Epitulipinolide diepoxide | CAS:39815-40-2

Epitulipinolide diepoxide

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Product Name	Epitulipinolide diepoxide
Price:
CAS No.:	39815-40-2
Catalog No.:	CFN98630
Molecular Formula:	C₁₇H₂₂O₆
Molecular Weight:	322.4 g/mol
Purity:	>=98%
Type of Compound:	Sesquiterpenoids
Physical Desc.:	Powder
Source:	The herbs of Liriodendron chinense (Hemsl.) Sarg.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
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Description:

Epitulipinolide diepoxide has antioxidative and chemopreventive activities in skin melanoma cells, can significantly inhibit the proliferation of melanoma cells, it possesses cytotoxic activity against KB cells.

In vitro:

Molecules. 2014 Apr 3;19(4):4234-45.

Antioxidant and anticancer constituents from the leaves of Liriodendron tulipifera.[Pubmed: 24705566]

METHODS AND RESULTS:
Sixteen compounds were extracted and purified from the leaves of Liriodendron tulipifera. These compounds include aporphines, oxoaporphine, coumarin, sesquiterpene lactone, benzenoids, cyclitol and steroids. (+)-Norstephalagine (2) (an aporphine) and scopoletin (8) (a coumarin) were isolated from Liriodendron tulipifera leaves from the first time. The identified compounds were screened for their antiradical scavenging, metal chelating and ferric reducing power activities. The results have showed that these compounds have antioxidative activity. The study has also examined the chemopreventive property of the isolated compounds against human melanoma cells A375. The results shown that (-)-anonaine (1), (-)-liridinine (3), (+)-lirinidine (6), lysicamine (7) and Epitulipinolide diepoxide (9) significantly inhibited the proliferation of melanoma cells.
CONCLUSIONS:
These results revealed that these compounds have antioxidative activity and chemopreventive activity in skin melanoma cells.

Epitulipinolide diepoxide Description

Source:	The herbs of Liriodendron chinense (Hemsl.) Sarg.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antioxidants Compound Library Cytotoxic Compound Library Anti-proliferation Compound Library Cancer chemoprevention Compound Library Sesquiterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.1017 mL	15.5087 mL	31.0174 mL	62.0347 mL	77.5434 mL
5 mM	0.6203 mL	3.1017 mL	6.2035 mL	12.4069 mL	15.5087 mL
10 mM	0.3102 mL	1.5509 mL	3.1017 mL	6.2035 mL	7.7543 mL
50 mM	0.062 mL	0.3102 mL	0.6203 mL	1.2407 mL	1.5509 mL
100 mM	0.031 mL	0.1551 mL	0.3102 mL	0.6203 mL	0.7754 mL

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