Ergocristine | CAS:511-08-0 | Manufacturer ChemFaces

Ergocristine

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Description:

Ergocristine, a dopamine agonist, can block prolactin release without any noticeable latent period.

Targets:

Dopamine

In vivo:

Canadian Journal of Physiology & Pharmacology, 1979, 57(11):1313-1316.

Effect of ergocristine on prolactin secretion in the male rat with pituitaries grafted beneath the kidney capsule.[Reference: WebLink]

METHODS AND RESULTS:
Male rats in which three pituitaries were grafted beneath the kidney capsule showed approximately a fourfold increase in circulating plasma prolactin concentration. The elevated plasma prolactin concentration did not remain at a constant level but fluctuated with time. The elevated prolactin concentration declined immediately after a single bolus injection of Ergocristine (30 micrograms/kg). The slope of the prolactin decay curve, determined by sequential blood sampling, was parallel to a theoretical slope having a 7-min half-life.
CONCLUSIONS:
This result indicates that Ergocristine blocked prolactin secretion immediately and completely as the decay curve (T 1/2 = 6.5 min, confidence interval 4.5--11.3) resulting from the administration of Ergocristine is the same as the endogenous prolactin decay curve (T 1/2 = 7 min).

Ergocristine Description

Source:	The extract of tall fescue (Lolium arundinaceum) seed infected by
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Animal Research:

Cell and Tissue Research, 1983, 232(2):249-256.

Extensive ultrastructural changes in rat mammotrophs following administration of the dopamine agonist ergocriptine-reflecting inhibition of prolactin release.[Reference: WebLink]

We have demonstrated an extensive reorganization of organ elles in mammotrophs immediately following administration of Ergocristine (a dopamine agonist) to estradiol-primed male rats.
METHODS AND RESULTS:
Our ultrastructural findings are consistent with our previous results that Ergocristine can block prolactin release without any noticeable latent period. Following three-week priming of male rats with estradiol implants, Ergocristine was administered by a bolus injection through an indwelling cannula. Within two min of its administration, Ergocristine induced dramatic changes in the ultrastructure of mammotrophs, i.e., (1) increased numbers of secretory granules, (2) peripheral relocation of rough endoplasmic reticulum which tends to sequester secretory granules, (3) change in location of nucleus and (4) increased numbers of intracellular bodies associated with secretory granules.
CONCLUSIONS:
We suggest that the extensive ultrastructural changes that occurred in such a short period following Ergocristine administration may be indications of specific factors associated with blockage of hormone release.

Product Name	Ergocristine
Price:
CAS No.:	511-08-0
Catalog No.:	CFN70387
Molecular Formula:	C₃₅H₃₉N₅O₅
Molecular Weight:	609.7 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The extract of tall fescue (Lolium arundinaceum) seed infected by
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.6402 mL	8.2008 mL	16.4015 mL	32.803 mL	41.0038 mL
5 mM	0.328 mL	1.6402 mL	3.2803 mL	6.5606 mL	8.2008 mL
10 mM	0.164 mL	0.8201 mL	1.6402 mL	3.2803 mL	4.1004 mL
50 mM	0.0328 mL	0.164 mL	0.328 mL	0.6561 mL	0.8201 mL
100 mM	0.0164 mL	0.082 mL	0.164 mL	0.328 mL	0.41 mL

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