deoxypodophyllotoxin were demonstrated to have anti-platelet aggregation activity.
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